|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | Expression of bone matrix protein during dexamethasone-induced mineralization of human bone marrow stromal cell显示文摘 | Cheng SL Zhang SF Avioli LV | 1996 | J Cell Biochem1996，61，2： | 2 |
| 4 | Long-chain SFA at the sn - 1, 3 positions of TAG reduce body fat deposition in C57BL/6 mice 显示文摘 | GoukSW Cheng SF MokJ SL etal | 2013 | British Journal of Nu- trition2013，110，11： | 1 |
| 5 | Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial -mesenchymal transformation显示文摘 | Cheng SF David HL | 2003 | Am J Pathol2003，162，12： | 1 |
| 6 | Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome显示文摘 | Ahmed SF Cheng A Dovey L | 2000 | J Clin Endocrinol Metab2000，85，2： | 1 |
| 7 | Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells显示文摘 | Cheng SL Zhang SF Avioli LV | 1996 | J Cell Biochem1996，61，2： | 1 |
| 8 | Using clinical caring journa ling: Nursing student and instructor experiences显示文摘 | Kuo CL Turton M Cheng SF | 2011 | J Nurs Res2011，19，2： | 1 |
| 9 | Development and preliminary testing of a self - rating instrument to measure self - directedlearning ability of nursing students显示文摘 | Cheng SF Kuo CL Lin KC | 2010 | Int J Nurs Stud2010，47，9： | 1 |
| 10 | Robust hepatitis C virus infection in vitro显示文摘 | Zhong J Gastaminza P Cheng G Kapadia S Kato T Burton DR Wieland SF Uprichard SL Wakita T Chisari FV | 2005 | Proc Natl Acad Sci USA2005，102，26： | 1 |
| 11 | Identification of differential- ly expressed genes induced by Bamboo mosaic virus infection in Nicotiana benthamiana by cDNA-amplified fragment length poly- morphism显示文摘 | Cheng SF Huang YP Wu ZR | 2010 | BMC Plant Biology2010，10，： | 1 |
| 12 | Occupational exposures of air- borne trichloramine at indoor swimming pools in Taipei 显示文摘 | Chu TS Cheng SF Wang GS | 2013 | Sci Total Environ2013，，： | 1 |
| 13 | Comeal neovascularization and the utility of topi-cal VEGF inhibition : ranibizumab (Lucentis) vs bevacizuma(Avastin) 显示文摘 | STEVENSON W CHENG SF DASTJERDI MH FERRARI G DANA R | 2012 | Ocul Surf2012，10，2： | 1 |
| 14 | Fat-suppressed three-dimen- sional fast spoiled gradient-recalled echo imaging: a modified FS 3D SPGR technique for assessment of patellofemoral joint chondromalacia显示文摘 | Wang SF Cheng HC Chang CY | 1999 | Clin Imaging1999，23，： | 1 |
| 15 | Dose-finding study for the use of long-acting gonadotrophin-releasing hormone ana- logues prior to ovarian stimulation for IVF显示文摘 | Yim SF Lok H Cheng LP | 2001 | Hum Reprod2001，16，： | 1 |
| 16 | Brain MR imagingin acute hyperammonemic encephalopathy arising from late-onsetornithine transcarbamylase deficiency 显示文摘 | Takanashi J Barkovich AJ Cheng SF | 2003 | AJNR Am JNeuroradiol2003，24，3： | 1 |
| 17 | Topical ranibizumab as atreatment of corneal neovascularization 显示文摘 | FERRARI G DASTJERDI MH OKANOBO A CHENG SF AMPARO F NALLASAMY N | 2013 | Cornea2013，32，7： | 1 |
| 18 | Glucose-6-phosphate dehydrogenase deficiency enhances enterovirus 71 infection显示文摘 | Ho HY Cheng ML Weng SF | 2008 | J Gen Virol2008，89，9： | 1 |
| 19 | Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells显示文摘 | Cheng SL Zhang SF Avioli LV | 1996 | J Cell Biochem1996，61，2： | 1 |
| 20 | Cyclin D1 overexpression and poor clinical outcomes in Taiwm~ese oral cavity squamous cellcarcinoma显示文摘 | Huang SF Cheng SD Chuang WY | 2012 | World J Surg Onco12012，10，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员