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| 1 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 2 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 3 | The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist显示文摘 | Laffey JG Boylan JF Cheng DC | 2002 | Anesthesiology2002，97，1： | 1 |
| 4 | lntraoperative awareness in fast-track cardiac anesghesia显示文摘 | Down NP Cheng DC Karshi JM | 1998 | Anesthesiology1998，89，5： | 1 |
| 5 | Hypertonie marmitol loading of NF- kappaB transcription factor decoys in human brain microvascular endothelial cells blocks upregulation of ICAM - 1 显示文摘 | Hess DC Howard E Cheng C | 2000 | Stroke2000，31，5： | 1 |
| 6 | Hypertonic Mannitol Loading of NF-kB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks Upregulation of ICAM-1显示文摘 | Hess DC Howard E Cheng C | 2005 | Stroke(S0039-2499)2005，31，5： | 1 |
| 7 | Akt fine-tunes NF-κB-dependent gene expression during T cell activation显示文摘 | Cheng J Phong B Wilson DC | 2011 | J Biol Chem2011，286，36： | 1 |
| 8 | Does off-pump coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with conventional coronary artery bypass? A meta-analysis of randomized trials显示文摘 | Cheng DC Bainbridge D Martin JE | 2005 | Anesthesiology2005，102，1： | 1 |
| 9 | Does off-pump coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with conventional cot onary artery bypass? a meta-analysis of randomized trials 显示文摘 | Cheng DC Bainbridge D Martin JE | 2005 | Anesthesiology2005，102，1： | 1 |
| 10 | Pharmacokinetics of tranexamic acid during cardiopulmo- nary bypass显示文摘 | Dowd NP Karski JM Cheng DC | 2002 | Anesthesiology2002，97，2： | 1 |
| 11 | Potential for soil carbonsequestration of eroded areas in subtropical china显示文摘 | Shi XZ Wang H J Yu DS Weindorf DC Cheng XF Pan XZ Sun WX Chen JM | 2009 | Soil and Tillage Research2009，105，： | 1 |
| 12 | Different iation-dependent up-regulation of the human papilloma-virus E7 gene reactiva tes cellular DNA replication in suprabasal differentiated keratinocytes显示文摘 | Cheng S Schmidt-Grimminger DC Murant T | 1995 | Genes Dev1995，9，： | 1 |
| 13 | Influence of meteorological conditions and particulate matter on visual range impairment in Jinan, China显示文摘 | Yang LX Wang DC Cheng SH | 2007 | Sci Total Environ2007，383，： | 1 |
| 14 | Hypertonic mannitol loading of NF-kappaB transcription factor decoys in human brain microvascular endothelial cells blocks upregulation of ICAM-1 显示文摘 | Howard E Cheng C Carroll J Hill WD | 2000 | Stroke2000，31，5： | 1 |
| 15 | Clinical evaluation of C7 spinal nerve transection: 21 patients with at least 2 years' follow-up显示文摘 | Chuang DC Cheng SL Wei FC | 1998 | Br J Plast Surg1998，51，4： | 1 |
| 16 | Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans 显示文摘 | Greiwe JS Cheng B Rubin DC | 2001 | FASEB J2001，15，2： | 1 |
| 17 | Quantification of mieroheterogeneity in glioblastoma muhiforme with high-resolution magie-angle spin ning (HRM_AS) proton magnetie resonance spectroscopy 显示文摘 | Cheng LL Anthony DC Comite AR etal | 2000 | Neuro-oneol2000，2，2： | 1 |
| 18 | Pharmacokinetics of tranexamic acid during cardiopulmonary bypass显示文摘 | Dowd NP Karski JM Cheng DC | | 0，，02： | 1 |
| 19 | Quantification of micro - heterogeneity in gliobl astomamulti forme with ex vlvo high - resolution magic-angle spinning(HRMAS) proton magnetic resonance speetroscopy显示文摘 | Cheng LL Anthony DC Comite AR | 2000 | Neuro Oncol2000，2，： | 1 |
| 20 | Pharmaeokinetics of tranexamic acid during eardiopulmonary bypass 显示文摘 | Dowd NP Karski JM Cheng DC | 2002 | Anesthesiology2002，97，2： | 1 |
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