|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Advances in cellulose ester performance and application显示文摘 | Kevin J Edgar Charles M Buchanan John S Debenham Paul A Rundquist Brian D Seiler Michael C Shelton Debra Tindall | 2001 | Progress in Polymer Science2001，，9： | 2 |
| 4 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 5 | Hemoglobin Concentrations Influence Birth Outcomes in Pregnant Afican- American Adolesents显示文摘 | Chang S C O'Brian K O Nathanson M S | | 0，，07： | 1 |
| 6 | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography显示文摘 | Scott C Kruger Brian T McAlice | 1999 | Journal of Chromatography A1999，859，： | 1 |
| 7 | Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals 显示文摘 | BRIAN J V HARRIS C A SCHOLZE M | 2005 | Environ Health Perspect2005，113，： | 1 |
| 8 | Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Thl and Th2 cell dDifferentiation显示文摘 | NATALLIA M BRIAN B MICHAEL A C | 2006 | The Journal of Immunology2006，176，： | 1 |
| 9 | Educational Applications of IR and RamanSpectroscopy:A Comparison of Experiment and Theory显示文摘 | Brian L M Sara M C | 2000 | Chemi-cal Education2000，77，5： | 1 |
| 10 | Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model显示文摘 | Brian B C Huang Y Goettl V M | 2005 | Brain Res2005，1041，1： | 1 |
| 11 | Maca: An Andean crop with multi-pharmacological functions显示文摘 | Wang Y L Wang Y C Brian M N | 2007 | Food Research International2007，40，7： | 1 |
| 12 | Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals 显示文摘 | BRIAN V HARRIS C A SCHOLZE M | 2005 | Environ Health Perspect2005，113，6： | 1 |
| 13 | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography显示文摘 | Scott C Kruger Brian T McAlice | 1999 | Journal of Chromatography A1999，859，： | 1 |
| 14 | Dealing with globalisation at the regional and local level:The case of contemporary containerization显示文摘 | Robert J M Brian S Claude C | 2004 | The Canadian Geographer2004，48，4： | 1 |
| 15 | The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation 显示文摘 | Augustine C Julia D Brian M | 2012 | Science2012，338，6110： | 1 |
| 16 | Fibre optic oxygen sensor based on fluorescence quenching of evanescent - wave excited ruthenium complexes in sol--gel derived porous coatings 显示文摘 | BRIAN D MACCRAITH MCDONSGH C M | 1993 | Analyst1993，118，4： | 1 |
| 17 | Population changes in Phytophthora infestans in Taiwan associated with the appearance of resistance to metalaxyl 显示文摘 | BRIAN C M MICHELE Q RICHARD W J | 2002 | Pest Management Science2002，58，9： | 1 |
| 18 | Dynamic Measurements of Corrosion Rates at High Temperatures in High Electrical Resistivity Media显示文摘 | BRIAN N P RAJASHREEE C THOMAS M D | 2015 | Corrosion Science2015，94，： | 1 |
| 19 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 20 | Residents attitudes towards tourism in Hong Kong 显示文摘 | Connie M Brian S Vivien C | 1991 | International Journal of Hospitality Management1991，10，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员