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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Brian L Smith Billy M Williams R Keith Oswald | 2002 | Transportation Research Part C2002，，4： | 3 |
| 3 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 4 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 5 | Comparison of parametric and nonparametric models显示文摘 | Brian L Smith Billy M Williams R Keith Oswald | 2002 | Transportation Research Part C2002，，10： | 1 |
| 6 | High-level production of recombinant proteins in CHO cells using a dicistronic DHFR intron expression vector显示文摘 | Brian K L Lynne M G Richard A | 1996 | Nucleic Acids Research1996，24，9： | 1 |
| 7 | Antifouling enzymes and the biochemistry of marine settlement显示文摘 | Jakob B K Rikke L M Brian S L | 2008 | Biotechn Adv2008，26，： | 1 |
| 8 | The effect of operational parameters on the photocatalytic degradation of humic acid显示文摘 | Fiona L Palmer Brian R Eggins Heather M Coleman | 2002 | Journal of Photochemistry & Photobiology, A: Chemistry2002，，1： | 1 |
| 9 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Brian L Smith Billy M Williams and R Keith Oswald | 2002 | Transportation Research Part C: Emerging Technologies2002，10，4： | 1 |
| 10 | Educational Applications of IR and RamanSpectroscopy:A Comparison of Experiment and Theory显示文摘 | Brian L M Sara M C | 2000 | Chemi-cal Education2000，77，5： | 1 |
| 11 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 12 | Medical students as standardized patients to assess inter-viewing skills for pain evaluation显示文摘 | Brian E Mavis Karen SOgle Kathryn L Lovell&Lisa M Mad-den | 2002 | Medical Education2002，36，： | 1 |
| 13 | Low-temperature polyol synthesis of AuCuSn2 and AuCuSn2:using solution chemistry to access ternary intermetallic compounds as nanocrystals显示文摘 | Brian M L Nattamai S P B Raymond E S | 2005 | JACS2005，，： | 1 |
| 14 | Maca: An Andean crop with multi-pharmacological functions显示文摘 | Wang Y L Wang Y C Brian M N | 2007 | Food Research International2007，40，7： | 1 |
| 15 | Concept maps as hypermedia components 显示文摘 | BRIAN R G SHAW M L G | 1995 | International Journal of Human - Computer Studies1995，43，3： | 1 |
| 16 | Does Perceived Organizational Support Mediate the Relationship between Procedural Justice and Behavior? 显示文摘 | Robert H M Gerald L B Brian P N | 1998 | Academy of Organizational Citizenship Management Journal1998，41，3： | 1 |
| 17 | Comparison of parametric and nonparametric models for traffic flow forecasting显示文摘 | Smith Brian L Williams Billy M Oswald Keith R | 2002 | Transportation Research Part C2002，10，： | 1 |
| 18 | Improvement in the solution stability of porcine somatotropin by chemical modification of cysteine residues 显示文摘 | Brian L Buckwalter Susan M Cady Hong-Ming Shieh | 1992 | J Agric Food Chem1992，40，： | 1 |
| 19 | Effects of global climate change on agriculture : an interpretative review显示文摘 | Richard M A Brian H H Stephanie L | 1998 | Climate Research1998，11，： | 1 |
| 20 | Flights and conta-gion-an empirical analysis of stock - bond correlations显示文摘 | BAUR D G BRIAN M L | 2009 | Journal of Financial Stability2009，5，4： | 1 |
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