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| 1 | Proton pump inhibitors in cirrhosis:Tradition or evidence based practice?显示文摘Proton Pump Inhibitors (PPI) are very effective in inhibiting acid secretion and are extensively used in many acid related diseases. They are also often used in patients with cirrhosis sometimes in the absence of a specific acid related disease, with the aim of preventing peptic complications in patients with variceal or hypertensive gastropathic bleeding receiving multidrug treatment. Contradicting reports support their use in cirrhosis and evidence of their efficacy in this condition is poor. Moreover there are convincing papers suggesting that acid secretion is reduced in patients with liver cirrhosis. With regard to Helicobacter pylori (H pylori) infection, its prevalence in patients with cirrhosis is largely variable among different studies, and it seems that H pylori eradication does not prevent gastro-duodenal ulcer formation and bleeding. With regard to the prevention and treatment of oesophageal complications after banding or sclerotherapy of oesophageal varices, there is little evidence for a protective role of PPI. Moreover, due to liver metabolism of PPI, the dose of most available PPIs should be reduced in cirrhotics. In conclusion, the use of this class of drugs seems more habit related than evidence- based eventually leading to an increase in health costs. | Francesca Lodato Francesco Azzaroli Maria Di Girolamo Valentina Feletti Paolo Cecinato Andrea Lisotti Davide Festi Enrico Roda Giuseppe Mazzella | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 2 | ESWL for difficult bile duct stones:A 15-year single centre experience显示文摘AIM:To evaluate the efficacy of extracorporeal shock wave lithotripsy(ESWL)for the management of refractory bile duct cholelithiasis in a third level referral centre.METHODS:The clinical records of all patients treated with a second generation electromagnetic lithotripter (Lithostar Plus,SIEMENS)from October 1990 to April 2005 were evaluated.All patients were monitored during the procedure and antibiotics were administered in case of cholangitis.Theχ 2 test and logistic regression analysis were performed as appropriate.RESULTS:Two hundred and fourteen patients(102 males,112 females;mean age 74.8±0.84 years-single stone 97,multiple stones 117)underwent ESWL.The mean number of sessions and shock waves were 3.5 ±0.13 and 3477.06±66.17,respectively.The maximum stone size was 5 cm.Complete stone clearance was achieved in 192(89.7%)patients.Of the remain-ing patients 15 required surgery,2 a palliative stent and in 5 patients stone fragmentation led to effective bile drainage with clinical resolution despite incomplete clearance.Age,sex and stone characteristics were not related to treatment outcome.Major complications occurred in two patients(haemobilia and rectal bleeding) and minor complications in 25(3 vomiting,22 arrhythmias).No procedure-related deaths occurred.CONCLUSION:ESWL is a safe and effective technique for clearance of refractory bile duct stones. | Rosangela Muratori Francesco Azzaroli Federica Buonfiglioli Flavio Alessandrelli Paolo Cecinato Giuseppe Mazzella Enrico Roda | 2010 | World Journal of Gastroenterology2010，16，33： | 8 |
| 3 | Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis显示文摘 | Andrea Lisotti Francesco Azzaroli Federica Buonfiglioli Marco Montagnani Paolo Cecinato Laura Turco Claudio Calvanese Patrizia Simoni Massimo Guardigli Rosario Arena Alessandro Cucchetti Antonio Colecchia Davide Festi Rita Golfieri Giuseppe Mazzella | 2014 | Hepatology2014，，2： | 2 |
| 4 | Severe immune thrombocytopenia after peg-interferonalpha2a, ribavirin and telaprevir treatment completion: a case report and systematic review of literature显示文摘Mild to moderate autoimmune thrombocytopenia(AITP) is a common finding in patients receiving interferonbased antiviral treatment, due to bone marrow suppression. Here we report the case of a patient with chronic genotype 1b hepatitis C virus(HCV) infection treated with pegylated-interferon alpha-2a, ribavirin and telaprevir for 24 wk; the patient developed severe AITP three weeks after treatment withdrawal. We performed a systematic literature search in order to review all published cases of AITP related to HCV antiviral treatment. To our knowledge, this is the second case of