|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dopamine: an immune transmitter显示文摘The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies. | Sarah Thomas Broome Krystal Louangaphay Kevin AKeay Gian Marco Leggio Giuseppe Musumeci Alessandro Castorina | 2020 | Neural Regeneration Research2020，15，12： | 5 |
| 2 | 美国杜克大学护理发展卓越中心院校合作介绍及启示显示文摘介绍美国杜克大学护理发展卓越中心的成立背景、组织目标和架构以及工作内容,为深入推动中国护理院校合作提供借鉴。 | 成磊 Staci Reynolds Mary Ann Fuchs Marion Broome | 2019 | 中华护理杂志2019，54，3： | 4 |
| 3 | Mycotoxins and the intestine显示文摘Fungal biochemical pathways can yield various compounds that are not considered to be necessary for their growth and are thus referred to as secondary metabolites. These compounds have been found to have wide ranging biological effects and include potent poisons(mycotoxins). Mycotoxins invariably contaminate crops and(thus) animal feeds. The intestine is the key link between ingested mycotoxins and their detrimental effects on the animal. Effects on the intestine, or intestinal environment, and immune system have been reported with various mycotoxins. These effects are almost certainly occurring across species. Most, if not all, of the reported effects of mycotoxins are negative in terms of intestinal health, for example, decreased intestinal cell viability, reductions in short chain fatty acid(SCFA)concentrations and elimination of beneficial bacteria, increased expression of genes involved in promoting inflammation and counteracting oxidative stress. This challenge to intestinal health will predispose the animal to intestinal(and systemic) infections and impair efficient digestion and absorption of nutrients, with the associated effect on animal productivity. | Leon Broom | 2015 | Animal Nutrition2015，，4： | 2 |
| 4 | Hepatic and extrahepatic malignancies in primary sclerosing cholangitis显示文摘 | Annika Bergquist Anders Ekbom Rolf Olsson Dan Kornfeldt Lars L??f ?ke Danielsson Rolf Hultcrantz Stefan Lindgren Hanne Prytz Hanna Sandberg-Gertzén Sven Almer Fredrik Granath Ulrika Broomé | 2002 | Journal of Hepatology2002，，3： | 2 |
| 5 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 6 | Effects of zinc oxide and Enterococcus faecium SF68 dietary supplementation on the performance, intestinal microbiota and immune status of weaned piglets显示文摘 | L.J. Broom H.M. Miller K.G. Kerr J.S. Knapp | 2005 | Research in Veterinary Science2005，，1： | 2 |
| 7 | Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins 显示文摘 | Schlaepfer DD Broome MA Hunter T | 1997 | Mol Cell Biol1997，17，3： | 2 |
| 8 | The use of tramadol of following day-case oral surgery显示文摘 | Broome I J Robb HM Rai N | 1999 | Anaesthesia1999，54，3： | 1 |
| 9 | Fibronectin-stimulated signaling from a focal adhesion kinase- c- Src complex: involvement of the Grb2, p130 cas, and Nck adaptor proteins显示文摘 | Broome MA Hunter T | 1997 | Mol Cell Biol1997，17，3： | 1 |
| 10 | Synthesis and biological activity of selected 2,6-disubstituted- (2-deoxy-α- and -β-D-erythropentofuranosyl) purines 显示文摘 | Christensen LF Broom AD | 1972 | J Med Chem1972，15，7： | 1 |
| 11 | The scientific misconduct questionnaire -revised ( SMQ - R ) : validation and psychometric testing 显示文摘 | Broome M E Pryor E Habermann B Pulley L Kincaid H | 2005 | Accountability in Research2005，12，4： | 1 |
| 12 | Recovery from opioid addiction in DATOS 显示文摘 | Flynn PM Joe GW Broome KM | 2003 | Subst Abuse Treat2003，25，3： | 1 |
| 13 | Primary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential显示文摘 | Ulrika Broomé Robert L?fberg Béla Veress Ljusk Siw Eriksson | 1995 | Hepatology1995，，5： | 1 |
| 14 | Epidemiology of Murray Valley encephalitis and Kunjin viruses in Western Aus tralia 显示文摘 | Broom AK Mackenzie JS Lindsay MD | 1989 | Arbovirus Res Aust1989，，5： | 1 |
| 15 | Mandibular osteoradione- crosis in squamous cell carcinoma of the oral cavity and orophar- ynx: incidence and risk factors 显示文摘 | Monnier Y Broome M Betz M | 2011 | Otolaryngol Head Neck Surg2011，144，5： | 1 |
| 16 | The effect oflinoleic acid on the growth and metabolisms of Streptococcus lactis显示文摘 | BROOME M C THOMAS M P HILLIER A J | 1979 | Australian Journal of Dairy Technology1979，34，4： | 1 |
| 17 | Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs显示文摘 | Broome HE Yu AL Diccianni M | 2002 | Leuk Res2002，26，3： | 1 |
| 18 | Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells显示文摘 | Li YM Broome JD | 1999 | Cancer Res1999，59，1： | 1 |
| 19 | UIva, Umbraulva and Gemina : genetic survey of New Zealand taxa reveals diversity and in- troduced species 显示文摘 | Heesch S Broom J E S Neill K F | 2009 | European Journal of Phycology2009，44，2： | 1 |
| 20 | Different expression of HLA-DR and ICAM-1 in livers from patients with biliary atresia and Byler' s disease显示文摘 | Broomé U Nemeth A Hultcrantz R | 1997 | J Hepatol1997，26，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员