|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current and emerging therapies in unresectable and recurrent gastric cancer显示文摘Gastric cancer is one of the most lethal cancers worldwide despite many advances and options in therapy. As it is often diagnosed at an advanced stage, prognosis is poor with a median overall survival of less than twelve months. Chemotherapy remains the mainstay of treatment for these patients but it confersonly a moderate survival advantage. There remains a need for new targeted treatment options and a way to better define patient populations who will benefit from these agents. In the past few years, there has been a better understanding of the biology, molecular profiling, and heterogeneity of gastric cancer. Our increased knowledge has led to the identification of gastric cancer subtypes and to the development of new targeted therapeutic agents. There are now two new targeted agents, trastuzumab and ramucirumab, that have recently been approved for the treatment of advanced and metastatic gastric cancer. There are also many other actively investigated targets, including epidermal growth factor receptor, the phosphatadylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, c-Met, poly ADP-ribose polymerase, and immune checkpoint inhibition. In this review, we discuss the current management of advanced gastric cancer as well as emerging targeted therapies and immunotherapy. | Erin Jou Lakshmi Rajdev | 2016 | World Journal of Gastroenterology2016，22，20： | 20 |
| 2 | Fetal brain tumors:Prenatal diagnosis by ultrasound and magnetic resonance imaging显示文摘Congenital central nervous system tumors diagnosed during pregnancy are rare, and often have a poor prognosis. The most frequent type is the teratoma. Use of ultrasound and magnetic resonance image allows the suspicion of brain tumors during pregnancy. However, the definitive diagnosis is only confirmed after birth by histology. The purpose of this mini-review article is to describe the general clinical aspects of intracranial tumors and describe the main fetal brain tumors. | Herbene Jose Milani Edward Araujo Junior Sergio Cavalheiro Patrícia Soares Oliveira Wagner Jou Hisaba Enoch Quindere Sa Barreto Maurício Mendes Barbosa Luciano Marcondes Nardozza Antonio Fernandes Moron | 2015 | World Journal of Radiology2015，7，1： | 7 |
| 3 | Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma显示文摘High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma(HCC)cohorts confirmed previously identified frequently mutated somatic genes,such as TP53,CTNNB1 and AXIN1,and identified several novel genes with moderate mutation frequencies,including ARID1A,ARID2,MLL,MLL2,MLL3,MLL4,IRF2,ATM,CDKN2A,FGF19,PIK3CA,RPS6KA3,JAK1,KEAP1,NFE2L2,C16orf62,LEPR,RAC2,and IL6ST.Functional classification of these mutated genes suggested that alterations in pathways participating in chromatin remodeling,Wnt/β-catenin signaling,JAK/STAT signaling,and oxidative stress play critical roles in HCC tumorigenesis.Nevertheless,because there are few druggable genes used in HCC therapy,the identification of new therapeutic targets through integrated genomic approaches remains an important task.Because a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain,copy number alteration(CNA)analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons,homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC progression.Moreover,integration of CNAs with other high-throughput genomic data,such as aberrantly coding transcriptomes and non-coding gene expression in human HCC tissues and rodent HCC models,provides lines of evidence that can be used to facilitate the identification of novel HCC target genes with the potential of improving the survival of HCC patients. | De-Leung Gu Yen-Hsieh Chen Jou-Ho Shih Chi-Hung Lin Yuh-Shan Jou Chian-Feng Chen | 2013 | World Journal of Gastroenterology2013，19，47： | 6 |
| 4 | An Internal State Variable Model for the Low Temperature Tempering of Low Alloy Steels显示文摘An internal state variable (ISV) framework is used to predict the rate and degree of strain relaxation associated with the stage I, low temperature tempering of martensite. A single variable tracks the change in volume between the tempered an untempered structures. The rate at which this occurs is taken to be a function of martensite fraction, temperature, degree of tempering, and carbon concentration. Experimental dilatometty data is used to both fit and validate the model. | Mark T. Lusk, Young-Kook Lee, Herng-Jeng Jou, William H. Elliott, Gerard M Ludtka 1.Materials Science Program, Division of Engineering, Colorado School of Mines, Golden, CO. U.S. 80401 2.Questek Innovations LCC, 1801 Maple Avenue, Evanston, IL, U.S. 602 | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 5 |
| 5 | Temporary Drainage Clamping After Total Knee Arthroplasty显示文摘 | Ta-Wei Tai Chyun-Yu Yang I-Ming Jou Kuo-An Lai Chia-Hui Chen | 2010 | The Journal of Arthroplasty2010，，8： | 3 |
