|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 3 | Distinctions between bipolar and unipolar depression 显示文摘 | Cuellar AK Johnson SL Winters R | 2005 | Clin Psychol Rev2005，25，3： | 1 |
| 4 | Close range radar remote sensing of concrete degradation in a textile factory floor 显示文摘 | Cuellar V Hernández M C | 2001 | J Appl Geophys2001，47，34： | 1 |
| 5 | Asymmetric reduction of aromatic ketones显示文摘 | Morales H R Perez-Juarez M Cuellar L | 1984 | Synth Commun1984，14，13： | 1 |
| 6 | Obstructive sleep apnea as an independent stroke risk factor:a review of the evidence,stroke prevention guidelines,and implications for neuroscience nursing practice显示文摘 | King S Cuellar N | 2016 | J Neurosci Nurs2016，48，3： | 1 |
| 7 | Long-Term Outcome of Aortic Dissection With Patent False Lumen: Predictive Role of Entry Tear Size and Location显示文摘 | Artur Evangelista Armando Salas Aida Ribera Ignacio Ferreira-González Hug Cuellar Victor Pineda Teresa González-Alujas Bart Bijnens Gaietà Permanyer-Miralda David Garcia-Dorado | 2012 | Circulation2012，，25： | 1 |
| 8 | Spinal c-fos expres- sion associated with spontaneous bitting in a mouse model of dry slin pruritus显示文摘 | Nojima H Cuellar JM Simons CT | 2004 | Neurosci Lett2004，361，： | 1 |
| 9 | 显示文摘 | Fischer BM Cuellar JG Diehl ML | 2003 | Am J Respir Cell Mol Physiol2003，284，4： | 1 |
| 10 | Focal- nodularhyperplasiaandhepaticadenoma: areview 显示文摘 | Lizardi- cerveraj Cuellar - gamboal Motola- kubad | 2006 | AnnHe-pato2006，3，3： | 1 |
| 11 | 15-YEAR EXPERIENCE WITH THE MANAGEMENT OF EXTRINSIC URETERAL OBSTRUCTION WITH INDWELLING URETERAL STENTS显示文摘 | STEVE Y. CHUNG ROBERT J. STEIN DOUGLAS LANDSITTEL BENJAMIN J. DAVIES DAVID C. CUELLAR RONALD L. HREBINKO TATUM TARIN TIMOTHY D. AVERCH | 2004 | The Journal of Urology2004，，2： | 1 |
| 12 | Management of spondyloarthropa thies显示文摘 | Cuellar ML Espinoza LR | 1996 | Curr Opin Rheumatol1996，8，4： | 1 |
| 13 | Head and spinal cord injury: diagnosis and management 显示文摘 | CHITTIBOINA P CUELLAR SAENZ H NOTARIANNI C | 2012 | Neurol Clin2012，30，1： | 1 |
| 14 | Field experiment performance of the receiver elements for a fourier telescopy ima- ging system显示文摘 | MATHIS J STAPP J CUELLAR E L | 2005 | SPIE2005，5896，58： | 1 |
| 15 | Spondylolysis and spina bifida occulta in pediatric patients: prevalence study using computed tomography as a screening method显示文摘 | Urrutia J Cuellar J Zamora T | 2014 | Eur Spine J2014，22，8： | 1 |
| 16 | Targeting the mammalian target of rapamycin pathway with everolimus:implications for the management of metastatic breast cancer显示文摘 | Ng VC Johnson JJ Cuellar S | 2015 | J Oncol Pharm Pract2015，21，6： | 1 |
| 17 | Laboratory and field experimental demonstration of a fourier teleseopy imaging system 显示文摘 | CUELLAR E L STAPP J COOPER J | 2005 | SPIE2005，5896，58： | 1 |
| 18 | Holmium laser percutaneous nephrolithotomy using a unique suction device显示文摘 | Cuellar DC Averch TD | 2004 | J Endourol2004，18，8： | 1 |
| 19 | Conditional loss of dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus显示文摘 | Davis TH Cuellar TL Koch SM | | 0，，17： | 1 |
| 20 | Sweetpotato viruses: 15 years of progress on understanding and managing complex diseases显示文摘 | Clark C A Davis J A Abad J A Cuellar W J Fuentes S Kreuze J F Gibson R W Mukasa S Tugume A K Tairo F Valkonen J P T | 2012 | Plant Disease2012，96，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员