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| 1 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 2 | Phenylmercury degradation by heterogeneous photocatalysis assisted by UV-A light显示文摘 | Miranda C Yanez J Contreras D | 2013 | Journal of Environmental Science and Health Part A2013，48，13： | 1 |
| 3 | Sorption of 2,4-dichlorophenol on modified hydrotalcites 显示文摘 | Klumpp E Contreras 0 C Klahre P | 2003 | Colloids and SurfacesA : Physicochemical Engineering Aspects2003，230，123： | 1 |
| 4 | Factors associated with poor outcomes in patients with lupus nephritis显示文摘 | Pardo V Cely C | 2005 | Lupus2005，14，： | 1 |
| 5 | A GARCH forecasting model to predict day-ahead electricity prices显示文摘 | CARCIA R C CONTRERAS J AKKEREN M | 2005 | IEEE Trans on Power Systems2005，20，2： | 1 |
| 6 | The linear e-model and {inite temperature effects显示文摘 | Contreras C Loewe M | 1990 | Int J Mod Phys A1990，，： | 1 |
| 7 | Endothelial dysfunction, obesi- ty and insulin resistance 显示文摘 | Pfieto D Contreras C SOnchez A | 2014 | Curt Vasc Pharmacol2014，12，3： | 1 |
| 8 | Wettability and spreading kinetics of AI and Mg on TiC显示文摘 | Contreras A Leon C A Drew R A L | 2003 | Scripta Materialia2003，48，： | 1 |
| 9 | Celecoxib and heterotopic bone formation after total hip arthroplasty 显示文摘 | Lavernia C J Contreras J S Villa J M | 2014 | J Arthroplasty2014，29，2： | 1 |
| 10 | Intelligent multi-Agent support for the contingency management system 显示文摘 | SHEREMETOV L B CONTRERAS M VALENCIA C | 2004 | Expert Systems with Applications2004，26，1： | 1 |
| 11 | Factors associated with poor outcomes in patients with lupus nephritis显示文摘 | Pardo V Cely C | 2005 | Lupus2005，14，11： | 1 |
| 12 | Combination of an enzymatic method and HPLC for the quantitation of cholesterol in cultured cells显示文摘 | Contreras JA Castro M Bocos C | 1992 | J Lipid Res1992，33，： | 1 |
| 13 | Cultivating in vitro coconut palms(Cocos nucifera L)under glasshouse conditions with natural light,improves in vitro photosynthesis nursery survival and growth显示文摘 | TALAVERA C CONTRERAS F ESPADAS F | 2001 | Plant Cell Tissue and Organ Culture2001，83，： | 1 |
| 14 | New insights into the epidemiology of enteropathogenic Eseherichia eoli infection 显示文摘 | Ochoa TJ Barletta F Contreras C | 2008 | Trans R Soc Trop Med Hyg2008，102，9： | 1 |
| 15 | HDT mixtures treatment strategies by gas chromatography显示文摘 | Laquerbe C Contreras S Demoment J | 2008 | Fusion Science and Technology2008，，： | 1 |
| 16 | Pigment epithelium de- rived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis显示文摘 | Ek E T Dass C R Contreras K G | 2007 | Cancer Gene Ther2007，14，7： | 1 |
| 17 | Influence of osmotic pretreatment and microwave application on properties of air dried strawberry related to structural changes显示文摘 | Contreras C Mart'n-Esparza M E | 2007 | Eur Food Res Technol2007，，224： | 1 |
| 18 | Endothelial dysfunction,obesity and insulin resistance显示文摘 | Prieto D Contreras C Sa nchez A | 2014 | Curr Vasc Pharmacol2014，12，3： | 1 |
| 19 | A general model of rift basin evolution : constraints of first order stratigraphic observations 显示文摘 | Contreras J Scholz C H King G C P | 1997 | Journal of Geophysical Research1997，102，： | 1 |
| 20 | Caspase-8 and Caspase 3 small interfering RNA decreases ischemia / reperfusion injury to the liver in mice 显示文摘 | Contreras JL Vilatoba M Eckstein C | 2004 | Surgery2004，136，2： | 1 |
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