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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | An Antifungal Tetrapeptide from the culture of Penicillium canescens 显示文摘 | Brenda V B Nora I P Gabriela M C | 2009 | Chem Biod2009，6，8： | 1 |
| 3 | Life cycle greenhouse gas assessment of infrastructure construction for California' s high-speed rail system 显示文摘 | BRENDA C ALISSA K | 2011 | Transportation Research Part D : Transport and Environment2011，16，6： | 1 |
| 4 | Plant competition underground显示文摘 | Brenda B C Robert B J | 1997 | Annual Reviews of Ecology and Systematics1997，28，： | 1 |
| 5 | Life Cycle Greenhouse Gas Assessment of Infrastructure Construction for California's High-speed Rail System显示文摘 | Brenda C Alissa K | | 0，，： | 1 |
| 6 | Hope or No-HOPE-- Merit-Based College Scholarship Status and Financial Behaviors Among College Students 显示文摘 | JOSEPH W D BRENDA J C | 2008 | Financial Counseling and Planning2008，，1： | 1 |
| 7 | Face rec- ognition performance : role of demographic information 显示文摘 | Brenda F K Mark J B Joshua C K | 2012 | IEEE Transactions on Information Forensics and Security2012，7，6： | 1 |
| 8 | Fibroblasts potentiate blood vessel formationpartially through secreted factor TIMP-1显示文摘 | Hua L Bo C Brenda L | 2008 | Angiogenesis2008，11，： | 1 |
| 9 | Effect of postharvest processing on texture profile analysis of cooked rice 显示文摘 | Elaine T C Brenda G L Bong K M | 1995 | Crereal Chemistry1995，75，2： | 1 |
| 10 | Modeling singlecomponent protein adsorption to the cation exchange s sepharrosee FF显示文摘 | GRAHAM L S BRENDA J H HOWARD A C | 1990 | Journal of Chromatography A1990，498，： | 1 |
| 11 | Seed bank formation during early secondary succession in a temperate deciduous forest 显示文摘 | Laura A H Brenda B C | 2000 | Journal of Ecology2000，88，： | 1 |
| 12 | Ubiquitin proteasome system (UPS): what can chromatin do for you?显示文摘 | Brenda C O'Connell J Wade Harper | 2007 | Current Opinion in Cell Biology2007，，2： | 1 |
| 13 | Dynamic changes in the cervical pithelial tight junction complex and differentiation occur during cervical ripening and parturition 显示文摘 | Brenda C Timmon S Shannon M | 2007 | Endocrinology2007，148，3： | 1 |
| 14 | Hydrogen: the energy source of 21 century 显示文摘 | Brenda Johnston Michael C Mayo Anshuman Khare | 2005 | Technovation2005，25，： | 1 |
| 15 | Developmental responses to sowing date in wheat, barley and rapeseed显示文摘 | Daniel J Miralles Brenda C Ferro Gustavo A Slafer | 2001 | Field Crops Research2001，71，： | 1 |
| 16 | Plant competition underground 显示文摘 | Brenda B C Robert B J | 1997 | Annual Reviews of Ecology and Systematics1997，28，： | 1 |
| 17 | Single-incision laparoscopic surgery: feasibility for pediat- ric appendectomies 显示文摘 | Sarah C Ohmann Nilda M Garcia Brenda Ventura | 2010 | J Pediatr Surg2010，45，6： | 1 |
| 18 | Effectiveness of highly active antiretroviral therapy (HAART)among HIV- infected patients in Mexico显示文摘 | Brenda C Angelina V Arturo G | 2010 | AIDS Res Hum Retroviruses2010，26，4： | 1 |
| 19 | Assessing education in pul_monary rehabilitation: the understanding COPD (UCOPD) questionnaire 显示文摘 | Brenda O Denise C Joseph MM | 2012 | Journal of Chronic Obstructive Pulmonary Disease2012，，9： | 1 |
| 20 | Plant competition underground显示文摘 | Brenda B C Robert B J | 1997 | Annu-al Reviews of Ecology and Systematics1997，28，： | 1 |
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