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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | 皮肤穿支血管的解剖学研究显示文摘目的:对全身皮肤血管区域进行定性和定量分析,确定全身皮肤穿支血管的位置、数量、口径、穿支蒂的长度、类型、来源血管以及穿支所供应皮肤的面积,为穿支皮瓣提供血管解剖基础。方法:选用10具新鲜尸体,采用改良氧化铅-明胶灌注技术进行动脉灌注。将每个口径大于0.5mm的穿支血管进行解剖并记录。拍摄X线片以显示皮肤内血管的形态和分布。定量数据分析包括全身各部位的穿支血管的数量、口径、类型及其供应区域的面积。结果:发现全身128支起源血管发出440支穿支供应皮肤。其中肌皮穿支与肌间隔穿支之比为3:2。穿支平均直径为0.7mm。穿支血管的分布规律如下:①躯干皮肤的血供主要来自肌皮穿支,这些穿支在皮肤内的走行距离和分布范围大于肢体皮肤的穿支。②肢体皮肤的血供主要来自肌间隙穿支血管,主要分布在深筋膜表面,皮神经和浅静脉周围穿支之间形成链式血管吻合。③单位面积的穿支数量与皮肤的移动程度成反比,穿支的口径大小和穿支在皮肤内走行距离与皮肤移动度成正比,与穿支的供应面积成正比。结论:本研究提供详细的皮肤穿支血管解剖数据,为临床设计应用穿支皮瓣提供解剖学依据。 | 杨大平 唐茂林 Christopher R.Geddes Steve F.Morris | 2006 | 中国临床解剖学杂志2006，24，3： | 89 |
| 3 | 明胶-氧化铅血管造影术的优化显示文摘目的:在总结分析传统的血管解剖学研究技术基础上对全身性血管造影术进行重点探讨。方法:应用不同强度的明胶、不同的明胶-氧化铅配方及其多种不同组合方式的X线参数反复进行测试。结果:经测试,本实验得出明胶与氧化铅的最佳配方为:300Bloom的明胶5g,40℃温水100ml,氧化铅100g。灌注量为20~30ml/kg。结论:改良后的氧化铅—明胶灌注技术可提供高质量的血管显影效果,不失为研究皮动脉及设计穿支皮瓣的最好方法之一,而其他方法也能为血管解剖学提供补充信息。 | 楼新法 梅劲 Christopher R.Geddes 唐茂林 | 2006 | 中国临床解剖学杂志2006，24，3： | 133 |
| 4 | 成人自发性脑出血处理指南——2007年更新版:美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南:美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S. Ogilvy Paul Vespa Mario Zuccarello 王玉洁(译) 刘娟(译) 白璇(译) 李新辉 孙虹(译) 姚志成(译) 张慧(译) 牛英翔(译) | 2007 | 国际脑血管病杂志2007，15，7： | 234 |
| 5 | 未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。 | B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 | 2015 | 国际脑血管病杂志2015，23，8： | 127 |
| 6 | 儿童功能性胃肠病罗马Ⅳ标准显示文摘罗马标准是目前关于功能性胃肠病( FGID)分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年,根据年龄不同,婴幼儿(0-36个月)和儿童(〉36个月) FGID的罗马Ⅲ诊断标准发布,但相关的流行病学、病理生理学、诊断检查、治疗策略以及预后等资料都很少。 | Marc A. Benninga Samuel Nurko Christophe Faure Paul E. Hyman Ian St. James Roberts Neil L. Schechter Jeffrey S. Hyams Carlo Di Lorenzo Miguel Saps Robert J. Shulman Annamaria Staiano Miranda van Tilburg | 2017 | 中华儿科杂志2017，55，1： | 108 |
| 7 | Severe acute pancreatitis: pathogenesis, diagnosis and surgical management显示文摘BACKGROUND: Severe acute pancreatitis is a subtype of acute pancreatitis, associated with multiple organ failure and systemic inflammatory response syndrome. In this qualitative review we looked at the principles of pathogenesis, classification and surgical management of severe acute pancreatitis. We also looked at the current shift in paradigm in the management of severe acute pancreatitis since the guideline developed by the British Society of Gastroenterology.DATA SOURCES: Studies published between 1st January 1991 and 31st December 2015 were identified with Pub Med, MEDLINE, EMBASE and Google Scholar online search engines using the following Medical