|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas orvzae pv. orvzae in Rice显示文摘 | Ying Peng Laura E. Bartley Xuewei Chen Christopher Dardick Mawsheng Chern Randy Ruan Patrick E. Canlas Pamela C. Ronald | 2008 | Molecular Plant2008，1，3： | 39 |
| 2 | An XA21-Associated Kinase (OsSERK2) Regulates Immunity Mediated by the XA21 and XA3 Immune Receptors显示文摘米饭 XA21 有免疫力的受体 kinase 和在结构上联系了 XA3 受体授与免疫到 Xanthomonas oryzae pv。oryzae (Xoo ) ,细菌的叶老家的原因的代理人。这里,我们报导 OsSERK2 的隔离(米饭体的 embryogenesis receptorkinase 2 ) 并且证明 OsSERK2 断然调整免疫由 XA21 和 XA3 以及米饭免疫者 receptorFLS2 (OsFLS2 ) 调停了。为 OsSerk2 显示的瑞斯植物 silenced 改变了形态学并且把敏感归结为荷尔蒙 brassinolide。OsSERK2 在酵母与每有免疫力的受体的 intracellulardomains 交往以一种 kinase 活动依赖者方式的二混血儿的系统。OsSERK2 在 vitro 与 XA21 经历 bidirectionaltransphosphorylation 并且在 vivo 与 XA21 形成组成的建筑群。这些结果在三米饭免疫者受体的功能为 OsSERK2 表明一个必要角色并且建议和米饭免疫者受体的 thatdirect 相互作用为他们的功能是批评的。一起拿,我们的调查结果建议米饭 XA21, XA3,和 FLS2 的反省 OsSERK2 的规定的 thatthe 机制不同于 AtSERK3/BAK1-mediated regulationof Arabidopsis FLS2 和 EFR.Key 词的: | Xuewei Chena Shimin Zuo Benjamin Schwessinger Mawsheng Chern Patrick E. Canlas Deling Ruan Xiaogang Zhou Jing Wang Arsalan Daudi Christopher J. Petzold Joshua L. Heazlewood Pamela C. Ronald | 2014 | Molecular Plant2014，7，5： | 17 |
| 3 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018，45，12： | 7 |
| 4 | The isometric extension of “into” mappings on unit spheres of AL-spaces显示文摘In this paper, we show that if V0 is an isometric mapping from the unit sphere of an AL-space onto the unit sphere of a Banach space E, then V0 can be extended to a linear isometry defined on the whole space. | DING GuangGui School of Mathematics Science, Chern Institute of Mathematics and LPMC, Nankai University, Tianjin 300071, China | 2008 | Science China Mathematics2008，51，10： | 7 |
| 5 | Deciphering Rice Lesion Mimic Mutants to Understand Molecular Network Governing Plant Immunity and Growth显示文摘Plant lesion mimic mutants(lmms)generally possess autoimmunity and hypersensitive response(HR)-like cell death in the absence of biotic or abiotic stress.They have attracted much attention because they are useful tools for deciphering the interaction between defense signaling and growth.Recent studies have identified more than 30 lmms involved in the plant immune response and cell death in rice.Genes underlying these lmms,coding for diverse types of proteins,mainly regulate transcription,protein translation and modification,vesicular trafficking and catalyzation of metabolism.Here,we presented an overview of the most recent advances on the study of lmms in rice and proposed a perspective on potential utilization of LMM genes in agriculture. | ZHU Xiaobo ZE Mu CHERN Mawsheng CHEN Xuewei WANG Jing | 2020 | Rice science2020，27，4： | 7 |
| 6 | The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity显示文摘A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes,opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation,C1q also regulates cell differentiation,adhesion,migration,activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article,we discuss the basic properties of C1q,its expression,and classical and regulatory functions. | Jinhua Lu Boon King Teh Linda Wang Yinan Wang Yen Seah Tan Min Chern Lai Kenneth B. M. Reid | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 7 | Optimized back-analysis for tunneling-induced ground movement using equivalent ground loss model显示文摘 | Shue-Yeong Chi Jin-Ching Chern Chin-Cheng Lin | 2001 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2001，，3： | 3 |
| 8 | Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer显示文摘Objective:Heat shock protein 47(HSP47)is a collagen-specific molecular chaperone that facilitates collagen maturation.Its role in cancer remains largely unknown.In this study,we investigated the roles o f HSP47 in colorectal cancer(CRC)and therapy resistance.Methods:Expression o f HSP47 in CRC tissues was examined(1)in paired human CRC/adjacent normal tissues,using real time quantitative reverse transcription polymerase chain reaction(qRT-PCR),The Cancer Genome Atlas(TCGA)database,and 22 independent m icroarray databases(curated CRC).In vitro studies on several CRC cell lines(H C T 116,RKO and C C L228)with modulated HSP47 expression were conducted to assess cell viability and apoptosis(TU N EL assay and caspase-3/-7)during exposure to chemotherapy.AKT signaling and co-imm unoprecipitation studies were performed to examine HSP47 and PHLPP1 interaction.In vivo studies using