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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | The effect of anode flow characteristics and temperature on the performance of a direct methanol fuel cell显示文摘 | JOHN C A BRANT A P ELA H | 2001 | Journal of Power Source2001，96，1： | 1 |
| 3 | Gamma glutamyltransferase as a risk factor for cardiovascular disease mortality:an epidemiological investigation in a cohort of 163,944 Austrian adults显示文摘 | Ruttmann E Brant L J Conein H Diem G Rapp K Ulmer H | 2005 | Circulation2005，112，： | 1 |
| 4 | Dielectric parameters relevant to microwave dielectric heating显示文摘 | GABRIEL C GABRIEL S BRANT E H | 1998 | Chemical Society Review1998，27，： | 1 |
| 5 | A prospective cohort study on antioxidant and folate intake and male lung cancer risk显示文摘 | Voorrips L E Goldbohm R A Brant H A M | 1998 | Cancer Epidemiol Biomark Prev1998，9，： | 1 |
| 6 | Viscoelastic behavior of thermally treated aqueous xanthan solutions in the semidilute concentration regime 显示文摘 | OVIATT H W BRANT D A | 1994 | Macromolecules1994，27，： | 1 |
| 7 | A spectrophotometric method for detecting blood in white-shell eggs显示文摘 | Brant A W Norris K H Chin G | 1953 | Poultry Scienc1953，32，2： | 1 |
| 8 | 显示文摘 | Brant J Lecoanet H Wiesner M R | 2005 | J Nanopart Res2005，7，12： | 1 |
| 9 | Intake of conjugated linoleic acid,fat,and other fatty acids in relation to postmenopausal breast cancer:the Netherlands cohort study on diet and cancer显示文摘 | VOORRIPS L E BRANTS H A KARDINAAL A F M | 2002 | Am J Clin Nutr2002，76，4： | 1 |
| 10 | Maternal mood and neuroendocrine programming:effects of time of exposure and sex显示文摘 | Vedhara K Metcalfe C Brant H | 2012 | J Neuroendocrinol2012，24，： | 1 |
| 11 | Aggregation and deposition characteristics of fullerene nanoparticles in aqueous systems显示文摘 | Brant J Lecoanet H Wiesner MR | 2005 | J NanopartRes2005，4，5： | 1 |
| 12 | Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality:an epidemiological investigation in a cohort of 163,944 Austrian adults显示文摘 | Ruttmann E Brant LJ Concin H | 2005 | Circulation2005，112，14： | 1 |
| 13 | Gamma - glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163944 Austrianadults 显示文摘 | Ruttmann E Brant LJ Concin H | 2005 | Circulation2005，112，14： | 1 |
| 14 | Gamma- glu- tamyltransferase as a risk factor for cardiovascular disease mor- tality:an epidemiological investigation in a cohort of 163,944 Austrian adults显示文摘 | RUTrMANN E BRANT L J CONCIN H | 2005 | Circulation2005，112，14： | 1 |
| 15 | A prospective cohort study on antioxidant and folate intake and male lung cancer risk 显示文摘 | Voorrips L E Goldbohm R A Brants H A M | 2000 | Cancer Epidemiol Biomarkers Prev2000，9，4： | 1 |
| 16 | In- take of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer, the Netherlands Cohort Study on Diet and Cancer显示文摘 | Voorrips L E Brants H A Kardinaal A F | 2002 | Am J Clin Nutr2002，76，4： | 1 |
| 17 | Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163, 944 Austrian adults显示文摘 | Ruttmann E Brant L J Concin H | 2005 | Circulation2005，112，14： | 1 |
| 18 | Dielectric parameters relevant to microwave dielectric heating显示文摘 | Gabriel C Gabriel S Brant E H | 1998 | Chemical Society Review1998，27，： | 1 |
| 19 | Effects of supplementation on voluntary forage intake, diet digestibility, and animal performance 显示文摘 | MOORE J E BRANT M H KUNKLE W E | 1999 | Journal of Animal Scienge1999，77，2： | 1 |
| 20 | Plant sterol intakes and colorectal cancer risk in the Netherlands cohort study on diet and cancer显示文摘 | Normen A L Brants H A M Voorrips L E | 2001 | Am J Clin Nutr2001，74，： | 1 |
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