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| 1 | 8760例住院患者人血白蛋白临床使用分析与评价显示文摘目的:为人血白蛋白临床合理使用提供参考。方法:回顾性调查我院2014年1-12月使用人血白蛋白的住院患者病例,统计患者一般资料、用药前血清白蛋白水平、用药量、费用、用药原因等信息,并进行分析。结果:人血白蛋白使用人数最多的8个科室共8 760例患者纳入研究,占全院使用人血白蛋白住院患者的64%。其中,男性5 244例(占59.9%),女性3 516例(占40.1%),患者年龄主要集中在>30~60岁(占52.6%)。白蛋白使用人数最多的科室为普通外科(2 588例)和心血管外科(2 348例)。以国内说明书作为参照标准时,该院有8 210例(约93.7%)患者符合适应证,低蛋白血症为最常见的用药指征(占35.6%)。重症监护治疗病房人均使用量最高(152.5 g),普通外科总用药金额最高(13 334 396.4元),传染科人均使用疗程最长(10.7 d)。结论:我院存在人血白蛋白不合理使用情况,科室间使用情况存在差异。应加强对人血白蛋白使用的监督,建立合理的用药评估体系,以促进用药规范,实现医疗资源合理分配。 | 曾晶 徐萍 王清 朱艳 原海燕 肖轶雯 Andrew Cave Hoan Linh Banh | 2017 | 中国药房2017，28，8： | 18 |
| 2 | Microscopic colitis: A review of etiology, treatment and refractory disease显示文摘Microscopic colitis is a common cause of chronic,nonbloody diarrhea. Microscopic colitis is more common in women than men and usually affects patients in their sixth and seventh decade. This article reviews the etiology and medical management of microscopic colitis. The etiology of microscopic colitis is unknown, but it is associated with autoimmune disorders, such as celiac disease, polyarthritis, and thyroid disorders. Smoking has been identified as a risk factor of mi-croscopic colitis. Exposure to medications, such as non-steroidal anti-inflammatory drugs, proton pump inhibitors, and selective serotonin reuptake inhibitors, is suspected to play a role in microscopic colitis, although their direct causal relationship has not been proven. Multiple medications, including corticosteroids, anti-diarrheals, cholestyramine, bismuth, 5-aminosalicylates, and immunomodulators, have been used to treat microscopic colitis with variable response rates. Budesonide is effective in inducing and maintaining clinical remission but relapse rate is as high as 82% when budesonide is discontinued. There is limited data on management of steroid-dependent microscopic colitis or refractory microscopic colitis. Immunomodulators seem to have low response rate 0%-56% for patients with refractory microscopic colitis. Response rate 66%-100% was observed for use of anti-tumor necrosis factor(TNF) therapy for refractory microscopic colitis. Anti-TNF and diverting ileostomy may be an option in severe or refractory microscopic colitis. | Tina Park David Cave Christopher Marshall | 2015 | World Journal of Gastroenterology2015，21，29： | 9 |
| 3 | THE CASE STUDY ON THE EFFECT OF CO_2 IN CAVE ATMOSPHERE ON STABILITY OF SPELEOTHEM SCENERY IN YAOLIN CAVE, ZHEJIANG PROVINCE, CHINA显示文摘Because of the development of tourist activities and the facilities in the show cave, the closed system of show cave has been changed into the complicated open system. The great number of the visitors and the landscape lights give great deal of thermoenergy to the show cave system, especially the high intensive lights make the temperature nearby goes up very fast and reduce the humidity. After the visitors leaving and the lights switching off, the temperature goes down and humidity increases even upto saturation, the condensation taken place. In the dry seasons, the cave humidity is relative low, even down to 40 50 percent. The administrations of show cave rushes the water to clean the touristic trails and keep the high humidity as to protect the cave environment. Under the function of artificial readjustment, the humidity of Yaolin cave atmosphere reaches to 97-100 percent throughtout the year. | Song Linhua Yang Jingrong Lin Junshu Group of Karstology and Speleology, Institute of Geography, CAS, Beijing 100101 People’s Republic of ChinaWang Laihong Administration of Yaolin Cave, Tonglu County, Zhejiang Province, 311500 People’s Republic | 1997 | Journal of Geographical Sciences1997，7，3： | 8 |
