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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | 地震波数据揭示Casadia俯冲带“干”的Juan De Fuca板片显示文摘俯冲板片中的水(包括孔隙水和含水矿物中的结构水)对地球圈层之间的水循环、岛弧岩浆作用和地震活动等都有至关重要的影响。但是至今尚未综合研究过一个单一板片中水的含量、储存方式(孔隙水和结构水的相对比例)和分布(在沉积物、俯冲板片上地壳、下地壳和地幔中的分配)。 | Canales J P Carbotte S M Nedimovic M R Carton H 夏群科 | 2017 | 矿物岩石地球化学通报2017，36，6： | 2 |
| 3 | TiO2 - B nanowires as negative electrodea for rechargeable lithium batteries显示文摘 | Armstrong A R Armstrong G Canales J | 2005 | J Power Sources2005，146，12： | 1 |
| 4 | An integrated approach for shape and topology optimization of shell structures 显示文摘 | Ansola R Canales J Tarrago J A Rasmussen J | 2002 | Computers and Structures2002，80，56： | 1 |
| 5 | Determination of IgG subclasses and avidity of antithyroid peroxidase antibodies in patients with subclinical hypothyroidism-a comparison with patients with overt hypothyroidism显示文摘 | Silva L M Chavez J Canalli M H | 2003 | Horm Res2003，59，3： | 1 |
| 6 | Neuroprotection through deliver of glial cell line derived neurotrophic factor by neural stem cell in a mouse model of Parkinson’s disease显示文摘 | AKERUD P CANALS J M SUNDER E Y | 2001 | J Neurosci2001，21，20： | 1 |
| 7 | How disturbance by fossorial mammals alters N cycling in a California annual grassland显示文摘 | Canals R M Herman D J Firestone M K | 2003 | Ecology2003，84，： | 1 |
| 8 | Coconut oil extraction by a new enzymatic process显示文摘 | McGlone O C Canales A L M Carter J V | 1986 | Journal of Food Science1986，51，3： | 1 |
| 9 | Nanotubes with TiO2-B structure显示文摘 | Armstrong G Armstrong A R Canales J | 2005 | Chem Commun ( Cambridge U K)2005，，19： | 1 |
| 10 | Formalizing WSBPEL business processes using process algebra显示文摘 | Camara J Canal C Cubo J | 2006 | Electronic Notes in Theoretical Computer Science2006，154，： | 1 |
| 11 | On simultaneous shape and material layout optimization of shell structures 显示文摘 | Ansola R Canales J Tarrago J A Rasmussen J | 2002 | Structural and Multidisciplinary Optimization2002，24，3： | 1 |
| 12 | Beta( 2 )-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation 显示文摘 | Aranguiz-Urroz P Canales J Copaja M | 2010 | Biochim Biophys Acta2010，1812，1： | 1 |
| 13 | Decreased sludge production strategy for domestic wastewater treatment显示文摘 | Canales A Paereilleux A Rols J L | 1994 | Water Science Technology1994，30，： | 1 |
| 14 | Experimental diabetes trea ted with ficus carica extract: effect on oxidative stress parame ters显示文摘 | Perez C Canal J R Torres M D | 2003 | ActaDiabetol2003，40，1： | 1 |
| 15 | Flow injection method for the rapid determination of chemical oxygen de- mand based on microwave digestion and chromium speci- ation in flame atomic absorption spectrometry 显示文摘 | CUESTA A TODO L J L CANALS A | 1996 | Spec- trochim Acta Part B1996，51，14： | 1 |
| 16 | Nitrogen control of developmental phase transitions in Arabidopsis thaliana显示文摘 | Vidal E A Moyano T C Canales J | 2014 | Journal of Experimental Botany2014，65，19： | 1 |
| 17 | Decreased sludge production strategy for domestic wastewater treatment 显示文摘 | Canales A Pareilleux A Rols J L | 1994 | War Sci Tech1994，30，8： | 1 |
| 18 | The cytotoxic properties of a plant lipid transfer protein involve membrane permeabilization of target cells显示文摘 | REGENTE M C GIUDICI A M VILLALAIN J CANAL L | 2005 | Lett in Appl Mierobiol2005，40，： | 1 |
| 19 | An integrat- ed approach for shape and topology optimization of shell struc- tures 显示文摘 | ANSOLA R CANALES J TARRAGO J A | 2002 | Computer and Structures2002，80，： | 1 |
| 20 | Autotoxicity in Lolium rigidum : Analyzing the role of chemically mediated interactions in annual plant populations 显示文摘 | CANALS R M EMETERIO L S PERALTA J | 2005 | Journal of Theoretical Biology2005，235，： | 1 |
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