| 6 | RADAR OBSERVATION OF PRECIPITATION ASYMMETRIES IN TROPICAL CYCLONES MAKING LANDFALL ON EAST CHINA COAST显示文摘This study explores,for the first time,the asymmetric distribution of precipitation in tropical cyclones(TCs) making landfall along east China coast using reflectivity data collected from coastal Doppler radars at China's Mainland and Taiwan.Six TCs(Saomai,Khanun,Wipha,Matsa,Rananim and Krosa) from 2004 to 2007 are examined.The temporal and spatial evolution of these TCs’ inner and outer core asymmetric precipitation patterns before and after landfall is investigated.The radius of inner-core region is a function of the size of a TC apart from a fixed radius(100 km) adopted in previous studies.All six TCs possessed distinct asymmetric precipitation patterns between the inner-and outer-core regions.The amplitude of asymmetry decreases with the increasing TC intensity and it displays an ascending(descending) trend in the inner(outer) core.In the inner-core region,the heavy rainfall with reflectivity factor above 40 d BZ tends to locate at the downshear side before landfall.Four cases have precipitation maxima on the downshear left side,in agreement with previous studies.As TCs approaching land(~ 2 hr before landfall),their precipitation maxima generally shift to the front quadrant of the motion partly due to the interaction of TC with the land surface.In the outer-core region,the precipitation maxima occur in the front quadrant of the motion in five of the six cases before landfall.After landfall,the precipitation maxima shift from the right-front quadrant clockwisely to the right-rear quadrant of the motion collocated well with the mountainous areas along the coast,which indicates the impact of topography forcing on the precipitation distribution.This study illustrated how the precipitation asymmetry in the inner-and outer-core at different stages of TC landfall is affected by storm motion,vertical wind shear and topography. | DAN WU KUN ZHAO BEN JONG-DAO JOU WEN-CHAU LEE | 2013 | Tropical Cyclone Research and Review2013，2，2： | 3 |
| 7 | Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease显示文摘 | Janice Jou Steve Choi Anna Diehl | 2008 | Semin Liver Dis2008，，04： | 3 |
| 8 | Improving the Extreme Rainfall Forecast of Typhoon Morakot(2009) by Assimilating Radar Data from Taiwan Island and China's Mainland显示文摘This study examined the impact of an improved initial field through assimilating ground-based radar data from China's Mainland and Taiwan Island to simulate the long-lasting and extreme rainfall caused by Morakot(2009). The vortex location and the subsequent track analyzed through the radial velocity data assimilation(VDA) are generally consistent with the best track. The initial humidity within the radar detecting region and Morakot's northward translation speed can be significantly improved by the radar reflectivity data assimilation(ZDA). As a result, the heavy rainfall on both sides of Taiwan Strait can be reproduced with the joint application of VDA and ZDA. Based on sensitivity experiments, it was found that, without ZDA, the simulated storm underwent an unrealistic inward contraction after 12-h integration, due to underestimation of humidity in the global reanalysis, leading to underestimation of rainfall amount and coverage. Without the vortex relocation via VDA, the moister(drier) initial field with(without) ZDA will produce a more southward(northward) track, so that the rainfall location on both sides of Taiwan Strait will be affected. It was further found that the improvement in the humidity field of Morakot is mainly due to assimilation of high-value reflectivity(strong convection) observed by the radars in Taiwan Island, especially at Kenting station. By analysis of parcel trajectories and calculation of water vapor flux divergence, it was also found that the improved typhoon circulation through assimilating radar data can draw more water vapor from the environment during the subsequent simulation, eventually contributing to the extreme rainfall on both sides of Taiwan Strait. | Xuwei BAO Dan WU Xiaotu LEI Leiming MA Dongliang WANG Kun ZHAO Ben Jong-Dao JOU | 2017 | Journal of Meteorological Research2017，31，4： | 3 |
| 9 | Reactive oxygen species mediate Aβ(25-35)-induced activation of BV2 microglia显示文摘 | Kang J Park EJ Jou I Kim JH Joe EH | 2001 | Neuroreport2001，12，7： | 2 |
| 10 | Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma显示文摘 | Ma?té Lewin Najat Mourra Isabelle Honigman Jean-Fran?ois Fléjou Rolland Parc Lionel Arrivé Jean-Michel Tubiana | 2006 | European Radiology2006，，2： | 2 |
| 11 | Androgen Receptor Is a New Potential Therapeutic Target for the Treatment of Hepatocellular Carcinoma显示文摘 | Weng–Lung Ma Cheng–Lung Hsu Ming–Heng Wu Chun–Te Wu Cheng–Chia Wu Jiann–Jyh Lai Yuh–Shan Jou Chun–Wei Chen Shuyuan Yeh Chawnshang Chang | 2008 | Gastroenterology2008，，3： | 2 |
| 12 | Ultrasonography for Diagnosing Carpal Tunnel Syndrome: A Meta-Analysis of Diagnostic Test Accuracy显示文摘 | Ta-Wei Tai Cheng-Yi Wu Fong-Chin Su Tai-Chang Chern I-Ming Jou | 2012 | Ultrasound in Medicine & Biology2012，，7： | 2 |
| 13 | Csirhiuorrhoea; the plale of endoscopic sinus surgery显示文摘 | Marshall AH Jous NS Robertsou IJ | 2001 | Br J Neuro surg2001，15，： | 1 |
| 14 | Biocompatibility and antibacterial activity of chitosan and collagen immobilized poly(3-hydroxybutyric acid-co-3- hydroxyvaleric acid) 显示文摘 | Hu SG Jou CH Yang MC | 2004 | Carthohydrate Polymer2004，58，2： | 1 |
| 15 | Application of numerical simulation for wear analysis of warm forging显示文摘 | Lee R S Jou J L | 2003 | Journal of Materials Processing Technology2003，140，13： | 1 |
| 16 | Phase equilibria in the system n-butane-water-methyldiethanolamine 显示文摘 | Jou Fang-Yuan Carroll J J Mather A E | 1996 | Fluid Phase Equilibria1996，116，： | 1 |
| 17 | Flows in stenotic vessels 显示文摘 | Berger S A Jou L D | 2000 | Annual Review of Fluid Mechanics2000，32，： | 1 |
| 18 | Protein adsorption,fibroblast activity and antibacterial properties of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) grafted with chitosan and chitooligosaccharide after immobilized with hyaluronic acid显示文摘 | Hu SG Jou CH Yang MC | 2003 | Biomaterials2003，24，16： | 1 |
| 19 | Neural Correlates of the 'Aha' Experiences: Evidence from an fMRI Study of Insight Problem Solving 显示文摘 | QIU Jiang LI Hong JOU J | 2010 | Cortex2010，46，： | 1 |
| 20 | Percutaneous nephrolithotomy with holmium:Yttrium-aluminum-garnet laser and fiber guider-report of 349 cases显示文摘 | Jou YC Shen JH Cheng MC | 2005 | Urology2005，65，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员