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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 3 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 4 | Development of a Direct Competitive Enzyme-Linked Immunosorbent Assay for the Detection of Fluoroquinolone Residues in Shrimp显示文摘 | Sheryl A. Tittlemier Jean-Marc Gélinas Guy Dufresne Mehul Haria Jessica Querry Chantal Cleroux Cathie Ménard Philippe Delahaut Gurmit Singh Nathalie Fischer-Durand Samuel Benrejeb Godefroy | 2008 | Food Analytical Methods2008，，1： | 2 |
| 5 | Permeability of shaly sands显示文摘 | Revil A Cathies L M | 1999 | Water Resources Research1999，35，3： | 1 |
| 6 | Combretastatin A4 prodrug study of effect on the growth and the microvascttlature of colorectal liver metastases in a murine modell 显示文摘 | CATHY M W VIJAYARAGAVAN M STEWART S | 2001 | Clin Cancer Res2001，7，： | 1 |
| 7 | Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques显示文摘 | Jack H Johanneke K Cathy N M | 2002 | Neurobiol Aging2002，23，4： | 1 |
| 8 | Sweet corn(Zea mays) hybrid tolerance tonicosulfuron显示文摘 | Cathy A M Harvey R G | 1992 | Weed Technology1992，，： | 1 |
| 9 | Muhifunctionality and diversity within the Plant MYB - gene family 显示文摘 | JIN H L CATHIE M | 1999 | Plant Mol Biol1999，，41： | 1 |
| 10 | Synthe- ses of C-5-spirocyclic C-glycoside SGLT2 inhibitors 显示文摘 | VINCENT M RALPH P CATHY P | 2010 | Tetrahedron Lett2010，51，14： | 1 |
| 11 | Therapeutic use of melatonin in schizophrenia:A systematic review显示文摘BACKGROUND Sleep dysfunction is a common problem in people with schizophrenia,and side effects of treatment often exacerbate metabolic and cardiovascular risk and may induce extrapyramidal side effects.Melatonin(N-acetyl-5-methoxytryptamine)is an endogenously produced hormone which has demonstrated direct and indirect antioxidant and neuroprotective effects.Previous studies have explored the use of exogenous melatonin in improving sleep outcomes in the general population,yet indications for use in schizophrenia are unclear.AIM To synthesize the evidence from clinical trials investigating prescribed melatonin as an adjunctive therapy in patients with schizophrenia.METHODS A systematic literature review of MEDLINE(Ovid),Embase,PsychINFO,and PubMed on the 27/08/20;and CINAHL and Cochrane Library databases,was conducted.Inclusion criteria were:a peer-reviewed clinical trial published in English;included a group of patients with schizophrenia;used melatonin as an adjunctive therapy;and reported any outcome of any duration.Exclusion criteria were:neurodegenerative diseases,primary sleep disorders,co-morbid substance use or animal studies.RESULTS Fifteen studies were included in the current review with the following primary outcomes:sleep(n=6),metabolic profile(n=3),tardive dyskinesia(n=3),cognitive function(n=2)and benzodiazepine discontinuation(n=1).CONCLUSION Adjunctive melatonin therapy has some positive outcomes for sleep,metabolic profile and tardive dyskinesia in patients with schizophrenia.No beneficial effect of melatonin was observed on outcomes of cognition or benzodiazepine discontinuation.Future studies utilizing larger samples and investigations specifically comparing the effect of melatonin as adjunctive therapy with different antipsychotics in patients with schizophrenia are required. | Cathy Duan Zoe M Jenkins David Castle | 2021 | World Journal of Psychiatry2021，11，8： | 1 |
| 12 | Engineering plants with increased levels of the antioxidant chlomgenic acid显示文摘 | Ricarda N Anthony JM Cathie M | 2004 | Nature Biotechnology2004，22，6： | 1 |
| 13 | Harpin, elicitor of the HR produced by the plant pathogen Erwinia amylovora 显示文摘 | WEI Z M RON J L CATHY H Z | 1992 | Science1992，257，： | 1 |
| 14 | Prospective and retrospective studies of recovery in aphasia changes in cerebral flow and language functions显示文摘 | MIMURA M KATO M CATHY J | 1998 | Brain1998，121，： | 1 |
| 15 | Engineering plants with increased levels of the antioxidant chlorogenic acid显示文摘 | Anthony JM Cathie M | 2004 | Nature Biotechnology2004，22，6： | 1 |
| 16 | Spatial competition between grasses-rates of mutual invasion between four species and the interaction with grazing显示文摘 | Silvertown J Cathy E M Pam Dale M | 1994 | Journal of Ecology1994，82，： | 1 |
| 17 | Interaction between the homeodomain proteins Cdx2 and HNFla mediates expression of the lactase-phlorizin hydrolase gene显示文摘 | Cathy M Jesper T T Spodsberg N | 2000 | Journal of Biochemical2000，346，： | 1 |
| 18 | How to consolidate urban flows of goods without setting up an urban consolidation center 显示文摘 | SARA V CATHY M FRANK W | 2012 | Pro Soc Behav Sci2012，，39： | 1 |
| 19 | Upholding theprinciples of primary care in preceptors practices 显示文摘 | Margo S R Beverley L Cathy M | 2002 | Family Medicine2002，34，10： | 1 |
| 20 | Toxicity of 1,4-dichlorobenzene in sediments to juvenile polychaete worms显示文摘 | McPherson Cathy A Tang Armando Chapman Peter M | 2002 | Marine Pollut Bulletin2002，44，： | 1 |
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