tumor xenografts were conducted to assess the effects of HSP47 modulation on tum or growth and therapy response.Results:HSP47 was upregulated in CRC and was associated with poor prognosis in individuals with CRC.In vitro,HSP47 overexpression supported the survival of CRC cells,whereas its knockdown sensitized cells to 5-fluorouracil(5-FU).HSP47 promoted survival by inhibiting apoptosis,enhancing AKT phosphorylation,and decreasing expression of the AKT-specific phosphatase PHLPP1 when cells were exposed to chemotherapy.These effects were partly results of the interaction between HSP47 and PHLPP1,which decreased PHLPP1 stability and led to more persistent AKT activity.In vivoy HSP47 supported tumor growth despite 5-FU treatment.Conclusions:HSP47 supports the growth of CRC tumors and suppresses the efficacy of chemotherapy via modulation of AKT signaling. | Yijye Chern Peter Zhang Hyelim Ju Isabella T.Tai | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 9 | Thymoquinone: Potential cure for inflammatory disorders and cancer显示文摘 | Chern Chiuh Woo Alan Prem Kumar Gautam Sethi Kwong Huat Benny Tan | 2011 | Biochemical Pharmacology2011，，4： | 2 |
| 10 | Evidence for a disease-resistance pathway in rice similar to the NPR1-mediated signaling pathway in Arabidopsis显示文摘 | Chern M S Fitzgerald H A Yadav R C | 2001 | Plant J2001，27，2： | 2 |
| 11 | Efficient solvent extraction of antioxidant-rich extract from a tropical diatom,Chaetoceros calcitrans (Paulsen) Takano 1968显示文摘Objective: To compare the in vitro antioxidant capacity of a diatom, Chaetoceros calcitrans(C. calcitrans) extracted using six types of solvents.Methods: Each extract was evaluated in terms of extraction yield, total carotenoid,fucoxanthin content, total phenolic and antioxidant capacities(DPPH and ABTS +scavenging activity and iron chelating activity).Results: The methanol extract exhibited the highest yield [(22.71 ± 0.96) g/100 g dry weight(DW)], total carotenoid [(4.46 ± 0.36) mg/g DW], total phenolic [(2.49 ± 0.08) mg gallic acid equivalents/g DW] and second highest fucoxanthin content [(2.08 ± 0.03) mg fucoxanthin/g DW] as compared to other solvent extracts. Methanolic extract also exhibited significantly higher(P < 0.05) scavenging(DPPH, ABTS +) and iron chelating activities.Conclusions: Methanol was the recommended solvent for the production of antioxidant rich extract from C. calcitrans. Both carotenoids and phenolic acids were found to be positively correlated to the antioxidant capacities of C. calcitrans. Lead bioactives confirmed by subsequent high performance liquid chromatography studies were fucoxanthin, gallic acid and protocatechuic acid. | Su Chern Foo Fatimah Md.Yusoff Maznah Ismail Mahiran Basri Nicholas Mun Hoe Khong Kim Wei Chan Sook Kun Yau | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 2 |
| 12 | Strong Suppression of Systemic Acquired Resistance in Arabidopsis by NRR is Dependent on its Ability to Interact with NPRland its Putative Repression Domain显示文摘 | Mawsheng Chern Patrick E. Canlas Pamela C. Ronald | 2008 | Molecular Plant2008，1，3： | 2 |
| 13 | 采用动态偏离份额分析法来评价新加坡的出口竞争力显示文摘本文采用动态偏离份额分析法来研究1988—2001年期间新加坡的电子产品和化工产品在美国、欧盟和日本出口市场上的出口业绩。它把新加坡的出口竞争地位和一系列参照经济进行比较,这些经济包括中国、香港、韩国、马来西亚和中国台湾省,它们在上述市场是密切的竞争者。 | 彼得.威尔逊 Ting Su Chern Tu Suh Ping 爱德华.鲁滨逊 齐顺然 | 2007 | 南洋资料译丛2007，，2： | 2 |
| 14 | High dielectric permittivity and hole-doping effect in La1-x Srx FeO3 显示文摘 | CHERN G HSIEH W K | 1998 | Phy Rev B1998，58，3： | 2 |
| 15 | Cytotoxicity and reversal of multidrug resistance by tryptanthrin-derived indoloquinazolines显示文摘 | Sung-tsai YU Ji-wang CHERN Tzer-ming CHEN Yi-fan CHIU Hui-ting CHEN Yen-hui CHEN | 2010 | Acta Pharmacologica Sinica2010，31，2： | 2 |
| 16 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 17 | Ultrasonography for Diagnosing Carpal Tunnel Syndrome: A Meta-Analysis of Diagnostic Test Accuracy显示文摘 | Ta-Wei Tai Cheng-Yi Wu Fong-Chin Su Tai-Chang Chern I-Ming Jou | 2012 | Ultrasound in Medicine & Biology2012，，7： | 2 |
| 18 | Cerebral dural arteriovenous fistulas presenting as pulsatile tinnitus显示文摘 | CHEN Y J HOW C K CHERN C H | 2007 | Intern Med J2007，37，： | 1 |
| 19 | Vertebral artery dissection and cerebellar infarction following chiropractic manipulation显示文摘 | Chen WL Chern CH Wu YL | 2006 | Emerg Med J2006，23，1： | 1 |
| 20 | Mediators of hypersensitivity pneumonitis显示文摘 | Schuyler M Gott K Cherne A | 2000 | J Lab Clin Med2000，136，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员