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| 1 | 单向复合材料单搭接粘结节点的破坏预测及增强显示文摘提出了一种预测复合材料单搭接粘结节点在复合材料本体和粘结界面上破坏的方法。该方法采用了粘结剂和分层破坏判断的一个完全弹塑性模型,采用有限元方法和本文方法进行破坏预测。预测结果显示:破坏模式和强度都与各种粘结方法和参数下进行的节点模型试验结果吻合很好。基于数值分析,建立最佳节点强度条件,并提出一种新的提高节点强度的方法。验证结果表明:该方法可显著提高节点强度。 | Kwang-Soo Kim Yeong-Moo Yi Gwang-Rae Cho Chun-Gon Kim | 2008 | 钢结构2008，23，7： | 13 |
| 2 | Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy显示文摘Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer immunotherapy.DCs require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 responses.DCs play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of DCs.We investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions occur.DCs that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce IL-12p70.NK cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte responses.Our data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy. | Thanh-Nhan Nguyen-Pham Deok-Hwan Yang Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee | 2012 | Cellular & Molecular Immunology2012，9，1： | 8 |
| 3 | 韩国中年男性血清25-羟维生素D水平与皋酮缺乏:一项横向研究显示文摘原先的研究证明,男性性腺机能减退与维生素D低水平有关。然而,有关韩国男性维生素D对睾酮水平影响的研究尚未见报道。本研究的目的在于探讨睾酮的水平是否与血清维生素D水平相关,以及是否存在季节性变化。本横向研究分析了652名40岁以上韩国男性的血清25.羟维生素D[25(OH)D]、总睾酮(TT)以及游离睾酮(FT)水平。这些男性都经过了全面的体检。受试者的平均年龄56.7±7.9岁,平均血清血25.羟维生素D、总睾酮以及游离睾酮水平分别为21.23±7.9ngml-1,4.70±1.6ngml-1和8.12±3.3pgml-1。在多元线性回归模型,25.羟维生素D与总睾酮水平(B=O.137,P〈O.001)以及游离睾酮水平(B=0.103,P=O.008)呈现正相关。在调整了年龄因素之后,25.羟维生素D与游离睾酮水平之间呈现相似的季节性变化或月变化。在调整了年龄、季节、体重指数、身体成分、慢性疾病、吸烟以及饮酒等因素之后,维生素D缺乏[25(OH)D〈20ngml-1]与总睾酮水平缺乏(〈2.30ngml-1)的风险增高(风险率[OR]:2.65;95%可信区间:1.21—5.78,P=0.014)以及游离睾酮水平缺乏(〈6.50Pgml-1)的风险增高(OR:1.44;95%可信区间:1.01-2.06,P=O.048)相关。综上所述,我们证明了韩国男性血清25.羟维生素D与睾酮水平之间的正相关,并呈现季节性波动。 | Young Jin Tak Jeong Gyu Lee Yun Jin Kim Nam Cheol Park Sang Soo Kim Sangyeoup Lee Byung Mann Cho Eun Hee Kong Dong Wook Jung Yu Hyeon Yi | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 4 | Post-transplantation sequential entecavir monotherapy following 1-year combination therapy with hepatitis B immunoglobulin显示文摘 | Nam-Joon Yi Jong Young Choi Kyung-Suk Suh Jai Young Cho Minjung Baik Geun Hong Kwang-Woong Lee Won Kim Yoon Jun Kim Jung-Hwan Yoon Hyo-Suk Lee Dong Goo Kim | 2013 | Journal of Gastroenterology2013，，12： | 3 |
| 5 | A revised scoring system utilizing serum alphafetoprotein levels to expand candidates for living donor transplantation in hepatocellular carcinoma显示文摘 | Sung Hoon Yang Kyung-Suk Suh Hae Won Lee Eung-Ho Cho Jai Young Cho Yong Beom Cho In Hwan Kim Nam-Joon Yi Kuhn Uk Lee | 2007 | Surgery2007，，5： | 3 |
| 6 | Study protocol of the Asian XELIRI ProjecT(AXEPT):a multinational,randomized,non-inferiority,phase Ⅲ trial of second-line chemotherapy for metastatic colorectal cancer, comparing the eicacy and safety of XELIRI with or without bevacizumab versus FOLFIRI w显示文摘Background: Capecitabine and irinotecan combination therapy(XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer(m CRC). Recently, in the Association of Medical Oncology of the German Cancer Society(AIO) 0604 trial, tri?weekly XELIRI plus bevacizumab, with reduced doses of irinotecan(200 mg/m^2 on day 1) and capecitabine(1600 mg/m^2 on days 1–14), repeated every 3 weeks, has shown favorable tolerability and eicacy which were comparable to those of capecitabine and oxaliplatin(XELOX) plus bevacizumab. The doses of capecit?abine and irinotecan in the AIO trial are considered optimal. In a phase I/II study, XELIRI plus bevacizumab(BIX) as second?line chemotherapy was well tolerated and had promising eicacy in Japanese patients.Methods: The Asian XELIRI Projec T(AXEPT) is an East Asian