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| 1 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 2 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 3 | TiO2 - B nanowires as negative electrodea for rechargeable lithium batteries显示文摘 | Armstrong A R Armstrong G Canales J | 2005 | J Power Sources2005，146，12： | 1 |
| 4 | An integrated approach for shape and topology optimization of shell structures 显示文摘 | Ansola R Canales J Tarrago J A Rasmussen J | 2002 | Computers and Structures2002，80，56： | 1 |
| 5 | Ultrasound-assisted Method for the Determination of Chemical Oxygen Demand显示文摘 | CANALS A HERNANDEZ M D R | 2002 | Analytical and Bioanalytical Chemistry2002，374，6： | 1 |
| 6 | A formal approach to component adaptation显示文摘 | Bracciali A Brogi A Canal C | 2005 | Journal of Systems and Software2005，74，1： | 1 |
| 7 | Coconut oil extraction by a new enzymatic process显示文摘 | McGlone O C Canales A L M Carter J V | 1986 | Journal of Food Science1986，51，3： | 1 |
| 8 | Nanotubes with TiO2-B structure显示文摘 | Armstrong G Armstrong A R Canales J | 2005 | Chem Commun ( Cambridge U K)2005，，19： | 1 |
| 9 | On simultaneous shape and material layout optimization of shell structures 显示文摘 | Ansola R Canales J Tarrago J A Rasmussen J | 2002 | Structural and Multidisciplinary Optimization2002，24，3： | 1 |
| 10 | Efficacy of L-propionyl eamitine treatment in patients with left ventricular dysfunction显示文摘 | Caponnetto S Canale C Masperone M A | 1994 | Eur Heart J1994，15，9： | 1 |
| 11 | Decreased sludge production strategy for domestic wastewater treatment显示文摘 | Canales A Paereilleux A Rols J L | 1994 | Water Science Technology1994，30，： | 1 |
| 12 | Flow injection method for the rapid determination of chemical oxygen de- mand based on microwave digestion and chromium speci- ation in flame atomic absorption spectrometry 显示文摘 | CUESTA A TODO L J L CANALS A | 1996 | Spec- trochim Acta Part B1996，51，14： | 1 |
| 13 | Nitrogen control of developmental phase transitions in Arabidopsis thaliana显示文摘 | Vidal E A Moyano T C Canales J | 2014 | Journal of Experimental Botany2014，65，19： | 1 |
| 14 | Assessing freshwater use in LCA:Part I-inventory modelling and characterization factors for the main impact pathways显示文摘 | MLACANALS L CHENOWETH A CHAPAGAIN S | 2008 | International Journal of Life Cycle Assessment2008，14，： | 1 |
| 15 | Decreased sludge production strategy for domestic wastewater treatment 显示文摘 | Canales A Pareilleux A Rols J L | 1994 | War Sci Tech1994，30，8： | 1 |
| 16 | Magnetic resonance cholangiopancr - eatography documents bile leak site after cholecystectomy in patients with aberrant right hepatic duct where ERCP fails 显示文摘 | Kalayci C Aisen A Canal D | 2000 | Gastrointest Endosc2000，52，2： | 1 |
| 17 | The cytotoxic properties of a plant lipid transfer protein involve membrane permeabilization of target cells显示文摘 | REGENTE M C GIUDICI A M VILLALAIN J CANAL L | 2005 | Lett in Appl Mierobiol2005，40，： | 1 |
| 18 | Saharan dust transport and high-latitude climate variability:the Alboran Sea record显示文摘 | MORENO A CACHO I CANALS M | 2002 | Quaternary Research2002，58，： | 1 |
| 19 | An integrat- ed approach for shape and topology optimization of shell struc- tures 显示文摘 | ANSOLA R CANALES J TARRAGO J A | 2002 | Computer and Structures2002，80，： | 1 |
| 20 | The impact of organic and inorganic selenium on the immune system of growing broilers submitted to immune stimulation and heat stress显示文摘 | Silva I C M Ribeiro A M L Canal C W | 2010 | Braz J Poultry Sci2010，12，4： | 1 |
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