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| 1 | First-line eradication of Helicobacter pylori:Are the standard triple therapies obsolete? A different perspective显示文摘Studies concerning the eradication of Helicobacter pylori have resulted in a proliferation of meta-analyses. To date, there are 303 meta-analyses cited in PubMed, 113 dealing with the therapy of the infection. A chronological analysis of the results of meta-analyses performed between 1998 and 2010 shows that first-line standard triple therapies achieved eradication rates on an intention-to-treat basis of around 80%; prolonging treatment to 14, but not 10 d should improve the results. The proton pump inhibitors have a similar efficiency, and giving a double dose is more efficient than the standard doses of these drugs. Triple and quadruple therapies proved to be equivalent. Based on meta-analytical data, the decrease in efficiency over time cannot be substantiated: eradication rates < 80% followed from the introduction of triple therapies. As alternatives, ranitidine bismuth citrate-, levofloxacinor furazolidone-based therapies were shown to obtain the same eradication rates as standard triple regimens. Sequential therapies and quadruple non-bismuth-based therapies were superior to standard triple therapies but their use is limited to certain countries. In the author's opinion, and from a meta-analytical viewpoint, standard triple therapies cannot yet be considered obsolete. Furthermore, noninferiority trials are proposed for the future, including assessment of local contemporary antimicrobial resistance profi les and the CagA and CYP2C19 status of the enrolled patients. | Gyrgy Miklós Buzás | 2010 | World Journal of Gastroenterology2010，16，31： | 26 |
| 2 | Metabolic consequences of Helicobacter pylori infection and eradication显示文摘Helicobacter pylori(H.pylori)is still the most prevalent infection of the world.Colonization of the stomach by this agent will invariably induce chronic gastritis which is a low-grade inflammatory state leading to local complications(peptic ulcer,gastric cancer,lymphoma)and remote manifestations.While H.pylori does not enter circulation,these extragastric manifestations are probably mediated by the cytokines and acute phase proteins produced by the inflammed mucosa.The epidemiologic link between the H.pylori infection and metabolic changes is inconstant and controversial.Growth delay was described mainly in low-income regions with high prevalence of the infection,where probably other nutritional and social factors contribute to it.The timely eradication of the infection will lead to a more healthy development of the young population,along with preventing peptic ulcers and gastric cancer An increase of total,low density lipoprotein and high density liporotein cholesterol levels in some infected people creates an atherogenic lipid profile which could promote atherosclerosis with its complications,myocardial infarction,stroke and peripheral vascular disease.Well designed and adequately powered long-term studies are required to see whether eradication of the infection will prevent these conditions.In case of glucose metabolism,the most consistent association was found between H.pylori and insulin resistance:again,proof that eradication prevents this common metabolic disturbance is expected.The results of eradication with standard regimens in diabetics are significantly worse than in non-diabetic patients,thus,more active regimens must be found to obtain better results.Successful eradication itself led to an increase of body mass index and cholesterol levels in some populations,while in others no such changes were encountered.Uncertainities of the metabolic consequences of H.pylori infection must be clarified in the future. | Gy?rgy Miklós Buzás | 2014 | World Journal of Gastroenterology2014，20，18： | 20 |