Subject Headings: 'acute pancreatitis, necrosis, mortality, pathogenesis, incidence' and the terms 'open necrosectomy and minimally invasive necrosectomy'.The National Institute of Clinical Excellence(NICE) Guidelines were also included in our study. Inclusion criteria for our clinical review included established guidelines, randomized controlled trials and non-randomized controlled trials with a follow-up duration of more than 6 weeks.RESULTS: The incidence of severe acute pancreatitis within the UK is significantly rising and pathogenetic theories are still controversial. In developed countries, the most common cause is biliary calculi. The British Society of Gastroenterology,acknowledges the Revised Atlanta criteria for prediction of severity. A newer Determinant-based system has been developed.The principle of surgical management of acute necrotizing pancreatitis requires intensive care management, identifying infection and if indicated, debridement of any infected necrotic area. The current procedures opted for include standard surgical open necrosectomy, endoscopic necrosectomy and minimally invasive necrosectomy. The current paradigm is shifting towards a step-up approach.CONCLUSIONS: Severe acute pancreatitis is still a subject of grey areas in its surgical management even though new studies have been recorded since the origin of the latest UK guidelines for management of severe acute pancreatitis. | Mark Portelli Christopher David Jones | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 201 |
| 8 | A general-purpose machine learning framework for predicting properties of inorganic materials显示文摘A very active area of materials research is to devise methods that use machine learning to automatically extract predictive models from existing materials data.While prior examples have demonstrated successful models for some applications,many more applications exist where machine learning can make a strong impact.To enable faster development of machine-learning-based models for such applications,we have created a framework capable of being applied to a broad range of materials data.Our method works by using a chemically diverse list of attributes,which we demonstrate are suitable for describing a wide variety of properties,and a novel method for partitioning the data set into groups of similar materials to boost the predictive accuracy.In this manuscript,we demonstrate how this new method can be used to predict diverse properties of crystalline and amorphous materials,such as band gap energy and glass-forming ability. | Logan Ward Ankit Agrawal Alok Choudhary Christopher Wolverton | 2016 | npj Computational Materials2016，，1： | 83 |
