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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | The management of intractable bone pain:a clinical perspective 显示文摘 | Campe J A Payne R | 1992 | Semin Nucl Med1992，22，： | 1 |
| 4 | Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regula-ted manner显示文摘 | Abella A Garcia-Vicente S Viguerie N Ros-Baro A Camps M Palacin M | 2004 | Diabetologia2004，47，3： | 1 |
| 5 | The identification of KRAS mutations at eodon 12 in plasma DNA is not a prognostic fac- tor in advanced non-small cell lung cancer patients显示文摘 | Camps C Jantus-Lewintre E Cabrera A | 2011 | Lung Canc- er2011，72，3： | 1 |
| 6 | β-catenindysregulation in thyroid neoplasms:down-regulation,aberrantnuclear expression,and CTNNBl exon 3 mutations are markers foraggressive tumor phenotypes and poor prognosis显示文摘 | Garcia-Rostan G Camp RL Herrero A | 2001 | Am J Pathol2001，158，3： | 1 |
| 7 | A role for XRCC2gene polymorphisms in breast cancer risk and survival显示文摘 | Lin W Y Camp N J Cannon-Albright L A | 2011 | J Med Genet2011，48，7： | 1 |
| 8 | High performance Nd2Fe14B magnets 显示文摘 | Kim A S Camp F E | 1996 | J Appl Phys1996，79，08： | 1 |
| 9 | L- band sea surface emissivity: Preliminary results of the WISE- 2000 campaign and its application to salinity retrieval in the SMOS mission显示文摘 | CAMPS A CORBELLA I VALL-LLOSSERA M | 2003 | Radio Science2003，38，4： | 1 |
| 10 | Strategic Entrepreneurship: Entrepreneurial Strategies for Wealth Creation 显示文摘 | HITT M A IRELAND R D CAMP S M | 2001 | Strategic Management Journal2001，22，6： | 1 |
| 11 | External ven- tricular drain insertion accuracy: is there a need for change in practice? 显示文摘 | Toma A K Camp S Watkins L D | 2009 | Neurosurgery2009，65，6： | 1 |
| 12 | Dual-Beam Interferometry for Ocean Surface Current Vector Mapping显示文摘 | Frasierg S J Camps A J | 2001 | Geosuence and Remote Sensing2001，39，2： | 1 |
| 13 | Efficacy of Muscodor albus forthe control of Phytophthora blight of sweet pepper and butternutsquash 显示文摘 | Camp A R Dillard H R Smart C D | 2008 | Plant Disease2008，92，11： | 1 |
| 14 | Exploring determinants of success in corporate ventures 显示文摘 | Miller A Camp B | 1985 | Journal of Business Ventu- ring1985，1，2： | 1 |
| 15 | Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the International Subarachnoid Aneurysm Trial (ISAT)显示文摘 | Camp i A Ramzi N Molyneux AJ | | 0，，： | 1 |
| 16 | Strategic entrepreneurship : entrepreneurial strategies for wealth creation 显示文摘 | HITI' M A IRELAND R D CAMP S M | 2001 | Strategic management journal2001，22，67： | 1 |
| 17 | Regulation of sulfate assimilation by nitrogen in Arabidopsis显示文摘 | Koprivova A Suter M Camp R O | 2000 | Plant Physiol2000，122，： | 1 |
| 18 | Bowel injury in gynecologic laparoecopy显示文摘 | Brosens I Gordon A Campe R | 2003 | J Am Assoc Gynecol Laparoec2003，10，1： | 1 |
| 19 | Examination of bacteriophage as a biocontrol method for salmonella on fresh-cut fruit:a model study显示文摘 | Leverentz B Conway WS Alavidze Z Janisiewicz WJ Fuchs Y Camp MJ Chighladze E Sulakvelidze A | 2001 | 64(8):1116~11212001，64，8： | 1 |
| 20 | Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis显示文摘 | Cox A Camp NJ Cannings C | 1999 | Hum Molec Genet1999，8，： | 1 |
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