collaborative, open?labelled, randomized, phase Ⅲ clinical trial which was designed to demonstrate the non?inferiority of XELIRI with or without bevacizumab versus standard FOLFIRI(5?fluorouracil, leucovorin, and irinotecan combination) with or without bevacizumab as second?line chemo?therapy for patients with m CRC. Patients with 20 years of age or older, histologically conirmed m CRC, Eastern Coop?erative Oncology Group performance status 0–2, adequate organ function, and disease progression or intolerance of the irst?line regimen will be eligible. Patients will be randomized(1:1) to receive standard FOLFIRI with or with?out bevacizumab(5 mg/kg on day 1), repeated every 2 weeks(FOLIRI arm) or XELIRI with or without bevacizumab(7.5 mg/kg on day 1), repeated every 3 weeks(XELIRI arm). A total of 464 events were estimated as necessary to show non?inferiority with a power of 80% at a one?sided α of 0.025, requiring a target sample size of 600 patients. The 95% conidence interval(CI) upper limit of the hazard ratio was pre?speciied as less than 1.3.Conclusion: The Asian XELIRI Projec T is a multinational phase III trial being conducted to provide evidence for XELIRI with or without bevacizumab as a second?line treatment option of mCRC. | Masahito Kotaka Ruihua Xu Kei Muro Young Suk Park Satoshi Morita Satoru Iwasa Hiroyuki Uetake Tomohiro Nishina Hiroaki Nozawa Hiroshi Matsumoto Kentaro Yamazaki Sae-Won Han Wei Wang Joong Bae Ahn Yanhong Deng Sang-Hee Cho Yi Ba Keun-Wook Lee Tao Zhang Taroh Satoh Marc E.Buyse Baek-Yeol Ryoo Lin Shen Junichi Sakamoto Tae Won Kim | 2016 | Chinese Journal of Cancer2016，35，12： | 3 |
| 7 | Health behaviors of Korean adults with hepatitis B:Findings of the 2016 Korean National Health and Nutrition Examination Survey显示文摘AIM To assess the frequencies of five health-related behaviors(smoking, alcohol consumption, body weight, sleep dura-tion, and physical activity) in Korean adults with chronic hepatitis B.METHODS Data were obtained from the 2016 Korean National Health and Nutrition Examination Survey. In total, 5887 subjects(2568 males, 3319 females) over 19 years old were enrolled in this study. Interviews were performed to obtain information on demographic characteristics and medical conditions. A self-administered questionnaire and medical examination were used to assess the smoking history, alcohol use, physical activity, sleep duration, and body weight of the subjects. Chronic hepatitis B was diagnosed based on detection of hepatitis B surface antigen(HBs Ag). The subjects were categorized into HBs Ag positive and negative groups, and a complex sampling analysis was conducted to compare the health behaviors between these groups.RESULTS Among males, the current smoking rate in the HBs Ag positive group was higher than that in the negative group(45.5% vs 38.5%). In the positive group, the rates of monthly and high-risk alcohol use were 70.4% and 17.6% in males and 45.9% and 3.8% in females, respectively. The rate of alcohol use was similar between the two groups [P = 0.455(males) and P = 0.476(females)]. In the HBs Ag positive group, 32.3% and 49.9% of males and 26.5% and 49.6% of females were overweight and physically inactive, respectively. High-risk alcohol consumption and physical inactivity were significantly associated with self-perceived health status.CONCLUSION Our data demonstrate that a large proportion of Korean adults with chronic hepatitis B have poor health behaviors. Further studies are needed to confirm our results. | Yu-Hyeon Yi Yun-Jin Kim Sang-Yeoup Lee Byung-Mann Cho Young-Hye Cho Jeong-Gyu Lee | 2018 | World Journal of Gastroenterology2018，24，28： | 3 |