| 9 | 3D GIS与3D GMS中的空间构模技术显示文摘3DGIS和3DGMS是近10a来地学领域并行发展的两大领域。该文从研究对象、数据来源、空间参照、空间构模、拓扑描述、空间量算、空间分析及应用领域等方面分析了3DGIS和3DGMS异同,并从数学模型、高程特征、属性特征和构模方式等方面讨论并重新界定了空间维数问题。重点分析了空间构模技术,将3DGIS和3DGMS中的空间构模分为基于面模型、基于体模型和混合构模3大类,并进行了分析比较和讨论。指出3DGIS和3DGMS将殊途同归,并最终建立全要素的真3D地球信息系统。 | 吴立新 史文中 Christopher Gold | 2003 | 地理与地理信息科学2003，19，1： | 172 |
| 10 | 从AO传统加压接骨板到新型内固定器原则显示文摘骨折内固定中生物学的重要性和保护骨和软组织,作为AO的第4项原则已受重视。AO传统加压接骨板对骨面的压迫会干扰骨皮质的血运,引起接骨板下方骨的结构性改变。有限接触动力加压接骨板(LC-DCP)可减小接骨板和骨的接触面积。锁定螺丝钉(LHS)、点接触固定器(PCFix)及微创固定系统(LISS)设计则因接骨板与骨面无接触和压迫,是新的一次变革。这种内固定器原理的概念可以用外固定支架来理解,可以防止任何对骨血运的破坏,其稳定性依赖于螺丝钉-接骨板组合的成角稳定性。带有锁定螺丝钉的新型微创固定系统(LISS)和锁定加压接骨板(LCP)可以为现代骨折手术治疗提供新的选择方法,是微创经皮接骨板技术(MIPO)的理想材料,并可以在疏松骨质内得到相当好的固定强度。然而,必须指出这些新型接骨板和螺丝钉并不能解决所有的问题,特别是在处理干骺端和骨干部骨折时,它们每一步的操作都需要有非常仔细的计划,包括重温AO经典的原则。 | Thomas P.Rüedi(托马斯.鲁迪) Christoph Sommer(克利斯托夫.邵墨) 罗炯 顾立强 | 2003 | 中华创伤骨科杂志2003，5，3： | 169 |
| 11 | 气候变化下水资源脆弱性的适应性管理新认识显示文摘气候变化下的水资源脆弱性和适应性管理研究成为全球和国家应对气候变化和保障水资源安全重点关注的问题,也是中国可持续发展面对的重大战略问题。介绍了水资源脆弱性和适应性管理的国内外最新研究进展;针对国家重大需求和国际科学前沿问题,综述了气候变化下水资源脆弱性和适应性管理存在的问题与挑战。提出了气候变化下水资源脆弱性与适应性管理理论与方法研究以应对气候变化的无悔为准则,与社会经济可持续发展、成本效益分析、利益相关者的多信息源的分析与综合决策相结合为原则,对适应性管理与脆弱性组成的互联互动系统及其风险与不确定性进行分析的新认识。 | 夏军 石卫 雒新萍 洪思 宁理科 Christopher J Gippel | 2015 | 水科学进展2015，26，2： | 68 |
| 12 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 13 | 小腿部主要穿支的形态学分析与皮瓣设计显示文摘目的:探讨小腿部穿支的出现规律,为临床提供良好的皮瓣切取部位、简单易行的皮瓣切取方法。方法:(1)6具(12侧)动脉灌注明胶-氧化铅混悬液的新鲜成人整尸标本,解剖取下整个下肢被覆组织拍摄X线片,观测皮动脉的数量以及彼此间的吻合情况等。利用Photoshop与ScionImage分析穿支供血的趋向性,血管密度变化趋势及每个分支的供血面积等。(2)红色乳胶灌注的下肢标本26侧,解剖观测外径≥0.5mm的穿支,测量其管径及其走行,分支、分布情况等。结果:每侧小腿部有外径≥0.5mm的穿支(30±13)支。其被覆组织内有4条明显的营养血管链沿皮神经及浅静脉分布。其中小腿内侧穿支的外径为(0.8±0.2)mm,供血面积为(32.6±13.3)cm2,总供皮面积可达293cm2。结论:小腿部单个穿支的供血面积较小,但由于血管链的存在而可以极方便的拓展小腿部皮瓣的裁取面积;小腿内侧及后部营养血管链紧邻,可互为解剖学供区与动力学供区。 | 梅劲 任家武 楼新法 戴开宇 崔怀瑞 胡斯旺 Christopher R.Geddes 唐茂林 | 2006 | 中国临床解剖学杂志2006，24，3： | 59 |
| 14 | 应用放射造影术进行血管3D可视化研究初探显示文摘目的:探索一种新的、更精细且简便易行的血管3D可视化研究技术。方法:利用改良的明胶-氧化铅血管标识技术更精细的标识动脉血管,CT扫描后应用3D-Doctor(演示版)软件经计算机处理以获得三维数码图像。结果:利用3D-Doctor获得了非常清晰的血管三维重建图像,诸如大脑前动脉的分支,耳前、耳后动脉,耳动脉的三级分支等小血管均清晰可辨。结论:应用氧化铅标识血管后,可非常方便地对血管进行定位,分割与配准等3D可视化研究。较之其它的三维重建方法而言,此法简便易行、快捷,可在几分钟内轻松地完成局部血管的三维重建。 | 张志浩 李严斌 梅劲 彭田红 Christopher R.Geddes 唐茂林 | 2006 | 中国临床解剖学杂志2006，24，3： | 52 |
| 15 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 16 | 保持围手术期体温正常 一种减少手术并发症的简单、安全和有效的方法显示文摘围手术期低体温的危害尚未引起人们的重视,这种危害包括伤口感染率、心血管并发症和失血量的增加,以及病人的恢复和住院时间延长。而保持病人的体温在36℃或以上是有益的并可节省费用。 Frank等人对接受胸部。 | Christopher Mark Harper Thomas McNicholas S Gowrie-Mohan 黄宇光 | 2003 | 英国医学杂志中文版2003，6，4： | 51 |
