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| 1 | Damage control orthopaedics: State of the art显示文摘Damage control orthopaedics(DCO) originally consisted of the provisional immobilisation of long bone-mainly femur-fractures in order to achieve the advantages of early treatment and to minimise the risk of complications, such as major pain, fat embolism, clotting, pathological inflammatory response, severe haemorrhage triggering the lethal triad, and the traumatic effects of major surgery on a patient who is already traumatised(the 'second hit' effect). In recent years, new locations have been added to the DCO concept, such as injuries to the pelvis, spine and upper limbs. Nonetheless, this concept has not yet been validated in well-designed prospective studies, and much controversy remains.Indeed, some researchers believe the indiscriminate application of DCO might be harmful and produce substantial and unnecessary expense. In this respect, too,normalised parameters associated with the acid-base system have been proposed,under a concept termed early appropriate care, in the view that this would enable patients to receive major surgical procedures in an approach offering the advantages of early total care together with the apparent safety of DCO. This paper discusses the diagnosis and treatment of severely traumatised patients managed in accordance with DCO and highlights the possible drawbacks of this treatment principle. | Enrique Guerado Maria Luisa Bertrand Juan Ramon Cano Ana María Cerván Adolfo Galán | 2019 | World Journal of Orthopedics2019，10，1： | 16 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus显示文摘 | M.A. Burguillos N. Hajji E. Englund A. Persson A.M. Cenci A. Machado J. Cano B. Joseph J.L. Venero | 2010 | Neurobiology of Disease2010，，1： | 2 |
| 4 | Clinical features and radiological manifestations of COVID-19 disease显示文摘Coronavirus disease 2019(COVID-19)was discovered after unusual cases of severe pneumonia emerged in December 2019 in Wuhan Province(China).Coronavirus is a family of single-stranded RNA viruses.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted from person to person.Although asymptomatic individuals can transmit the virus,symptomatic patients are more contagious.The incubation period ranges from 3-7 d and symptoms are mainly respiratory,including pneumonia or pulmonary embolism in severe cases.Elevated serum levels of interleukins(IL)-2,IL-6,IL-7 indicate the presence of cytokine release syndrome,which is associated with disease severity.The disease has three main phases:Viral infection,pulmonary involvement,and hyperinflammation.To date,no treatment has proved to be safe or effective.Chest X-ray and computed tomography(CT)are the primary imaging tests for diagnosis of SARS-CoV-2 pneumonia,follow-up,and detection of complications.The main radiological findings are ground-glass opacification and areas of consolidation.The long-term clinical course is unknown,although some patients may develop pulmonary fibrosis.Positron emission tomography-computed tomography(PETCT)is useful to assess pulmonary involvement,to define the affected areas,and to assess treatment response.The pathophysiology and clinical course of COVID-19 infection remain poorly understood.However,patterns detected on CT and PETCT may help to diagnose and guide treatment.In this mini review,we analyze the clinical manifestations and radiological findings of COVID-19 infection. | Pedro Landete Carlos Andres Quezada Loaiza Beatriz Aldave-Orzaiz Susana Hernandez Muniz Antonio Maldonado Enrique Zamora Allan Charles Sam Cerna Elia del Cerro Raquel Cano Alonso Felipe Counago | 2020 | World Journal of Radiology2020，12，11： | 2 |
| 5 | Large gangliocytic paraganglioma of the duodenum:A rare entity显示文摘Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence. | Alejandra Gordillo Hernández Eduardo Dominguez-Adame Lanuza Auxiliadora Cano Matias Rosario Perez Huertas Katherine Maria Gallardo Rodriguez Purificacion Gallinato Perez Fernando Oliva Mompean | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 6 | Comparison of Effectiveness of Right Ventricular Septal Pacing Versus Right Ventricular Apical Pacing显示文摘 | Oscar Cano Joaquín Osca María-José Sancho-Tello Juan M. Sánchez Víctor Ortiz José E. Castro Antonio Salvador José Olagüe | 2010 | The American Journal of Cardiology2010，，10： | 2 |
