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| 1 | Levels of insecticide resistance to deltamethrin,malathion,and temephos,and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands(French West Indies)显示文摘Background:In the Guadeloupe and Saint Martin islands,Aedes aegypti mosquitoes are the only recognized vectors of dengue,chikungunya,and Zika viruses.For around 40 years,malathion was used as a mosquito adulticide and temephos as a larvicide.Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century,deltamethrin and Bacillus thuringiensis var.israelensis are the remaining adulticide and larvicide,respectively,used in Guadeloupe.In order to improve the management of vector control activities in Guadeloupe and Saint Martin,we investigated Ae.aegypti resistance to and mechanisms associated with deltamethrin,malathion,and temephos.Methods:Ae.aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin.Larvae were used for malathion and temephos bioassays,and adult mosquitoes for deltamethrin bioassays,following World Health Organization recommendations.Knockdown resistance(Kdr)genotyping for V1016I and F1534C mutations,and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain.Results:Resistance ratios(RR50)calculated for Ae.aegypti larvae showed high resistance levels to temephos(from 8.9 to 33.1-fold)and low resistance levels to malathion(from 1.7 to 4.4-fold).Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50%of individuals,varying from 8.0 to 28.1-fold.Molecular investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C(from 85 to 96%and from 90 to 98%,respectively),as well as an overexpression of the glutathione S-transferase gene,GSTe2,the carboxylesterase CCEae3a,and the cytochrome genes 014614,CYP6BB2,CYP6M11,and CYP9J23.Conclusions:Ae.aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates(temephos and malathion),and pyrethroids(deltamethrin).The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations,and an over-expression of CCEae3a,GSTe2,and four cytochrome P450 genes(014614,CYP9J23,CYP6M11,CYP6BB2).These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae.aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin. | Daniella Goindin Christelle Delannay Andric Gelasse Cedric Ramdini Thierry Gaude Frederic Faucon Jean-Philippe David Joël Gustave Anubis Vega-Rua Florence Fouque | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 2 | Variable structure tracking control of a single-link flexible arm using time-varying sliding surface 显示文摘 | Eric H K F Cedric K M L | 1999 | J of Robotic Systems1999，16，12： | 2 |
| 3 | Thin-Pavement thickness estimation using GPR with high-resolution and superresolu- tion methods 显示文摘 | Cedric L B Vincent B Wang Y | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，8： | 1 |
| 4 | Large-scale Indexing of Spatial Data in Distributed Repositories:the SD-Rtree显示文摘 | Cedric M Witold L Philippe R | | 0，，： | 1 |
| 5 | Modified ESPRIT( M-ES- PRIT) algorithm for time delay estimation in both any noise and any radar pulse context by a GPR radar 显示文摘 | Cedric L B Vincent B Wang Y D | 2009 | Signal Processing2009，90，1： | 1 |
| 6 | Design and Development of a Flexible Strain Sensor for Textile Structures Based on a Conductive Polymer Composite 显示文摘 | Cedric C Vladan K Maryline L | 2007 | Sensors2007，，7： | 1 |
| 7 | CVD and CVI of pyrocarbon from various precursors 显示文摘 | Gerard L Vignoles Francis Langlais Cedric Descamps | 2004 | Surface & Coatings Technology2004，，： | 1 |
| 8 | Medial prefrontal cortex and the self inmajor depression 显示文摘 | Cedric L Pauline D | 2012 | Journal of Affective Disorders2012，136，： | 1 |
| 9 | Synergetic activity of eat-chin and other antioxidants 显示文摘 | Cedric T S Andrew L W | 1999 | J Agric Food Chem1999，47，11： | 1 |
| 10 | Synergetic activity of catechin and other antioxidant显示文摘 | Cedric T Andrew L | 1999 | J Agric Food Chem1999，47，： | 1 |
| 11 | CVD and CVI of pyrocarbon from various precursors 显示文摘 | GERARD LV FRANCIS L CEDRIC D | 2004 | Surf Coat Technol2004，，： | 1 |
| 12 | Fluorescence probing investigation of the mechanism of formation of MSU-type mesoporous silica prepared in fluoride medium显示文摘 | CEDRIC L BENEDICTE L CLAIRE M | 2005 | Langmuir2005，21，19： | 1 |
| 13 | An assessment of rnnoff trends inundisturbed catchments in the Celtic regions of North West Europe 显示文摘 | Hannaford Jamie Laize Cedric L R Marsh Terry J | 2007 | IAHS--AISH Publication2007，310，： | 1 |
| 14 | Characterization of fluidization quality in fludized beds of wetparticles 显示文摘 | Steven L M Mohammad S Cedric B Franco B Edward W C | 2004 | International Journal of Chemical Reactor Engineering2004，2，1： | 1 |
| 15 | Trophic ecology in aNorthern Brittany (Batz Island, France) kelp {Lami-naria digitata) forest, as investigated through stableisotopes and chemical assays显示文摘 | Gauthier S Pascal R Cedric L | 2010 | Journal of Sea Re-search2010，63，1： | 1 |
| 16 | Support vector machine for multifrequency SAR polarimetric data classification显示文摘 | CEDRIC L FRISON P L CELINE T | 2009 | IEEE Transactions on Geoscience and Remote Sensing2009，47，12： | 1 |
| 17 | A double step synthesis of mesoporous micrometric spherical MSU-X silica particles显示文摘 | Cedric B Arie V D L Abdeslam E M etal | 1999 | Chem Commun1999，20，： | 1 |
| 18 | Controlled design of size-tunable monodisperse nickel nanoparticles显示文摘 | SOPHIE C CEDRIC B LIONEL N CLEMENT S PASCAL L F NICOLAS M | 2010 | Chem Mater2010，22，4： | 1 |
| 19 | Mutations in MAP3K1 Cause 46, XY Disorders of Sex Development and Implicate a Common Signal Transduction Pathway in Human Testis Determination显示文摘 | Alexander P Johnny L Cedric L C | 2010 | The American Journal of Human Genetics2010，87，： | 1 |
| 20 | Synergetic activity of catechin and other antioxidants显示文摘 | CEDRIC T S ANDREW L W | 1999 | J Agric Food Chem1999，47，11： | 1 |
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