| 8 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?显示文摘 | Yi Young Kim Seong Woo Jeon JiYeon Kim Jung Chul Park Kwang Bum Cho Kyung Sik Park EunSoo Kim Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Kyeong Ok Kim ByungIk Jang Si Hyung Lee Chang Hun Yang | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 9 | Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen speciesmediated DNA damage and apoptosis in PC12 cells显示文摘Amyloid beta(Aβ)-induced oxidative stress is a major pathologic hallmark of Alzheimer's disease. Cyanidin, a natural flavonoid compound, is neuroprotective against oxidative damage-mediated degeneration. However, its molecular mechanism remains unclear. Here, we investigated the effects of cyanidin pretreatment against Aβ-induced neurotoxicity in PC12 cells, and explored the underlying mechanisms. Cyanidin pretreatment significantly attenuated Aβ-induced cell mortality and morphological changes in PC12 cells. Mechanistically, cyanidin effectively blocked apoptosis induced by Aβ, by restoring the mitochondrial membrane potential via upregulation of Bcl-2 protein expression. Moreover, cyanidin markedly protected PC12 cells from Aβ-induced DNA damage by blocking reactive oxide species and superoxide accumulation. These results provide evidence that cyanidin suppresses Aβ-induced cytotoxicity, by preventing oxidative damage mediated by reactive oxide species, which in turn inhibits mitochondrial apoptosis. Our study demonstrates the therapeutic potential of cyanidin in the prevention of oxidative stress-mediated Aβ neurotoxicity. | Yi Wang Xiao-ting Fu Da-wei Li Kun Wang Xin-zhi Wang Yuan Li Bao-liang Sun Xiao-yi Yang Zun-cheng Zheng Nam Chun Cho | 2016 | Neural Regeneration Research2016，11，5： | 3 |
| 10 | Laser micromachining of CNT/Fe/Al_2O_3 nanocomposites显示文摘CNT/Fe/Al2O3 mixed powders were synthesized from Fe/Al2O3 nanopowders using thermal CVD for the homogeneous dispersion of carbon nanotubes CNTs. CNTs consisted of MWNT, and the diameter was approximately 20-30 nm. After sintering, CNTs were homogenously located throughout Al2O3 grain boundary and were buckled. A femto-second laser installed with special optical systems was used for micromachining of the nanocomposites. The relationship between material ablation rate and energy fluence was theoretically investigated and compared with experimental results from cross-sectional SEM analysis. The nanocomposites which have higher content of CNT show a fairly good machining result due to its higher thermal conductivity and smaller grain size as well as lower light transmittance. | Kwang-Ryul KIM Byoung-Deog CHOI Jun-Sin YI Sung-Hak CHO Yong-Ho CHOA Dong-Soo SHIN Dong-Ho BAE Myung-Chang KANG Young-Keun JEONG | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 2 |
| 11 | Zircon U–Pb geochronology and Hf isotope geochemistry of magmatic and metamorphic rocks from the Hida Belt, southwest Japan显示文摘Zircon U–Pb and Hf isotope data integrated in this study for magmatic and metamorphic rocks fromthe Hida Belt,southwest Japan,lead to a new understanding of the evolution of the Cordilleran arc system along the ancestral margins of present-day Northeast Asia.Ion microprobe data for magmatic zircon domains from eight mafic tointermediate orthogneisses in the Tateyama and Tsunogawa areas yielded weighted mean 206Pb/238U ages spanning the entire Permian period(302–254 Ma).Under cathodoluminescence,primary magmatic growth zones in the zircon crystals were observed to be partially or completely replaced by inward-penetrating,irregularly curved featureless