| 4 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 5 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 6 | Images in emergency medicine:giant ascending aortic aneurysm dissection with hemopericardium显示文摘BACKGROUND:Acute chest pain represents a common presentation at emergency department.Aortic dissection in young patients,however,is fortunately rare.METHODS:We report a case of giant ascending aortic aneurysm with Stanford type A aortic dissection in an otherwise well 22-year-old male patient.Operative aortic valve and root replacement was undertaken with favourable outcome.RESULTS:Histopathologic examination of the resected aorta revealed acute on chronic inflammatory change with Langerhans type giant cells consistent with a diagnosis of giant cell aortitis.CONCLUSION:While uncommon,emergencies of the aorta may present in young patients.Predisposing conditions are discussed. | Boon Ong Martyn Harvey Grant Cave | 2012 | World Journal of Emergency Medicine2012，3，3： | 2 |
| 7 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 8 | Complications Associated With Double Balloon Enteroscopy at Nine US Centers显示文摘 | Lauren B. Gerson Jeffrey Tokar Michael Chiorean Simon Lo G. Anton Decker David Cave Doumit BouHaidar Daniel Mishkin Charles Dye Oleh Haluszka Jonathan A. Leighton Alvin Zfass Carol Semrad | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 9 | Factors associated with refractory pain in emergency patients admitted to emergency general surgery显示文摘BACKGROUND: Oligoanalgesia in emergency departments (EDs) is multifactorial. A previousstudy reported that emergency providers did not adequately manage patients with severe paindespite objective findings for surgical pathologies. Our study aims to investigate clinical andlaboratory factors, in addition to providers’ interventions, that might have been associated witholigoanalgesia in a group of ED patients with moderate and severe pains due to surgical pathologies.METHODS: We conducted a retrospective study of adult patients who were transferred directlyfrom referring EDs to the emergency general surgery (EGS) service at a quaternary academic centerbetween January 2014 and December 2016. Patients who were intubated, did not have adequaterecords, or had mild pain were excluded. The primary outcome was refractory pain, which wasdefi ned as pain reduction <2 units on the 0–10 pain scale between triage and ED departure.RESULTS: We analyzed 200 patients, and 58 (29%) had refractory pain. Patients with refractory painhad signifi cantly higher disease severity, serum lactate (3.4±2.0 mg/dL vs. 1.4±0.9 mg/dL, P=0.001), and lessfrequent pain medication administration (median [interquartile range], 3 [3–5] vs. 4 [3–7], P=0.001), whencompared to patients with no refractory pain. Multivariable logistic regression showed that the number of painmedication administration (odds ratio [OR] 0.80, 95% confi dence interval [95% CI] 0.68–0.98) and ED serumlactate levels (OR 3.80, 95% CI 2.10–6.80) were signifi cantly associated with the likelihood of refractory pain.CONCLUSIONS: In ED patients transferring to EGS service, elevated serum lactate levelswere associated with a higher likelihood of refractory pain. | William Gilliam Jackson FBarr Brandon Bruns Brandon Cave Jordan Mitchell Tina Nguyen Jamie Palmer Mark Rose Safura Tanveer Chris Yum Quincy K.Tran | 2021 | World Journal of Emergency Medicine2021，12，1： | 2 |
| 10 | Continuing challenges in the diagnosis and management of obscure gastrointestinal bleeding显示文摘The diagnosis and management of obscure gastrointestinal bleeding(OGIB) have changed dramatically since the introduction of video capsule endoscopy(VCE) followed by deep enteroscopy and other imaging technologies in the last decade. Significant advances have been made, yet there remains room for improvement in our diagnostic yield and treatment capabilities for recurrent OGIB. In this review, we will summarize the latest technologies for the diagnosis of OGIB, limitations of VCE, technological enhancement in VCE, and different management options for OGIB. | Veronica Baptista Neil Marya Anupam Singh Abbas Rupawala Bilal Gondal David Cave | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 2 |
