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| 1 | Implications of multigene testing for hereditary breast cancer in primary care显示文摘Approximately 1 in 8 women will develop breast cancer during their lifetime and the risk factors include age, family history, and reproductive factors. In women with a family history of breast cancer, there is a proportion in which a gene mutation can be the cause of the predisposition for breast cancer. A careful assessment of family and clinical history should be performed in these women in order to determine if a genetic counseling referral is indicated. In cases of hereditary breast cancer, genetic testing with a multigene panel can identify specific genetic mutations in over 100 genes. The most common genes mutated in hereditary breast cancer are the high-penetrance BRCA1 and BRCA2 genes. In addition, other mutations in high-penetrance genes in familial cancer syndromes and mutations in DNA repair genes can cause hereditary breast cancer. Mutations in low-penetrance genes and variants of uncertain significance may play a role in breast cancer development, but the magnitude and scope of risk in these cases remain unclear, thus the clinical utility of testing for these mutations is uncertain. In women with high-penetrance genetic mutations or lifetime risk of breast cancer > 20%, risk-reducing interventions, such as intensive screening, surgery, and chemoprevention, can decrease the incidence and mortality of breast cancer. | Meghna S Trivedi Katherine D Crew | 2016 | World Journal of Obstetrics and Gynecology2016，5，1： | 2 |
| 2 | Endocrine disruptors: present issues, future directions显示文摘 | Crews D Willingham E Skipper J K | 2000 | Q Rev Biol2000，75，3： | 2 |
| 3 | Neurogenesis in adolescent brain is potently inhibited by ethanol显示文摘 | Crews FT Mdzinarishvili A Kim D | 2006 | Neuroscience2006，137，： | 1 |
| 4 | A eyclooxygenase-2 (COX- 2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectai carcino- ma cells expressing COX-2 protein: regulation of COX-2 by butyrate显示文摘 | Crew T E Elder D J Paraskeva C | 2000 | Carcinogenesis2000，21，： | 1 |
| 5 | 3-monochloropropane-1,2-diol (3-MCPD) in soy sauces and similar products available from retail outlets in the UK 显示文摘 | Macarthur R Crews C Davies A Brereton P Hough P Harvey D | 2000 | Food Additives and Contaminants2000，17，11： | 1 |
| 6 | Estradiol and incubation temper-ature modulate regulation of steroidogenic factor1in the developing gonad of the red-eared slider turtle显示文摘 | Fleming A Crews D | 2001 | Endocrinology2001，142，4： | 1 |
| 7 | Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts 显示文摘 | Hawkins MB Thornton JW Crews D | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 8 | Correlations betweencommonly used objective signs and symptoms for the diagnosis of dryeye disease: clinical implications 显示文摘 | Sullivan B D Crews L A Messmer E M | 2014 | Acta ophthalmologica2014，92，2： | 1 |
| 9 | Benzene accumulation in horticultural crops显示文摘 | COLLINS C D BELL J N B CREWS C | 2000 | Chemosphere2000，40，1： | 1 |
| 10 | Identifi- cation of a third distinct estrogen receptor and reclassi- fication of estrogen receptors in teleosts 显示文摘 | Hawkins M B Thornton J W Crews D | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 11 | Dietary energy restriction in mice reduces hepatic expression of glucose- regulated protein 78 (Bip) and 94 mRNA 显示文摘 | Spindler S R Crew M D Mote P L Grizzle J M Wolford R L | 1990 | J Nutr1990，120，11： | 1 |
| 12 | Sex-determining potencies vary among female incubation temperature in a turtle显示文摘 | Bull J.J Wibbels T Crews D | | 0，，： | 1 |
| 13 | Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling显示文摘 | THORNTON J W NEED E CREWS D | 2003 | Science2003，301，5640： | 1 |
| 14 | Multi-objective control optimization for semi-active vehicle suspension 显示文摘 | CREWS J H MATTSON M G~ BUCKNER G D | 2011 | J Sound Vib2011，330，： | 1 |
| 15 | Measurement of magnetic viscosity in NdFeB显示文摘 | Crew D C Mcconmick P G Street R | 1996 | IEEE Transactions on Magnetics1996，32，5： | 1 |
| 16 | An automated method for the analysis of T-cell receptor repertoires:rapid RT-PCR fragment length analysis of the T-cell receptor β chain complementarity-determining region 3显示文摘 | Lue C Mitani Y Crew M D | 1999 | Am J Chin Pathol1999，111，： | 1 |
| 17 | Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts显示文摘 | Hawkins B Thomton J W Crews D | 2000 | PNAS2000，97，10： | 1 |
| 18 | 1H NMR-based metabolomic analysis of liver,serum,and brain following ethanol administration in rats显示文摘 | NICHOLAS P C KIM D CREWS F T | | 0，，： | 1 |
| 19 | An eleetroencephalographic meas ures of attentional patterns prior to the golf putt 显示文摘 | CREW D J LANDERS D M | 1993 | Med Sci Sports Exe1993，，11： | 1 |
| 20 | Feasibility and effectiveness of circuit training in acute stroke rehabilitation显示文摘 | Rose D Parls T Crews E | 2011 | Neurorchabil Neural Repair2011，25，2： | 1 |
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