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290篇 您的检索式：作者名="Brun G"

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	题名	作者	年代	出处	被引量
1	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.	Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol	2016	World Journal of Hepatology2016，8，21：	5
2	Follicular pattern of marrow involvement by follicular lymphoma显示文摘	Torlakovic E Torlakovic G Brunning RD	2002	AmJ Glin Pathol2002，118，5：	1
3	Does axillary liposuction modify histologie study of excised lymph nodes? 显示文摘	Brun JL Belleannee G Rousseau E	1997	J Gynecol Obstet Biol Repord1997，26，5：	1
4	Glucose instanility is associated with a high level of circulating p-selectin显示文摘	Brun E Zoppini G Zamboni C	2001	Diabetes Care2001，24，9：	1
5	Techniques of coilingcerebral aneurysms显示文摘	Aletich V A Thornton J etal	2000	Surg Neurol2000，53，：	1
6	Psychosocial support for pulmonary rehabilitation in patients with chronic obstructive pulmonary disease 显示文摘	Ninot G Brun A Queiras G	2003	Rev Mal Respir2003，20，4：	1
7	Nucleosomes are major T and B ceil autoantigens in sys-emic lupus erythematosus显示文摘	Bruns A Blass S Hausdorf G	2000	Arthritis Rheum2000，43，10：	1
8	The indications for laparoscopy in malignant tumours of the ovary显示文摘	Cossard F Brun G	1979	J Gynecol Obstet Biol Reprod (Paris)1979，8，6：	1
9	Closing the Gap between Values and Behavior-A Means-End Theory of Lifestyle 显示文摘	Bruns K Scholderer J Grunert K G	2004	Journal of Business Research2004，57，6：	1
10	Effects of zinc supplementation on blood rheology during excrcise显示文摘	Khaled S Brun JF Cassanas G		0，，：	1
11	An interview with Nancy Dushkin, VP discovery and delivery solutions at Ex Libris, Regarding Primo cen- tral显示文摘	Brunning D Machovec G	2010	The Charleston Advisor2010，12，2：	1
12	The physiology and pharmacology of melatonin in humans显示文摘	Geoffriau M Brun J Chazot G	1998	Horm Res1998，49，：	1
13	Absorption coeffi- cient of silicon :An assessment of measurements and the simulation of temperature variation 显示文摘	Bucher K Bruns J Wagemann H G	1994	J Appl Phys1994，75，2：	1
14	257 ankle arthroplasties performed in Norway between 1994 and 2005显示文摘	Bj?rg-Tilde S Fevang Stein A Lie Leif I Havelin Johan G Brun Arne Skredderstuen Ove Furnes	2007	Acta Orthopaedica2007，，5：	1
15	Physical processes and regimes of thermomechanical processing controlling development of regulated structure in the c + 13 titanium alloys 显示文摘	Brun M Anoshkin N Shakhanova G	1998	Materials Science and Engineering : A1998，243，：	1
16	Core Self-evaluations : A Predictor Variable for Job Stress显示文摘	BRUN BORG G S	2008	European Psychologist2008，13，2：	1
17	Cementless fixation of megaprostheses using a conical fluted stem in the treatment of bone tumours显示文摘	Bruns J Delling G Gruber H	2007	J Bone Joint Surg Br2007，89，8：	1
18	Physical processes and regimes of thermomechanical processing controlling development of regulated structure in the α+β titanium alloys显示文摘	Brun M Anoshkin N Shakhanova G	1998	Materials Science and Engineering1998，243，：	1
19	Pristane-induced arthritis in rats:a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompafibility complex genes显示文摘	Vingsbo C Sahlslrand P Brun J G	1996	Am J Pathol1996，149，5：	1
20	Enzyme-linked immu-nosorbent assay for the organophosphorus insecticide fenthi-on:Influence of hapten structure显示文摘	Brun E M Marta G G Rosa P	2004	Journal of Immunologi-cal Methods2004，295，：	1

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