| 17 | Risk of cardiovascular,cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has emerged as a public health problem of epidemic proportions worldwide.Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease(CHD),abnormalities of cardiac function and structure(e.g.,left ventricular dysfunction and hypertrophy,and heart failure),valvular heart disease(e.g.,aortic valve sclerosis)and arrhythmias(e.g.,atrial fibrillation).Experimental evidence suggests that NAFLD itself,especially in its more severe forms,exacerbates systemic/hepatic insulin resistance,causes atherogenic dyslipidemia,and releases a variety of pro-inflammatory,pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications.Collectively,these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications.The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular,cardiac and arrhythmic complications,to briefly examine the putative biological mechanisms underlying this association,and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications. | Stefano Ballestri Amedeo Lonardo Stefano Bonapace Christopher D Byrne Paola Loria Giovanni Targher | 2014 | World Journal of Gastroenterology2014，20，7： | 55 |
| 18 | 基于小波多尺度分析的奇性指数:一种新地震属性显示文摘传统的地震解释主要是观测地震振幅及相位的变化,但是地震振幅也会掩盖地下介质中真实的地质情况.在许多情况下,重要的地质信息可能是通过与振幅特征无关的奇异性参数来传递的.本文提出奇异性指数,即Hlder指数α(又被称为Lipschitz指数),可以作为一种新的地震属性,它能够准确反映数据中的奇点的位置和奇异性强度.Hlder指数α是对某一点上或某一点周围很小的范围内的奇异性强度的度量,大的α值表示低的奇异性(或高的正则性).研究表明α可以作为一种自然的能够精确刻画地层边界的地震属性.本文根据这一思想,对合成和实测的地震数据进行了小波基础上的多尺度分析研究,结果表明由本文的算法得到的α提高了对地层边界划分的能力,而这些地层界面在传统的地震振幅显示则不明显. | 李春峰 Christopher Liner | 2005 | 地球物理学报2005，48，4： | 46 |
| 19 | Contrast-enhanced endoscopic ultrasound in discrimination between focal pancreatitis and pancreatic cancer显示文摘瞄准:作为基于微容器的灌注特征把发炎区分开来与胰腺的癌的一个方法评估提高对比的 endosonography。方法:在有怀疑的慢性胰炎的 86 个病人(变老:62+/-12 年;性别:f/m 38/48 ) ,胰腺的损害被常规内视镜的 B 模式,力量 Doppler 超声和提高对比的力量模式检验(日立 EUB 525, SonoVue, 2.4 mL, Bracco ) 用为恶意的损害的下列标准:用常规力量 Doppler 的没有可检测的 vascularisation 在用 SonoVue 提高对比的技术和没有可检测的静脉的容器里面的短距离上的动脉的容器的扫描、不规则的外观损害。如果所有标准是可检测的,恶意的损害被假定[内视镜的超声(EUS ) 指导了的标准答案好针渴望细胞学,操作] 。没有瘤形成的慢性胰炎的标准在 SonoVue 的注射前被定义为没有可检测的 vascularisation,在在 SonoVue 的注射和动脉、静脉的容器的察觉以后的至少 20 公里的距离上的容器的常规外观。结果:常规 EUS 的敏感和特性为胰腺的癌症分别地是 73.2% 和 83.3% 。与恶意的胰腺的损害和特性在 56 个病人中的 51 个增加到 91.1% 的提高对比的 EUS 的敏感与长期的煽动性的胰腺的疾病在 30 个病人中的 28 个增加了到 93.3% 。结论:提高对比的内视镜的超声改进在慢性胰炎和胰腺的癌之间的区别。 | Michael Hocke Ewald Schulze Peter Gottschalk Theodor Topalidis Christoph F Dietrich | 2006 | World Journal of Gastroenterology2006，12，2： | 43 |
| 20 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
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