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| 1 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 2 | Classification of semigroups of linear fractional maps in the unit ball 显示文摘 | BRACCI F CONTRERAS M DiAZ-MADRIGAL S | 2007 | AdvMath2007，，208： | 1 |
| 3 | High sensi- tivity Hall sensors with low thermal drift using AlGaAs /In- GaAs/GaAs heterostructures显示文摘 | Contreras S Aboulhouda S | 1994 | Sensors and Actuators A1994，43，： | 1 |
| 4 | Red cell alloantibody development associated with heart and lung transplantation显示文摘 | Cummins D Contreras M Amin S | | 0，，10： | 1 |
| 5 | Celecoxib and heterotopic bone formation after total hip arthroplasty 显示文摘 | Lavernia C J Contreras J S Villa J M | 2014 | J Arthroplasty2014，29，2： | 1 |
| 6 | UV-and UV/ Fe(Ⅲ)-enhanced ozonation of nitrobenzene in aqueous solution 显示文摘 | Contreras S Rodriguez M Chamarro E | 2001 | Journal of Photochemistry and Photobiology A: Chemistry2001，142，1： | 1 |
| 7 | Contribution of the ozonation pre-treatment to the biodegTadation of aqueous solutions of 2,4-dichlorophenol 显示文摘 | Contreras S Rodrtguez M Momani A F | 2003 | Water Research2003，37，13： | 1 |
| 8 | Chronic caregiver stress and IgE expression,allergen-induced proliferation,and cytokine profiles in a birth cohort predisposed to atopy显示文摘 | Wright RJ Finn P Contreras JP Cohen S Wright RO Staudenmayer J | | 0，，： | 1 |
| 9 | Developmem and validation of a method for the simultaneous extraction and separate measurement of oxytetracycline, florfenicol, oxolinic acid and flumequine from marine sediments 显示文摘 | NORAMBUENA L GRAS N CONTRERAS S | 2013 | Marine Pollu- tion Bulletin2013，73，1： | 1 |
| 10 | Comparison of different advanced oxidation processes for phenol degradation显示文摘 | Esplugas S Gimenez J Contreras S | 2002 | Water Research2002，36，： | 1 |
| 11 | Anti-angiogenic drugs as an adjunctive therapy in the surgical treatment of diabetic retinopathy显示文摘 | Figueroa M S Contreras I Noval S | 2009 | Curt Diabetes Rev2009，5，1： | 1 |
| 12 | HDT mixtures treatment strategies by gas chromatography显示文摘 | Laquerbe C Contreras S Demoment J | 2008 | Fusion Science and Technology2008，，： | 1 |
| 13 | Optic disc evaluation by Optical Coherence Tomography in nonarteritic anterior ischemic optic neuropathy显示文摘 | Contreras I Rebolleda G Noval S | 2007 | Invest Ophthalmol Vis Sci2007，48，9： | 1 |
| 14 | Mastitis in small ruminants显示文摘 | Contreras A Sierra D S' anchez A | | 0，，68： | 1 |
| 15 | Correlation analysis technique revealing ionospheric precursors of earthquakes 显示文摘 | Pulinets S A Gaivoronska T B Leyva Contreras A | 2004 | Natural Hazards and Earth System Sciences2004，4，： | 1 |
| 16 | Nutritional dep-rivation of alpha-linolenic acid decreases but does not abolishturnover and availability of unacylated docosahexaenoic acid anddocosahexaenoyl-CoA in rat brain 显示文摘 | Contreras M A Greiner R S Chang M C | 2000 | J Neurochem2000，75，6： | 1 |
| 17 | Comparision of different advanced oxidation processes for phenol degration显示文摘 | Gimenez J Contreras S etc | 2002 | Water Research2002，36，： | 1 |
| 18 | Influence of H2O2 and Fe(Ⅲ) in the photodegradation of nitrobenzene显示文摘 | Rodriguez M Kirchner A Contreras S | 2000 | Journal of Photochemistry and Photobiology A:Chemistry2000，133，1： | 1 |
| 19 | Mastitis in small ruminants显示文摘 | Contreras A Sierra D S′anchez A | 2007 | Small Ruminant Reserch2007，，68： | 1 |
| 20 | Platinum coated copper nanowires and platinum nanotubes as oxygen reduction electrocatalysts 显示文摘 | ALIA S M JENSEN K CONTRERAS C | 2013 | ACS Catalysis2013，3，3： | 1 |
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