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| 1 | Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma显示文摘AIM: To assess serum cartilage oligomeric matrix protein(COMP) as a marker of cirrhosis and risk of progression to hepatocellular carcinoma(HCC). METHODS: A COMP enzyme-linked immunosorbentassay was used to test 187 patients with chronic liver diseases at the time point of first evaluation. The selected patients included 72 with chronic hepatitis B infection, 75 with chronic hepatitis C infection, 22 with primary biliary cirrhosis, 7 with autoimmune hepatitis type 1, and 11 with alcoholic liver disease. Demographic, biochemical, histological and clinical characteristics of the patients were recorded at the first evaluation. One hundred and forty-seven patients were followed for a median [interquartile range(IQR)] duration of 96.5(102) mo. The clinical, biochemical and histological data, as well as the development of cirrhosis, HCC according to internationally accepted criteria and in case of death, a liver-related cause during the follow-up period, were recorded at the electronic database of our clinic. COMP determination was also performed in 43 healthy individuals who served as the control study group.RESULTS: COMP positivity(> 15 U/L) was detected in 22%-36% among chronic liver disease groups. Strikingly, almost 83% of COMP-positive patients were cirrhotic at baseline, independently of cause of liver disease. Among the patients who developed HCC during follow-up, 73.7%(14/19) were COMP positive at baseline. COMP positivity was significantly associated with older age(P < 0.001), advanced fibrosis(P = 0.001) and necroinflammatory activity(P = 0.001), higher aspartate aminotransferase(P < 0.001), alanine aminotransferase(P < 0.02), γ-glutamyl transpeptidase(P = 0.003), alkaline phosphatase(P = 0.001), bilirubin(P < 0.05), international normalized ratio(P = 0.002) and alpha-fetoprotein levels(P < 0.02), and lower albumin(P < 0.001), and platelet count(P = 0.008). COMP levels [median(IQR)] were significantly higher in cirrhotics compared to non-cirrhotics [13.8(7.9) U/L vs 9.8(4.6) U/L, respectively; P < 0.001]. On multivariate logistic regression analysis, COMP-positivity was independently associated only with cirrhosis(OR = 4.40, 95%CI: 1.33-14.69, P = 0.015). Kaplan-Meier analysis showed that COMP positivity was significantly associated with HCC development(P = 0.007) and higher incidence of liver-related death(P < 0.001). CONCLUSION: Elevated COMP levels are strongly associated with cirrhosis and HCC progression. Serum COMP is a new promising non-invasive biomarker for HCC risk assessment in surveillance programs. | Gary L Norman Nikolaos K Gatselis Zakera Shums Christos Liaskos Dimitrios P Bogdanos George K Koukoulis George N Dalekos | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 2 | Consumption of fruits and vegetables in relation to the risk of developing acute coronary syndromes;the CARDIO2000 case-control study显示文摘 | Demosthenes BP Christos P Peter K | 2003 | Nutr J2003，10，8： | 1 |
| 3 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 4 | A microeconomic view of data mining显示文摘 | Jon K Christos P Prabhakar R | 1998 | Data Mining and Knowledge Discovery1998，2，4： | 1 |
| 5 | Heart failure in beta thalassemia: a 5-year follow-up study显示文摘 | Dimitrios Th Kremastinos George A Tsetsos Dimitrios P Tsiapras George K Karavolias Vassilios A Ladis Christos A Kattamis | 2001 | The American Journal of Medicine2001，，5： | 1 |
| 6 | Restoring capability of bilinear hysteretic seismic isolation systems 显示文摘 | CHRISTOS P K TELEMACHOS B P BASIL K | 2008 | Earthquake Engineering and Structural Dynamics2008，37，6： | 1 |
| 7 | Global roaming in next-generation networks显示文摘 | Zahariadis T B Vaxevankis K G Christos P | 2002 | IEEE Communications Magazine2002，40，2： | 1 |
| 8 | Divergence of opinion and equity returns显示文摘 | Doukas J.A Chansong(Francis) K Christos P | | 0，，03： | 1 |
| 9 | Validating the clinical assessment of eustachian tube dysfunction:The Eustachian Tube Dysfunction Questionnaire(ETDQ-7)显示文摘 | MCCOUL E D ANAND V K CHRISTOS P J | 2012 | Laryngoscope2012，122，： | 1 |
| 10 | Lipase ac- tivity in Thermus thermophilusHBS:purification and characterization of the extracellular enzyme显示文摘 | Eirini K Christos P P Rigini M P | 2012 | Bio- technology and Bioprocess Engineering2012，17，3： | 1 |
| 11 | Validating the clinical assessment of eustachian tube dysfunction:The Eustachian Tube Dysfunction Questionnaire(ETDQ-7)显示文摘 | MCCOUL E D ANAND V K CHRISTOS P J | 2012 | Laryngoscope2012，122，： | 1 |
| 12 | Monitoring sleepiness with on-board electrophysiological recordings for preventing sleep deprived traffic acci dents 显示文摘 | Christos P Chen Zhe Chrysoula K P | 2007 | Clinical Neuropysiology2007，118，9： | 1 |
| 13 | A method for 3D reconstruction of coronary arteries using biplane angiography and intravaseular ultrasound images显示文摘 | CHRISTOS V B IRAKLIS C K MARINA E P | 2005 | Computerized Medical Imaging and Graphics2005，29，8： | 1 |
| 14 | Renal cell carcinoma presented with a rare case of icteric Stauffer syndrome:A case report显示文摘BACKGROUND Paraneoplastic syndromes remain poorly understood and manifest as multifaceted clinical symptoms,making their diagnosis difficult.Cholestasis can be observed in various malignancies.In rare cases,it can be a paraneoplastic manifestation,most often associated with renal cell carcinoma and other urogenital tumors,as well as with bronchial carcinoma.The classical form of Stauffer syndrome presents with a reversible anicteric increase of cholestatic liver function tests,thrombocytosis,coagulation impairment,and hepatosplenomegaly,without any proven hepatobiliary obstruction or metastases.CASE SUMMARY We report a patient who presented with elevated liver enzymes,cholestatic jaundice,weight loss and pruritus,in whom renal cell carcinoma was incidentally found during hospitalization.Clinical,laboratory,and imaging tests excluded primary hepatic cause or metastatic disease.Jaundice and laboratory abnormalities reversed completely a few months after nephrectomy.This case is an example of the many sides of renal cell carcinoma,and it focuses the clinicians’attention on the differential diagnosis of cholestasis,including Stauffer syndrome and its variant.Thus,the correct diagnosis can be straightforward and the associated malignancy can be treated promptly.All cases should be followed up with a multidisciplinary team.Interleukin(IL)-6 is proposed to contribute to the pathophysiology of the condition.The probable mechanism is proinflammatory activity by the IL-6 cytokine,causing elevation of C-reactive protein and haptoglobin and inhibition of hepatobiliary transporter gene expression,impairing biliary outflow.CONCLUSION Despite being rare,Stauffer syndrome is a potentially reversible paraneoplastic condition,when the primary cause is treatable.This syndrome should be considered by clinicians because of the remediable liver disturbance,after successful treatment of the underlying malignancy. | Dimitar R Popov Krasimir A Antonov Evelina G Atanasova Christo P Pentchev Lyuben M Milatchkov Maria D Petkova Krasimir G Neykov Rosen K Nikolov | 2022 | World Journal of Clinical Cases2022，10，25： | 0 |
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