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	题名	作者	年代	出处	被引量
1	Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC.	Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini	2018	World Journal of Gastroenterology2018，24，36：	14
2	Breakpoint of a Y chrom osome pericentric inversion in the DAZ gene area A case report 显示文摘	Causio F Canale D Schonauer L C	2000	J Reprod Med2000，45，：	1
3	Determination of IgG subclasses and avidity of antithyroid peroxidase antibodies in patients with subclinical hypothyroidism-a comparison with patients with overt hypothyroidism显示文摘	Silva L M Chavez J Canalli M H	2003	Horm Res2003，59，3：	1
4	Emerging approaches,challenges and opportunities in life cycle assessment显示文摘	Hel weg S Milái Canals L	2014	Science2014，344，6188：	1
5	Coconut oil extraction by a new enzymatic process显示文摘	McGlone O C Canales A L M Carter J V	1986	Journal of Food Science1986，51，3：	1
6	Decreased sludge production strategy for domestic wastewater treatment显示文摘	Canales A Paereilleux A Rols J L	1994	Water Science Technology1994，30，：	1
7	Flow injection method for the rapid determination of chemical oxygen de- mand based on microwave digestion and chromium speci- ation in flame atomic absorption spectrometry 显示文摘	CUESTA A TODO L J L CANALS A	1996	Spec- trochim Acta Part B1996，51，14：	1
8	Assessing freshwater use in LCA:Part I-inventory modelling and characterization factors for the main impact pathways显示文摘	MLACANALS L CHENOWETH A CHAPAGAIN S	2008	International Journal of Life Cycle Assessment2008，14，：	1
9	Decreased sludge production strategy for domestic wastewater treatment 显示文摘	Canales A Pareilleux A Rols J L	1994	War Sci Tech1994，30，8：	1
10	The cytotoxic properties of a plant lipid transfer protein involve membrane permeabilization of target cells显示文摘	REGENTE M C GIUDICI A M VILLALAIN J CANAL L	2005	Lett in Appl Mierobiol2005，40，：	1
11	The impact of organic and inorganic selenium on the immune system of growing broilers submitted to immune stimulation and heat stress显示文摘	Silva I C M Ribeiro A M L Canal C W	2010	Braz J Poultry Sci2010，12，4：	1
12	Autotoxicity in Lolium rigidum : Analyzing the role of chemically mediated interactions in annual plant populations 显示文摘	CANALS R M EMETERIO L S PERALTA J	2005	Journal of Theoretical Biology2005，235，：	1
13	A normal approximation for the chi-square distribution显示文摘	Canal L	2005	Computational Statistics & Data Analysis2005，48，4：	1
14	Polypep- tide-polymer bioconjugates显示文摘	Canalle L A Lowik D W P M van Hest J C M	2010	(2hem Soc Rev2010，39，1：	1
15	Dietary fat and ruminally protected amino acid for high producing dairy cows显示文摘	Canale C J Muller L D Mccahom H A	1990	J Dairy Sci1990，73，：	1
16	Properties of heavy ( Sf 4-6 ) earbamylated human betalipoproteins显示文摘	Canal J Girard M L	1973	Ann Biol Clin1973，31，1：	1
17	Random noise reduction显示文摘	Canales L L	1984	SEG Expand- ed Abstracts1984，，3：	1
18	Coumes- trol has neuroprotetive effets before and after global cere- bral ischemia in female rats显示文摘	Canal Castro C Paqnussat AS Orlandi L	2012	Brain Res2012，1474，：	1
19	Rapid determination of chemical oxygen demand by a semi-automated method based on microwave sample digestion, chromium(VI) organic solvent extraction and flame atomic absorption spectrometry显示文摘	Angel Cuesta José L Todol?? Juan Mora Antonio Canals	1998	Analytica Chimica Acta1998，，3：	1
20	Major hepatectomies are safe in patients with cholangiocarcinoma and jaundice显示文摘	Joan Figueras Antoni Codina-Barreras Santiago López-Ben Jordi Soriano Berta Pardina Laia Falgueras Ernesto Castro Silvia Torres-Bahi Rosa Ortiz Esther Diaz Albert Maroto Eugeni Canals	2009	Cirugía Espa?ola (English Edition)2009，，5：	1

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