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| 1 | Mapping the permafrost stability on the Tibetan Plateau for 2005–2015显示文摘Data scarcity is a major obstacle for high-resolution mapping of permafrost on the Tibetan Plateau(TP).This study produces a new permafrost stability distribution map for the 2010 s(2005–2015)derived from the predicted mean annual ground temperature(MAGT)at a depth of zero annual amplitude(10–25 m)by integrating remotely sensed freezing degree-days and thawing degree-days,snow cover days,leaf area index,soil bulk density,high-accuracy soil moisture data,and in situ MAGT measurements from 237 boreholes on the TP by using an ensemble learning method that employs a support vector regression model based on distance-blocked resampled training data with 200 repetitions.Validation of the new permafrost map indicates that it is probably the most accurate of all currently available maps.This map shows that the total area of permafrost on the TP,excluding glaciers and lakes,is approximately 115.02(105.47–129.59)×10^4 km^2.The areas corresponding to the very stable,stable,semi-stable,transitional,and unstable types are 0.86×10^4,9.62×10^4,38.45×10^4,42.29×10^4,and 23.80×10^4 km^2,respectively.This new map is of fundamental importance for engineering planning and design,ecosystem management,and evaluation of the permafrost change in the future on the TP as a baseline. | Youhua RAN Xin LI Guodong CHENG Zhuotong NAN Jinxing CHE Yu SHENG Qingbai WU Huijun JIN Dongliang LUO Zhiguang TANG Xiaobo WU | 2021 | Science China Earth Sciences2021，64，1： | 11 |
| 2 | Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration显示文摘 | SHI Yu-long MIAO Rui-zheng CHENG Li GUO Xiao-bo YANG Bo JING Chang-qing ZHANG Li JINXing LI Le-ping | 2013 | Chinese Medical Journal2013，，4： | 11 |
| 3 | MXene-coated silk-derived carbon cloth toward flexible electrode for supercapacitor application显示文摘Flexible supercapacitors are promising energy storage devices in wearable smart electronics. Exploring cost-efficient electrodes with high capacitance would promote the wide-scale application of such capacitors. Herein, in order to explore a methodology for preparing low cost, flexible, tough, and up-scalable supercapacitor electrodes, silk textile is directly carbonized to make a conductive free-standing textile substrate. Through mildly baking the surfactant-free Ti_3C_2T_x flakes suspension loaded on the carbonized silk cloth, a uniform and adhesive coating consisting of nanometer-thick Ti_3C_2T_x flakes is well established on the conductive fabric support, forming a MXene-coated flexible textile electrode. The fabricated electrode exhibits a high areal capacitance of 362 m F/cm^2 with excellent cyclability and flexibility. Moreover,capacitance changes neglegibly under the bending deformation mode. This study elucidates the feasibility of using silk-derived carbon cloth from biomss for MXene-based flexible supercapacitor. | Minmin Hu Tao Hu Renfei Cheng Jinxing Yang Cong Cui Chao Zhang Xiaohui Wang | 2018 | Journal of Energy Chemistry2018，27，1： | 10 |
| 4 | Radio Channel Measurements and Analysis at 2.4/5GHz in Subway Tunnels显示文摘There is an increasing demand on wireless communications in subway tunnels to provide video surveillance and sensory data for security,maintenance and train control,and to offer various communication or entertainment services(e.g.,Internet,etc.) to passengers as well.The wireless channel in tunnels is quite unique due to the confined space and the waveguide effects.Therefore,modeling the radio channel characteristics in tunnels is critically important for communication systems design or optimization.This paper investigates the key radio channel characteristics of a subway tunnel at 2.4 GHz and 5 GHz,such as the path loss,root mean square(RMS) delay spread,channel stationarity,Doppler shift,and channel capacity.The field measurements show that channel characteristics in tunnels are highly location-dependent and there exist abundant components in Doppler shift domain.In the straight section of the subway tunnel,the measured path loss exponents are close to1.6,lower than that in free space. | LI Jinxing ZHAO Youping ZHANG Jing JIANG Rui TAO Cheng TAN Zhenhui | 2015 | China Communications2015，12，1： | 9 |
| 5 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 6 | Observation of unconventional anomalous Hall effect in epitaxial CrTe thin films显示文摘 | Dapeng Zhao Liguo Zhang Iftikhar Ahmed Malik Menghan Liao Wenqiang Cui Xinqiang Cai Cheng Zheng Luxin Li Xiaopeng Hu Ding Zhang Jinxing Zhang Xi Chen Wanjun Jiang Qikun Xue | 2018 | Nano Research2018，11，6： | 3 |