or weakly zoned secondary domains that mostly yielded U–Pb ages of 250–240 Ma and relatively high Th/U ratios(>0.2).These secondary domains are considered to have been formed by solid-state recrystallization during thermal overprints associated with intrusions of Hida granitoids.Available whole-rock geochemical and Sr–Nd isotope data as well as zircon age spectra corroborate that the Hida Belt comprises the Paleozoic–Mesozoic Cordilleran arc system built upon the margin of the North China Craton,together with the YeongnamMassif in southern Korea.The arcmagmatismalong this systemwas commenced in the Carboniferous and culminated in the Permian–Triassic transition period.Highly positiveεHf(t)values(>+12)of late Carboniferous to early Permian detrital zircons in the Hida paragneisses indicate that there was significant input from the depleted asthenospheric mantle and/or its crustal derivatives in the early stage of arc magmatism.On the other hand,near-chondriticεHf(t)values(+5 to−2)of magmatic zircons from late Permian Hida orthogneisses suggest a lithospheric mantle origin.Hf isotopic differences between magmatic zircon cores and the secondary rims observed in some orthogneiss samples clearly indicate that the zircons were chemically open to fluids or melts during thermal overprints.Resumed highly positive zirconεHf(t)values(>+9)shared by Early Jurassic granitoids in the Hida Belt and Yeongnam Massif may reflect reworking of the Paleozoic arc crust. | Deung-Lyong Cho Tae-Ho Lee Yutaka Takahashi Takenori Kato Keewook Yi Shinae Lee Albert Chang-sik Cheong | 2021 | Geoscience Frontiers2021，12，4： | 2 |
| 12 | Clinical outcomes of metastatic breast cancer patients with triple-negative phenotype who received platinumcontaining chemotherapy显示文摘 | Yi S Uhm J Cho E | 2008 | J Clin Oncol2008，26，15： | 1 |
| 13 | Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling显示文摘 | Yi T Yi Z Cho SG | 2008 | Cancer Res2008，68，6： | 1 |
| 14 | Clinical outcomes of metastatic breast can-cer p8tients with triple-negative phenol type who received platinumcontaining chemotherapy显示文摘 | Yi S Uhm J Cho E | 2008 | J ClinOneol2008，26，： | 1 |
| 15 | Skeletodental factors affecting chin point deviation in female patients with class III malocclusion and facial asymmetry:a three-dimensional a-nalysis using computed tomography 显示文摘 | BaekSH Cho IS Chang YI | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，104，5： | 1 |
| 16 | The role of 18F‐FDG‐PET imaging for the selection of liver transplantation candidates among hepatocellular carcinoma patients显示文摘 | Sung Hoon Yang Kyung‐Suk Suh Hae Won Lee Eung‐Ho Cho Jai Young Cho Yong Beom Cho Nam‐Joon Yi Kuhn Uk Lee | 2006 | Liver Transpl2006，，11： | 1 |
| 17 | Delayed fatal cerebellar hemorrhage caused by hemangioblastoma after successful radiosurgical treatment 显示文摘 | Chun YI Cho J Moon CT | 2010 | Acta neurochirurgica2010，152，9： | 1 |
| 18 | A rice dehydration-inducible SNF1-related protein kinase 2 phosphorylates an abscisic acid responsive element-binding factor and associates with ABA signaling显示文摘 | Min-Ju Chae Jung-Sook Lee Myung-Hee Nam Kun Cho Ji-Yeon Hong Sang-A Yi Seok-Cheol Suh In-Sun Yoon | 2007 | Plant Molecular Biology2007，，2： | 1 |
| 19 | Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure- activity relationships, and antitumor activities of 2- indolinone derivatives显示文摘 | Tang Peng Cho Su Yi Oong Feng Jun | 2010 | Journal of medicinal chemistry2010，53，22： | 1 |
| 20 | I-Iemorheology and microvascular disorders 显示文摘 | Cho YI Cho DJ | 2011 | Kore- an Circ J2011，41，6： | 1 |
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