| 7 | Parallel signalprocessing among mammalian MAPKs显示文摘 | CanoE MahadevanLC | 1995 | Trends Biochem Sci1995，20，3： | 2 |
| 8 | Weld Models Incorporating the HAZ Phase Transformation Effects, Comparison between Experimental and Numerical Results显示文摘Numerical simulations of a representative test of welding process are presented in this paper. A French vessel steel, which involves metallurgical phase transformations in solid state is considered in this work. The aim is to validate the thermal-metallurgical-mechanical models taking into account the metallurgical transformations in the finite element codes Sysweld (Framasoft) and Code Aster (EDF). The test is performed on a thin disc submitted to a thermal cycle loading by means of a CO2 laser beam, which leads to metallurgical phase transformations. The thermal, metallurgical and mechanical numerical results have been compared to the experimental results (temperatures, sizes of transformed zones, displacements and residual stresses and strains). The main objective of the numerical analysis is to have some results which enable to give some indications on the ability of the numerical codes to describe the observed phenomena. For that, it is necessary to simulate accurately the thermo-metallurgical history. The comparison of experimental results with the numerical ones leads to some interesting orientations related to the capacities of the considered models to describe the observed phenomena. | V. VINCENT(1-2), J.F. JULLIEN(1), F. FOUQUET(1) and V. CANO(3) (1) INSA de Lyon, 20 Avenue Albert Einstein, 69621 Villeurbanne Cedex, France (2) FRAMATOME, 92084 Paris La defense Cedex, France (3) EDF-DER, 1 Avenue du General de Gaulle 92141 Clamart Cedex | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 2 |
| 9 | Polymorphic sites and the mechanism of evolution in human mitochondrial DNA 显示文摘 | Cano R L Brown W M Wilson A C | 1984 | Genetics1984，106，： | 2 |
| 10 | Atmospheric corrosion in subtropical areas: Statistic study of the corrosion of zinc plates exposed to several atmospheres in the province of Santa Cruz de Tenerife (Canary Islands, Spain)显示文摘 | J. Morales F. Díaz J. Hernández-Borges S. González V. Cano | 2006 | Corrosion Science2006，，2： | 2 |
| 11 | Testosterone activates mitogen- activated protein kinase and the cAMP responses dement binding protein transcription factor in Sertoli cells 显示文摘 | Fix C Jordan C Cano P Walker WH | 2004 | Proc Natl Acad Sci USA2004，，10： | 1 |
| 12 | Selective estrogen receptor modulators and risk for coronary heart disease显示文摘 | Cano A Hermenegildo C Oviedo P | 2007 | Climacteric2007，10，2： | 1 |
| 13 | Oral antioxidants counteract the negative effects of female ageing on oocyte quantity and quality in the mouse 显示文摘 | Tarin J J Perez-Albala S Cano A | 2002 | Mol Reprod Dev2002，61，： | 1 |
| 14 | Determination of a novel fluoropyimidine 5′-deoxy-5-fluorouridine, in plasma by high-performance liquid chromatography显示文摘 | CANO JP | 1981 | J Chromatogr1981，225，2： | 1 |
| 15 | Energy consumption and message delay analysis of QoS enhanced base station controlled dynamic clustering protocol for wireless sensor networks 显示文摘 | FAPOJUWO A CANO T | 2009 | IEEE Transactions on Wireless Communications2009，8，10： | 1 |
| 16 | Bystander tumoricidal effect in the treatment of experimental brain tumors显示文摘 | Wu JK Cano WG Meylaerts SA | 1994 | Neurosurgery1994，35，： | 1 |
| 17 | The effect of estrogen replacement therapy with or without progestogen on the fibrinolytic system and coagulation inhibitors in postmenopausal status显示文摘 | Gilabert J Estelles A Cano A | 1995 | Am J Obstet Gynecol1995，173，6： | 1 |
| 18 | Strong effect of surfaces on resolution limit of negativeindex 'superlens'显示文摘 | BRATKOVSKY A M CANO A LEVANYUK A P | 2005 | Appl Phys Lett2005，87，10： | 1 |
| 19 | Thermally sprayed CaZrO3 coatings 显示文摘 | GARCIA E CANO C COYLE T W | 2008 | Journal of Thermal Spray Technology2008，17，： | 1 |
| 20 | Microbial status of apical root ca- nal system of human mandibular first molar with primary apical pe- riodontitis after' one- visit' endodontic treatment显示文摘 | Nair PNR Henry S Cano V | 2005 | Oral Surg O- ral Med Oral Pathol Oral Radiol Endod2005，99，2： | 1 |
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