AITP observed after antiviral treatment withdrawal. In most published cases AITP occurred during treatment; in fact, among 24 cases of AITP related to interferonbased antiviral treatment, only one occurred after discontinuation. Early diagnosis of AITP is a key factor in order to achieve an early interferon discontinuation; in the era of new direct antiviral agents those patients have to be considered for interferon-free treatment regimens. Prompt prescription of immuno-suppressant treatment(i.e., corticosteroids, immunoglobulin infusion and even rituximab for unresponsive cases) leads to favourable prognosis in most of cases. Physicians using interferonbased treatments should be aware that AITP can occur both during and after treatment, specially in the new era of interferon-free antiviral treatment. Finally, in the case of suspected AITP, presence of anti-platelet antibodies should be checked not only during treatment but alsoafter discontinuation. | Rosario Arena Paolo Cecinato Andrea Lisotti Federica Buonfiglioli Claudio Calvanese Giuseppe Grande Marco Montagnani Francesco Azzaroli Giuseppe Mazzella | 2015 | World Journal of Hepatology2015，7，12： | 2 |
| 5 | Influence of environmental factors and air composition on the emission of alpha-pinene from Quercus ilex leaves显示文摘 | LORETO F CICCIOLI P CECINATO A | 1996 | Plant Physiology1996，110，1： | 1 |
| 6 | Sources and photodecomposition of formaldehyde and acetaldehyde in Rome ambient air 显示文摘 | Possanzini M Di Palo V Cecinato A | 2002 | Atmos Environ2002，36，19： | 1 |
| 7 | Sources and photodecomposition of formaldehyde and acetaldehyde in Rome ambient air 显示文摘 | Possanzini M Palo D Cecinato A | 2002 | Atmospheric Environment2002，36，19： | 1 |
| 8 | Particulate n-alkanes, n-alkanoic acids and polycyclic aromatic hydrocarbons in the atmosphere of Algiers City Area 显示文摘 | Yassaa N Meklati B Y Cecinato A | 2001 | Atmos Environ2001，35，10： | 1 |
| 9 | Management of Radiation-Induced Rectal Bleeding显示文摘 | Liboria Laterza Paolo Cecinato Alessandra Guido Alessandro Mussetto Lorenzo Fuccio | 2013 | Current Gastroenterology Reports2013，，11： | 1 |
| 10 | Particulate n-alkanes, n-alkanoic acids and polycyclic aromatic hydrocarbons in the atmosphere of Algiers City Area显示文摘 | Yassaa N Meklatib Y Cecinato A | 2001 | Atmospheric Environment2001，35，： | 1 |
| 11 | Extracorporeal shock wave lithotripsy for difficult common bile duct stones: a comparison between 2 different lithotripters in a large cohort of patients显示文摘 | Cecinato P Fuceio L Azzaroli F | 2015 | Gastrointest Endosc2015，81，2： | 1 |
| 12 | Particulate n alkanes, n-alkanoic acids and polycyclic aromatic hydrocarbons in the atmosphere of Algiers city area显示文摘 | YASSAA N MEKLATI B Y CECINATO A | 2001 | Atmospheric Environment2001，35，： | 1 |
| 13 | Sources and photodecomposition of formaldehyde and acetaldehyde in Rome ambient air显示文摘 | POSSANZINI M PALO V D CECINATO A | 2002 | Atmos Environ2002，36，19： | 1 |
| 14 | Nitro - PAH in ambient particu- late matter in the atmosphere of Athens 显示文摘 | Marino F Cecinato A Siskos P | 2000 | Chemosphere2000，40，： | 1 |
| 15 | Particulate n-alkanes, n-alkanoic acids and polycyclic aromatic hydrocarbons in the atmosphere of Algiers city area 显示文摘 | YASSAA N MEKLATI B Y CECINATO A | 2001 | Atmospheric Environment2001，35，10： | 1 |
| 16 | Particulate n-alkanoic acids and polycyclic aromatic hydrocarbons in the atmosphere of algiers city area显示文摘 | YASSAA N MEKLATI B Y CECINATO A MARINO F | 2001 | Atmos Environ2001，35，10： | 1 |
| 17 | Formation and transport of 2-nitrofluoranthene and 2-nitrpyrene photochemical origin in the troposphere显示文摘 | CICCIOLI P CECINATO A BRACALEONI E | | 0，，14： | 1 |
| 18 | Particulate n-alkanes, n-alkanoie acids and polycyclic aromatic hydrocarbons in the atmosphere of Algiers City area 显示文摘 | Yassaa N Meklati B Y Cecinato A | 2001 | Atmospheric Environment2001，35，18： | 1 |
| 19 | Particulate n-alkanes, n-alkanoic Acids and Polycyclic Aromatic Hydrocarbons in the Atmosphere of Algiers City Area 显示文摘 | Yassaa N Meklati B Y Cecinato A | 2001 | Atmospheric Environment2001，35，10： | 1 |
| 20 | Particulate n-alkanes, n-alkanoic acids and polycyclic aromatic hydrocarbons in the atmosphere of Algiers city area显示文摘 | Yassaa N Meldati B Y Cecinato A | 2001 | Atmospheric Environment2001，35，10： | 1 |
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