| 3 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 4 | First-line eradication of H pylori infection in Europe:A metaanalysis based on congress abstracts,1997-2004显示文摘AIM: To meta-analyse the Europeans presented between 1997-2004 at the European H pylori Study Group, United European Gastroenterology Week meetings and World Congresses of Gastroenterology. METHODS: The abstracts of randomized/controlled prospective studies were classified into groups based on first-line eradication schedules. The quality of the abstracts was checked by a validated score system. The pooled eradication rates (PER) and combined odds ratios (OR) were calculated and compared with the published meta-analyses.RESULTS: The PER of proton pump inhibitor-based (PPI) one week triple therapies was 81.4% (confi dence interval, 95% CI: 78.5-84.5). Ranitidine bismuth citrate-based (RBC) triple regimens have an efficiency rate of 78.5% (95% CI: 70.5%-84.3%) (P = 0.28 vs PPI). The OR for PPI effect vs RBC regimens was 1.1 (95% CI: 0.92-1.30). H2 receptor antagonist-based triple therapies achieved 64.1% (95% CI: 52.6-75.6) (P = 0.02 < 0.05 vs PPI), the OR vs PPI regimens was 1.55 (95% CI: 0.72-3.78). PPI-based double combinations were less efficient than triple regimens (PER: 55.0%, OR: 4.90, 95% CI: 2.36-9.70). Quadruple regimens were successful in 82.6% (95% CI: 76.0-89.7), the OR vs triple therapies was 0.80 (0.62-1.03). Clarithromycin + amoxicillin or nitroimidazole combinations were effi cient in 80.5% (95% CI: 77.2-84.2) and 83.8% (95% CI: 81.7-85.9), respectively. Amoxicillin + nitromidazole therapies eradicated the infection in 73.5% (66.6-78.5) (P = 0.01 < 0.05 vs clarithromycin-based regimens). CONCLUSION: PPI/RBC-based triple therapies achieved comparable results with the meta-analyses. H2-receptor antagonists and PPI-based double combinations were less efficient. Triple and quadruple regimens wereequally effective. Clarithromycin + either amoxicillin or nitroimidazole containing regimens were more effective than amoxicillin + nitroimidazole combinations. High quality congress abstracts constitutes a valuable pool of data which is suitable for meta-analytical workup. | Gyrgy M Buzás Jolán Józan | 2006 | World Journal of Gastroenterology2006，12，33： | 5 |
| 5 | Relationship between plasma melatonin levels and the efficacy of selective serotonin reuptake inhibitors treatment on premature ejaculation 显示文摘 | Sinan Levent Kirecci Abdulmuttalip Simsek Zafer Gokhan Gur- buz | 2014 | International Journal of Urology2014，21，： | 1 |
| 6 | Tasks for inhibitory interneurons in intact brain circuits显示文摘 | Roux L Buzski G | 2015 | Neuropharmacology2015，88，： | 1 |
| 7 | Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis 显示文摘 | Peng Q L Buz'Zard A R Lau B H | 2002 | Brain Res Mol Brain Res2002，104，1： | 1 |
| 8 | Pycnogenol R protects neurons from amyloid-β peptide-induced apoptosis显示文摘 | Peng Q Buz' Zard A Lau B | 2002 | Mol Brain Res2002，104，1： | 1 |
| 9 | Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus显示文摘 | Nagy G Koncz A Telarico T Fernandez D Ersek B Buzás E Perl A | | 0，，03： | 1 |
| 10 | Host–parasite relationships of Schistosoma japonicum in mammalian hosts显示文摘 | Yi-Xun He Buz Salafsky Kalyanasundaram Ramaswamy | 2001 | Trends in Parasitology2001，，7： | 1 |
| 11 | Memory,navigation and thetarhythm in the hippocampal-entorhinal system显示文摘 | Buzsáki G Moser EI | 2013 | Nat Neurosci2013，16，2： | 1 |
| 12 | Successful treatment of endoleak type I with uncovered EX-L stent after thoracic endovascular aneurysm repair显示文摘 | Buz S Zipfel B Ancona G | 2013 | Interact Cardiovasc Thorac Surg2013，16，4： | 1 |
| 13 | Conventional surgical repair and endo- vasculartreatment of acute traumatic aortic rupture 显示文摘 | Buz S Zipfel B | 2008 | Eur J Cardiothorac Surg2008，32，14： | 1 |
| 14 | Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis显示文摘 | Peng QL Buz'Zard AR Lau BH | 2002 | Brain Res Mol Brain Res2002，104，： | 1 |
| 15 | Transapical transcatheter aortic valve replacement in patients with cardiogenic shock显示文摘 | D'Ancona G Pasic M Buz S | | 0，，： | 1 |
| 16 | Conventional surgical repair and endovascular treatment of acute traumatic aortic rupture显示文摘 | Buz S Zipfel B Mulahasanovic S | 2008 | Eur J Cardiothorac Surg2008，33，1： | 1 |
| 17 | Radiation therapy for the management of painful bone metastases: Results from a randomized trial显示文摘 | Lucia Gutiérrez Bayard María del Carmen Salas Buzón Esther Angulo Paín Lourdes de Ingunza Barón | 2014 | Reports of Practical Oncology & Radiotherapy2014，，： | 1 |
| 18 | Aging and social networks in Spain:the importance of pubs and churches显示文摘 | Buz J Sanchez M Levenson MR | 2014 | Int J Aging Hum Dev2014，78，1： | 1 |
| 19 | Poly( lactic acid)- based biocomposites reinforced with kenaf fibers 显示文摘 | Avella M Bogoeva-Gaceva G Buz arovska B | 2008 | Journal of Applied Polymer Science2008，108，： | 1 |
| 20 | High-dose aprotinin effectively reduces blood loss during on-pump coronary artery bypass grafting with bivalirudin anticoagulation显示文摘 | Buz S Krabatsch T | 2008 | J Thorac Cardiovasc Surg2008，135，： | 1 |
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