| 11 | Predicting early outcomes of liver transplantation in young children: The EARLY study显示文摘AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.METHODS This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015.Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio(OR); 95%CI] or linear(effect size, ES; 95%CI) regressions. RESULTS There were 65 children, of mean age 11.9(SD 7.1) mo and weight 8.5(2.1) kg, with biliary-atresia in 40(62%), who had a living related donor [LRD; 29(45%)], split/reduced [21(32%)] or whole liver graft [15(23%)]. Outcomes after liver transplant included: ventilator-days of 12.5(14.1); pediatric intensive care unit mortality of 5(8%); re-operation in 33(51%), hepatic artery thrombosis(HAT) in 12(19%), portal vein thrombosis(PVT) in 11(17%), and any severe complication(HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32(49%) patients. Predictors of the prespecified primary outcomes on multiple regression were:(1) HAT: split/reduced(OR 0.06; 0.01, 0.76; P = 0.030) or LRD(OR 0.16; 0.03, 0.95; P = 0.044) vs whole liver graft; and(2) ventilator-days: surgeon(P < 0.05), lowest antithrombin(AT) postoperative day 2-5(ES-0.24;-0.47,-0.02; P = 0.034), and split/reduced(ES-12.5;-21.8,-3.2; P = 0.009) vs whole-liver graft. Predictors of the pre-specified secondary outcomes on multiple regression were:(1) any thrombosis: LRD(OR 0.10; 0.01, 0.71; P = 0.021) or split/reduced(OR 0.10; 0.01, 0.85; P = 0.034) vs whole liver graft, and lowest AT postoperative day 2-5(OR 0.93; 0.87, 0.99; P = 0.038); and(2) any severe complication: surgeon(P < 0.05), lowest AT postoperative day 2-5(OR 0.92; 0.86-0.98; P = 0.016), and split/reduced(OR 0.06; 0.01, 0.78; P = 0.032) vs whole-liver graft. CONCLUSION In young children, whole liver graft and surgeon was associated with more complications, and higher AT postoperative day 2-5 was associated with fewer complications early after liver transplantation. | Rashid Alobaidi Natalie Anton Dominic Cave Elham Khodayari Moez Ari R Joffe | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 12 | Industrial Organization and New Findings on the Turnover and Mobility of Firms 显示文摘 | Richard E Caves | 1998 | Journal of Economic Literature1998，4，： | 1 |
| 13 | Theory of X-ray measurement of microfibril angle显示文摘 | Cave I D | 1966 | Forest Products Journal1966，16，10： | 1 |
| 14 | The Imperfect Market For Technology Licenses显示文摘 | Caves R E | 1983 | Oxford Bulletin of Economics and Statistics1983，，： | 1 |
| 15 | 2010 International consensus on cardiopulmonary resuscitation and emergency: Part 5 : Adult basic life support 显示文摘 | Koster RW Sayre M Bothal Martin Cave DM etc | 2010 | Resuscitation2010，81，： | 1 |
| 16 | Randomized trial of endoscopic stenting versus surgical bypass in malignant low bileduct obstruction显示文摘 | Mitty R Cave DR | 1995 | Cast ro intest Endosc1995，42，3： | 1 |
| 17 | Causes of direct investment: Foreign firms'shares in Canadian and United Kingdom manufacturing industries显示文摘 | Caves R E | 1974 | The Review of Economics and Statistics1974，56，3： | 1 |
| 18 | Recurrent Tuberculosis in the United States and Canada: relapse or reinfection 显示文摘 | Jasmer RM Bozeman L Schwartzman K Cave MD Saukkonen J J Metchock B Khan A Burman WJ | 2004 | Amer J Respir Crit Care Med2004，170，12： | 1 |
| 19 | From entry barriers to mobility barriers 显示文摘 | Caves R E Porter M E | 1977 | Quarterly Journal of Economics1977，91，2： | 1 |
| 20 | The Economic Theory of Index Numbers and the Measurement of Input, Output, and Productivity 显示文摘 | Caves D W Christensen L R Diewert W E | 1982 | Econometric1982，50，6： | 1 |
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