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| 1 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 2 | Cancer chemoprevention by phytochemicals:potential molecular targets,biomarkers and animal models显示文摘最近的研究强烈显示了某些消费日报的 dietaryphytochemicals 能有癌症对转基因的老鼠癌症模型和癌症的保护的效果由代谢物从外长或内长的来源导出的致癌物,照耀和 carcinogenic 调停了。这些饮食的混合物得到的癌症保护的效果被相信对包括除去和抗氧化剂酶的细胞的防卫系统的正式就职部分地至少到期系统,以及抑制反煽动性并且反房间生长发信号小径在房间周期拘捕或 cell-death.In 达到顶点这评论,我们包括原子因素 kappaB ( NF-kappaB )的调整总结潜在的机制, cyclooxygenases-2 ( COX-2 ),使活跃之物 protein-1 ( AP-1 ), 激活mitogen 的蛋白质家族 ases ( MAPK )和阶段 II 的正式就职细胞的除去和抗氧化剂酶主要由抗氧化剂反应元素调停了()在通过 nuclearfactor-erythroid 2-related 因素 2 的这些基因( Nrf2 )的倡导者区域以内,帽子 n 领子(计算机数值控制)的一个成员basicregion白氨酸拉链抄写因素的家庭。另外,我们也用 dietarychemopreventive 混合物考察几动物模型 ofcarcinogenesis 和这些动物模型的癌症 chemopreventive 功效研究。最后,我们讨论调停的 byNrf2, NF-kappa B, AP-1, MAPKS 和 COX-2,它被认为在肿瘤开始,提升和前进起枢轴的作用处理的细胞的发信号串联,并且能为指向癌症预防和治疗的药的设计正在答应分子的目标。 | Ki Han KWON Avantika BARVE Siwang Yu Mou-Tuan HUANG Ah-Ng Tony KONG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 5 |
| 3 | Regulation of Nrf2- and AP-l-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells显示文摘 | Sujit NAIR Avantika BARVE Tin-Oo KHOR Guo-xiang SHEN Wen LIN Jefferson Y CHAN Li CAI Ah-Ng KONG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 5 |
| 4 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 5 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 6 | Silencing ofα-complex protein-2 reverses alcohol-and cytokine-induced fibrogenesis in hepatic stellate cells显示文摘Background and aim:a-complex protein-2(aCP2)encoded by the poly(rC)binding protein 2(PCBP2)gene is responsible for the accumulation of type I collagen in fibrotic livers.In this study,we silenced the PCBP2 gene using a small interfering RNA(siRNA)to reverse alcohol-and cytokine-induced profibrogenic effects on hepatic stellate cells(HSCs).Methods:Primary rat HSCs and the HSC-T6 cell line were used as fibrogenic models to mimic the initiation and perpetuation stages of fibrogenesis,respectively.We previously found that a PCBP2 siRNA,which efficiently silences expression of aCP2,reduces the stability of type I collagen mRNA.We investigated the effects of the PCBP2 siRNA on cell proliferation and migration.Expression of type I collagen in HSCs was analyzed by quantitative real-time PCR and western blotting.In addition,we evaluated the effects of the PCBP2 siRNA on apoptosis and the cell cycle.Results:PCBP2 siRNA reversed multiple alcohol-and cytokine-induced profibrogenic effects on primary rat HSCs and HSC-T6 cells.The PCBP2 siRNA also reversed alcohol-and cytokine-induced accumulation of type I collagen as well as cell proliferation and migration.Moreover,the combination of LY2109761,a transforming growth factor-b1 inhibitor,and the PCBP2 siRNA exerted a synergistic inhibitive effect on the accumulation of type I collagen in HSCs.Conclusions:Silencing of PCBP2 using siRNA could be a potential therapeutic strategy for alcoholic liver fibrosis. | Hao Liu Zhijin Chen Wei Jin Ashutosh Barve Yu-Jui Yvonne Wan Kun Cheng | 2017 | Liver Research2017，1，1： | 2 |
| 7 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 8 | Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation显示文摘 | Zhao Y Joshi-Barve S Barve S | 2004 | J Am Coll Nutr2004，23，1： | 1 |
| 9 | Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells 显示文摘 | BARVE V AHMED F ADSULE S | 2006 | J Med Chem2006，49，13： | 1 |
| 10 | NovelSchiff base copper complexes of quinoline - 2 carboxalde-hyde as proteasome inhibitors in human prostate cancerceUs显示文摘 | Shreelekha Adsule Vivek Barve Di Chen | 2006 | J Med Chem2006，49，72： | 1 |
| 11 | Palmitic acid in- duces production of proinflammatory cytokine interleukin-8 from hepatocytes 显示文摘 | Joshi-Barve S Barve SS Amancherla K | 2007 | Hepatology2007，46，3： | 1 |
| 12 | Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model显示文摘 | Khor TO Yu S Barve A | 2009 | Cancer Res2009，69，： | 1 |
| 13 | Treatment of alcoholic liver disease显示文摘 | Barve A Khan R Marsano L | 2008 | Ann Hepato12008，7，： | 1 |
| 14 | Advances in alcoholic liver disease显示文摘 | Zhenyuan Song PhD Swati Joshi-Barve PhD Shrish Barve PhD Craig J. McClain MD | 2004 | Current Gastroenterology Reports2004，，1： | 1 |
| 15 | Palmitic acidinduces production of proinflammatory cytokine interleukin-8from hepatocytes显示文摘 | Joshi-Barve S Barve SS Amancherla K | 2007 | Hepatology2007，46，3： | 1 |
| 16 | Advances in alcoholic liver disease显示文摘 | Song Z Joshi-Barve S Barve S | 2004 | Curr Gastroenterol Rep2004，6，1： | 1 |
| 17 | Synthesis,molecular characterization,and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells显示文摘 | Barve V Ahmed F Adsule S | 2006 | J Med Chem2006，49，13： | 1 |
| 18 | Novel Schiff base copper complexes of quinoline-2-carboxaldehyde as proteasome inhibitors in humanprostate cancer cells显示文摘 | ADSUL E S BARVE V CHEN D | 2006 | J Med Chem2006，49，24： | 1 |
| 19 | Synthesis,structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(Ⅳ)conjugate显示文摘 | SHUKLA R BARVE V PADHYE S | | 0，，19： | 1 |
| 20 | A novel synthesis of bromomethoxy disubstituted derivatives of benzocyoclobutenone显示文摘 | Barve P V Schiess P | 2004 | Indian J Chem Sect B2004，43，8： | 1 |
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