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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | The efficacy of hypert0nic saline nasal irrigation for chronic sinonasal symptoms 显示文摘 | Rabago D Pasic T Zgierska A | 2005 | Otolar- yngol Head Neck Surg2005，133，1： | 1 |
| 3 | Treatment of vitiligo withnarrow-band UVB and topical gel containing catalase andsuperoxide dismutase 显示文摘 | Kostovic K Pastar Z Pasic A | 2007 | Acta Dermatovenerol Croat2007，15，1： | 1 |
| 4 | The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms显示文摘 | Rabago D Pasic T Zgierska A | 2005 | Otolaryngol Head Neck Surg2005，133，1： | 1 |
| 5 | Transapical aortic valve implantation after previous aortic valve replacement : clinical proof of the 'valve - in - valve' concept 显示文摘 | Pasic M | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，142，2： | 1 |
| 6 | New trends in the immunopathogenesis of psoriasis 显示文摘 | Kastelan M Massari LP Pasic A Gruber F | 2004 | Acta Dermatovenerol Croat2004，12，1： | 1 |
| 7 | Endothelial cell seeding improves patency of synthetic vascular grafts:manual versus automatized method显示文摘 | Pasic M Muller Glauser W Von Segesser L | 1996 | Eur J Cardiothorac Surg1996，10，： | 1 |
| 8 | Endothelial cell See-ding improves patency of synthetic vascular grafts: manual versus Autom-atized method显示文摘 | Pasic M Muller Glauser W Von Segesser L | 1996 | Eur J Cardiothorac Surg1996，10，： | 1 |
| 9 | New trends in the immune pathogenesisof psoriasis显示文摘 | KsatelanM Massari LP Pasic A | 2004 | Acta Dermatoven2 erol Croat2004，，12： | 1 |
| 10 | New trends in the immunopa thogenesis of psoriasis 显示文摘 | Kastelan M Massari LP Pasic A | 2004 | Acta Dermatovenerol Croat2004，12，1： | 1 |
| 11 | Intraoperative radiofrequency maze ablation for atrial fibrillation:the Berlin modification 显示文摘 | PASIC M BERGS P MULLER P | 2001 | Ann Thorac Surg2001，72，5： | 1 |
| 12 | Lupus nephritis in childhood:a review of 53 patients followed at a single center显示文摘 | Bogdanovic R Nikolic V Pasic S | 2004 | Pediatr Nephrol2004，19，： | 1 |
| 13 | Stentless bio prosthesis centre experience in a subgroup of 255 patients treated with the Shelhighsurgical therapy in patients with active infective endocarditis: seven-year Single 显示文摘 | Musci M Siniawski H Pasic M | 2008 | Eur J Cardiothorac Surg2008，34，41： | 1 |
| 14 | New trends in the immunopathogenesis of psoriasis显示文摘 | Kastelan M Massari LP Pasic A | 2004 | Acta DermatovenerolCroat2004，12，1： | 1 |
| 15 | Intact ectopic pregnancy found at laparoscopic salpingectomy 显示文摘 | Yeung PP Jr Pasic RP | 2008 | J Minim Invasive Gyn ecol2008，15，4： | 1 |
| 16 | Nasal schwannoma显示文摘 | Pasic TR Makielski K | 1990 | Otolaryngol Head Neck Surg1990，103，6： | 1 |
| 17 | Combined elective percutaneous coronary intervention and transapical transcatheter aortic valve implantation显示文摘 | Pasic M Dreysse S Unbehaun A | | 0，，： | 1 |
| 18 | Fertility sparing endometriosis surgery: A review显示文摘Background:Endometriosis is a chronic inflammatory condition involving endometrial-like tissue outside of the uterus.There are no medical management options available to improve fertility in patients with known endometriosis prior to conception.Specifically,the fertility sparing surgical techniques used to manage endometriomas and colorectal endometriosis are controversial prior to natural conception and implementing assisted reproductive technology.Methods:A literature search,including PubMed and the Cochrane Library,was performed from November 2020 to February 2021 and articles in English that addressed endometriosis associated infertility and surgical treatments were included.Our review provides a comprehensive evidence-based evaluation of fertility sparing endometriosis surgery.Results:The pathogenesis of endometriosis and its role in infertility is poorly understood and complex.The management of patients with painful endometriomas continues to be excision,whereas small asymptomatic endometriomas require an individualized approach.Colorectal endometriosis excision improves pregnancy rates in retrospective and prospective cohort studies.However,randomized control trials are still needed to confirm these findings and their functional risks must be carefully discussed with the patient.Conclusions:Surgical excision of endometriosis improves fertility in patients with symptomatic disease.Further research with randomized controlled trials is needed to determine if surgery is mandatory prior to implementing assisted reproductive technologies in those patients with asymptomatic endometriosis and infertility. | Amira Quevedo Resad Pasic Alexandria Connor Petra Chamseddine | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，3： | 1 |
| 19 | Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients 显示文摘 | PASIC A VONK-NOORDEGRAAF A RISSE E K | 2003 | Lung Cancer2003，41，3： | 1 |
| 20 | Lupus nephritis in childhood:a review of 53 patients followed at a single center显示文摘 | Bogdanovic R Nikolic V Pasic S | 2004 | 19(1):36-442004，19，1： | 1 |
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