| 7 | The Brassica napus GATA transcription factor BnA5.ZML1 is a stigma compatibility factor显示文摘Self-incompatibility(SI)is a genetic mechanism that rejects self-pollen and thus prevents inbreeding in some hermaphroditic angiosperms.In the Brassicaceae,SI involves a pollen-stigma recognition system controlled by a single locus known as the S locus,which consists of two highly polymorphic genes that encode S-locus cysteine-rich protein(SCR)and S-receptor kinase(SRK).When self-pollen lands on the stigma,the S-haplotype-specific interaction between SCR and SRK triggers SI.Here,we show that the GATA transcription factor BnA5.ZML1 suppresses SI responses in Brassica napus and is induced after compatible pollination.The loss-of-function mutant bna5.zml1 displays reduced self-compatibility.In contrast,overexpression of BnA5.ZML1 in self-incompatible stigmas leads to a partial breakdown of SI responses,suggesting that BnA5.ZML1 is a stigmatic compatibility factor.Furthermore,the expression levels of SRK and ARC1 are up-regulated in bna5.zml1 mutants,and they are down-regulated in BnA5.ZML1 overexpressing lines.SRK affects the cellular localization of BnA5.ZML1 through direct protein–protein interaction.Overall,our findings highlight the fundamental role of BnA5.ZML1 in SI responses in B.napus,establishing a direct interaction between BnA5.ZML1 and SRK in this process. | Zhiqiang Duan Yatao Zhang Jinxing Tu Jinxiong Shen Bin Yi Tingdong Fu Cheng Dai Chaozhi Ma | 2020 | Journal of Integrative Plant Biology2020，62，8： | 2 |
| 8 | Mapping of BnMs4 and BnRf to a common microsyntenic region of Arabidopsis thaliana chromosome 3 using intron polymorphism markers显示文摘 | Shengqian Xia Ling Cheng Feng Zu Xiaoling Dun Zhengfu Zhou Bin Yi Jing Wen Chaozhi Ma Jinxiong Shen Jinxing Tu Tingdong Fu | 2012 | Theoretical and Applied Genetics2012，，7： | 1 |
| 9 | Satellite-based detection of 16.76 MeV γ-ray from H-bomb D-T fusion显示文摘Based on the high energy γ-ray yield from the H-bomb D-T fusion reaction, it brings forward the idea applying the 16.76 MeV γ-ray to judge whether the H-bomb happens or not, and to deduce the explosion TNT equivalent accurately. The Monte Carlo N-Particle was applied to simulate the high energy γ-ray radiation characteristics reaching the geosynchronous orbit satellite, and the CVD diamond detector suit for the requirements was researched. A series of experiments were carried out to testify the capabilities of the diamond detector. It provides a brand-new approach to satellite-based nuclear explosion detection. | CHENG Jinxing WANG Lan OUYANG Xiaoping SHI Jianfang ZHANG Anhui SHEN Chunxia OUYANG Maojie NAN Qinliang | 2008 | Nuclear Science and Techniques2008，19，1： | 0 |
| 10 | Directed evolution of a neutrophilic and mesophilic methanol dehydrogenase based on high-throughput and accurate measurement of formaldehyde显示文摘Methanol is a promising one-carbon feedstock for biomanufacturing,which can be sustainably produced from carbon dioxide and natural gas.However,the efficiency of methanol bioconversion is limited by the poor catalytic properties of nicotinamide adenine dinucleotide(NAD^(+))-dependent methanol dehydrogenase(Mdh)that oxidizes methanol to formaldehyde.Herein,the neutrophilic and mesophilic NAD^(+)-dependent Mdh from Bacillus stearothermophilus DSM 2334(Mdh_(Bs))was subjected to directed evolution for enhancing the catalytic activity.The combination of formaldehyde biosensor and Nash assay allowed high-throughput and accurate measurement of formaldehyde and facilitated efficient selection of desired variants.Mdh_(Bs)variants with up to 6.5-fold higher K_(cat)/K_(M)value for methanol were screened from random mutation libraries.The T153 residue that is spatially proximal to the substrate binding pocket has significant influence on enzyme activity.The beneficial T153P mutation changes the interaction network of this residue and breaks theα-helix important for substrate binding into two shortα-helices.Reconstructing the interaction network of T153 with surrounding residues may represent a promising strategy to further improve Mdh_(Bs),and this study provides an efficient strategy for directed evolution of Mdh. | Jin Qian Liwen Fan Jinxing Yang Jinhui Feng Ning Gao Guimin Cheng Wei Pu Wenjuan Zhou Tao Cai Shuang Li Ping Zheng Jibin Sun Depei Wang Yu Wang | 2023 | Synthetic and Systems Biotechnology2023，8，3： | 0 |
| 11 | Comparative phosphoproteomic analysis of compatible and incompatible pollination in Brassica napus L.显示文摘Self-incompatibility(SI)promotes outbreeding and prevents self-fertilization to promote genetic diversity in angiosperms.Several studies have been carried to investigate SI signaling in plants;however,protein phosphorylation and dephosphorylation in the fine-tuning of the SI response remain insufficiently understood.Here,we performed a phosphoproteomic analysis to identify the phosphoproteins in the stigma of self-compatible‘Westar’and self-incompatible‘W-3’Brassica napus lines.A total of 4109 phosphopeptides representing 1978 unique protein groups were identified.Moreover,405 and 248 phosphoproteins were significantly changed in response to SI and self-compatibility,respectively.Casein kinaseⅡ(CKⅡ)phosphorylation motifs were enriched in self-incompatible response and identified 127 times in 827 dominant SI phosphorylation residues.Functional annotation of the identified phosphoproteins revealed the major roles of these