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| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | The CSIRO automatic tester for length and strength 显示文摘 | Tompson R L Andrews M W Baumann A B | 1988 | J Text Inst1988，，79： | 2 |
| 4 | Population Incidence of Guillain-Barre Syndrome: A Systematic Review and Meta-Analysis显示文摘 | Sejvar James J Baughman Andrew L Wise Matthew Morgan Oliver W | 2011 | EN2011，，2： | 2 |
| 5 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 6 | A study of the products of the reaction of phosphorus and dioxygen显示文摘 | Bauschlicher C W Jr Zhou M Andrews L | | 0，，： | 1 |
| 7 | An Octahedral Template Based on a New Molecular Turn:Synthesis and Structure of a Model Complex and a Reactive,Diphenolic Ligand and Its Metal Complexes显示文摘 | Andrew L V Nathaniel W A Joseph A H | 1998 | Inorg Chem1998，37，： | 1 |
| 8 | The influence of cracks, notches and holes on the tensile strength of cellular solids 显示文摘 | Andrews E W Gibson L J | 2001 | Acta Materialia2001，49，： | 1 |
| 9 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 10 | Voluntary Disclosure of Segment Information 显示文摘 | Mitchell Jason D Chia Chris W L Loh Andrew S | 1995 | Accounting and Fi nance1995，35，： | 1 |
| 11 | Compressive and tensile behavior of aluminum foams显示文摘 | ANDREWS E SANDERS W GIBSON L J | 1999 | Materials Science and Engineering1999，14，5： | 1 |
| 12 | Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo 显示文摘 | Andrew B L Karen YO C Suramya W Thomas A M Bernard T G Stephen M R | 1998 | Chemical Research in Toxicology1998，11，4： | 1 |
| 13 | Partial coherence of a Gaussian beam wave in weak and strong optical turbulence 显示文摘 | Andrews L C Miller W B Ricklin J C | 1994 | J Opt Soc Am A1994，11，5： | 1 |
| 14 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 15 | Materials Science and Engineering A显示文摘 | Andrews E Sanders W Gibson L J | 1999 | 270:1131999，270，： | 1 |
| 16 | Finite element forming simulation for non- crimp fabrics using a non- orthogonal constitutive equation 显示文摘 | Yu W R Philip H Andrew L | 2005 | Composites Part A2005，36，8： | 1 |
| 17 | Expanding the potentialfor waste polyvinyl alcohol 显示文摘 | ANDREW J H VITALY L B SIMON W B | 2009 | Green Chemistry2009，11，： | 1 |
| 18 | Carbohydrate levels in field-grown leafy and normal maize genotypes显示文摘 | Dwyer L M Andrews C J Stewart D W | 1995 | Crop Sci1995，35，4： | 1 |
| 19 | A corn parison of rating scales for the alcohol-withdrawal syndrome 显示文摘 | David W Julia L Andrew McB | 2001 | Alcoho Alcoholism2001，36，2： | 1 |
| 20 | Chlorine-36in groundwater as a palaeoclimatic indicator:The East Midlands Triassic sandstone aquifer(UK)显示文摘 | Andrews J N Edmunds W M Smedley P L | 1994 | Earth and Planetary Science Letters1994，122，12： | 1 |
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