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| 1 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 2 | Discovery from combinatorial heterogeneous catalysis:A new class of catalyst for ethane oxidative dehydrogenation at low temperatures显示文摘 | LIU Y M CONG P J ROBERT D D | 2003 | Appl Catal A2003，254，： | 1 |
| 3 | Estimation of thermal contact resistance using ultrasonic waves显示文摘 | CONG P Z ZHANG X FUJII M | 2006 | International Journal of Thermophysics2006，27，1： | 1 |
| 4 | Total energy calculation of perovskite,BaTi03,by self-consistent tight binding method显示文摘 | Cong B T Huy P N Schelling P K | | Bull Mater0，，： | 1 |
| 5 | Degrada-tion of the multiple branched alkane 2,6,10,14-tetram-ethyl-pentadecane(pristane)in Rhodococcus ruber and My-cobacterium neoaurum显示文摘 | Nhi Cong L T Mikolasch A Klenk H P | 2009 | International Biodeterioration&Biodegradation2009，63，： | 1 |
| 6 | Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno-associated viruses carry- ing siRNAs in hepatic stellate cells 显示文摘 | Cong M Liu T Wang P | 2009 | Int J Mol Med2009，24，5： | 1 |
| 7 | Tribological behaviors of 52100 steel in carbon dioxide atmosphere显示文摘 | Wu X Cong P Nanao H | 2004 | Tribology Lett2004，17，4： | 1 |
| 8 | Experimental investigation of related properties of asphalt binders containing various flame retardants 显示文摘 | Wu S Cong P Yu J | 2006 | Fuel2006，85，9： | 1 |
| 9 | Mat Sci Eng A显示文摘 | Qin Q D Zhao Y G Cong P J | 2006 | 418:1932006，418，： | 1 |
| 10 | Activated mTOR/P70S6K signaling pathway is involved in insulinoma tumorigenesis显示文摘 | Zhan H X Cong L Zhao Y P | 2012 | J Surg Oncol2012，106，8： | 1 |
| 11 | PlantLoc: an accurate web server forpredicting plant protein subcellular localization by substantialitymotif显示文摘 | Tang S Li T Cong P | 2013 | Nucleic Acids Res2013，41，： | 1 |
| 12 | Wet-Spinning Assembly of Continuous, Neat, and Macroscopic Graphene Fibers显示文摘 | Cong H P Ren X C Wang P | 2012 | Sci Rep2012，2，： | 1 |
| 13 | Crysta structures and textures of hot forged Ni48Mn30Ga22 alloy inves tigated by neutron diffraction technique 显示文摘 | CONG D Y WANG Y D ZETTERSTROM P | 2005 | Materials Sci ence and Technology2005，21，12： | 1 |
| 14 | Gradient distribution of persistent organic contaminants along northern slope of central-Himalayas, China显示文摘 | Wang X P Yao T D Cong Z Y | 2006 | Sci Total Environ2006，372，： | 1 |
| 15 | Suppression of tissue inhibitor of metal- loproteinase - 1 by recombinant adeno - associated viruses carrying siR- NAs in hepatic stellate cells显示文摘 | Cong M Liu T Wang P | 2009 | Int J Mol Med2009，24，5： | 1 |
| 16 | Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation显示文摘 | Jin Cong Shelburne Christopher P Li Guojie Potts Erin N Riebe Kristina J Sempowski Gregory D Foster W Michael Abraham Soman N | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 17 | Effects of end groups on the tribochemieal reactions of lubricants at head-disk interface 显示文摘 | MORI S CONG P NANAO H | 2004 | Tribol Lett2004，17，： | 1 |
| 18 | Flexiblegrapheuepolyaniline composite paper for high- performance supercapacitor 显示文摘 | CONG H P REN X C WANG P | 2013 | Energy Environ Sci2013，6，： | 1 |
| 19 | Determination of the enantiomers of tamsulosin hydrochloride and its synthetic intermediates by chiral liquid chromatography 显示文摘 | QI M L WANG P CONG R H | 2004 | J Chromatogr2004，59，12： | 1 |
| 20 | Reduction electrocatalyzer technique of electrodes solids dioxides (Ⅰ)显示文摘 | Cong H N Chartier P Brenet J | 1977 | J Appl Electrochem1977，7，5： | 1 |
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