phosphoproteins in plant-pathogen interactions,cell wall modification,mRNA surveillance,RNA degradation,and plant hormone signal transduction.In particular,levels of homolog proteins ABF3,BKI1,BZR2/BSE1,and EIN2 were significantly increased in pistils pollinated with incompatible pollens.Abscisic acid and ethephon treatment partially inhibited seed set,while brassinolide promoted pollen germination and tube growth in SI response.Collectively,our results provided an overview of protein phosphorylation during compatible/incompatible pollination,which may be a potential component of B.napus SI responses. | Zhiqiang Duan Shengwei Dou Zhiquan Liu Bing Li Bin Yi Jinxiong Shen Jinxing Tu Tingdong Fu Cheng Dai Chaozhi Ma | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 0 |
| 12 | A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate显示文摘Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃ in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity. | Liming Cao Maolin Sun Chaoming Liang Lei Yang Yueyue Ma Ruihua Cheng Yanxiong Ke Wei Yu Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 13 | Corrigendum to“MXene-coated silk-derived carbon cloth toward flexible electrode for supercapacitor application”[J.Energy.Chem.27(2018)161–166]显示文摘The authors regret that the printed version of the above article contained some errors.(1)The SEM images of CSC and CSC@Ti3C2Tx electrode in Fig.1 are corrected to reflect the originality of the images. | Minmin Hu Tao Hua Renfei Cheng Jinxing Yang Cong Cui Chao Zhang Xiaohui Wang | 2022 | Journal of Energy Chemistry2022，31，8： | 0 |
| 14 | Functional genomics of Brassica napus:Progresses,challenges,and perspectives显示文摘Brassica napus,commonly known as rapeseed or canola,is a major oil crop contributing over 13%to the stable supply of edible vegetable oil worldwide.Identification and understanding the gene functions in the B.napus genome is crucial for genomic breeding.A group of genes controlling agronomic traits have been successfully cloned through functional genomics studies in B.napus.In this review,we present an overview of the progress made in the functional genomics of B.napus,including the availability of germplasm resources,omics databases and cloned functional genes.Based on the current progress,we also highlight the main challenges and perspectives in this field.The advances in the functional genomics of B.napus contribute to a better understanding of the genetic basis underlying the complex agronomic traits in B.napus and will expedite the breeding of high quality,high resistance and high yield in B.napus varieties. | Zengdong Tan Xu Han Cheng Dai Shaoping Lu Hanzi He Xuan Yao Peng Chen Chao Yang Lun Zhao Qing-Yong Yang Jun Zou Jing Wen Dengfeng Hong Chao Liu Xianhong Ge Chuchuan Fan Bing Yi Chunyu Zhang Chaozhi Ma Kede Liu Jinxiong Shen Jinxing Tu Guangsheng Yang Tingdong Fu Liang Guo Hu Zhao | 2024 | Journal of Integrative Plant Biology2024，66，3： | 0 |
| 15 | Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor显示文摘A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS production.We constructed a telescoped two-step continuous flow platform.This involved a continuous tanshinone IIA sulfonation and in-line salt formation.For the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser micromachining.Compared to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal conditions.The proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production. | Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 16 | Genome-wide identification and expression profiling of the YUCCA gene family in Brassica napus显示文摘Auxin is essential for plant growth and development,also closely related to plant architecture.YUCCA(YUC)proteins catalyse the rate-limiting step for endogenous auxin biosynthesis.In this study,we identified 57 Bn YUC genes in Brassica napus(rapeseed)genome,located on 17 chromosomes.Among them,A09 chromosome contained the most Bn YUCs as 6.Phylogenetic tree showed that all Bn YUC members were divided into 2 evolutionary clusters,including 7 sub-groups.Among the sub-groups,Clade I-C consisted 20 members,evolved independently from Arabidopsis thaliana,and motif 10 was unique.Genomic collinearity analysis showed that YUC collinear gene pairs widely existed in Brassica species,indicating that this family has a high retention rate in the evolution.Expression profile suggested that the Bn YUC family genes tended to express in specific growth/development stages as well as suffering stress/hormone treatments.It suggested that dominant expression of specific members existed with each development stage or treatment,indicating that each Bn YUC might have a clear division of work,and play a given biological function.This work was expected to build a basis for further study of the involvement of Bn YUC in growth,development and stress response. | Ka Zhang Jinfang Zhang Cheng Cui Liang Chai Benchuan Zheng Jun Jiang Haojie Li Jinxing Tu | 2022 | Oil Crop Science2022，7，3： | 0 |
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