|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Quantitative Study on Nonmetallic Inclusion Particles in Steels by Automatic Image Analysis With Extreme Values Method显示文摘The presence of nonmetallic inclusion particles which appear during steelmaking process is harmful to the properties of steels,which is mainly as a function of some aspects such as size,volume fraction,shape,and distribution of these particles.The automatic image analysis technique is one of the most important tools for the quantitative determination of these parameters.The classical Student approach and the Extreme Values Method(EVM) were used for the inclusion size and shape determination and the evaluation of distance between the inclusion particles.The results thus obtained indicated that there were significant differences in the characteristics of the inclusion particles in the analyzed products.Both methods achieved results with some differences,indicating that EVM could be used as a faster and more reliable statistical methodology. | Cássio Barbosa José Brant de Campos Jneo Lopes do Nascimento Iêda Maria Vieira Caminha | 2009 | Journal of Iron and Steel Research(International)2009，16，4： | 7 |
| 3 | 显示文摘 | Nelson J A Brant E L Wagner M J | 2003 | Chem Mater2003，15，： | 1 |
| 4 | Microbial community utilization of added carbon substrates in response to long-term carbon input manipulation显示文摘 | Brant J B Sulzman E W Myrold D D | 2006 | Soil Biology and Biochemistry2006，38，8： | 1 |
| 5 | Evolutionary origins,diversification,and biogeography of liver flukes(Digenea,Fasciolidae)显示文摘 | LOTFY W M BRANT S V DEJONG R J | 2008 | Am J Trop Med Hyg2008，79，2： | 1 |
| 6 | Silver Staining of DNA in Polyacrylamide Gels 显示文摘 | Brant J Bassam Gustavo Caetano Anolle | 1993 | Applied Biochemistry and Biotechnology1993，42，： | 1 |
| 7 | Gamma glutamyltransferase as a risk factor for cardiovascular disease mortality:an epidemiological investigation in a cohort of 163,944 Austrian adults显示文摘 | Ruttmann E Brant L J Conein H Diem G Rapp K Ulmer H | 2005 | Circulation2005，112，： | 1 |
| 8 | Comparison of the a- bilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradign 显示文摘 | Xia T Kovochich M Brant J | 2006 | Nano Letters2006，6，8： | 1 |
| 9 | T-shaped shunt and intracavernous tunneling for prolonged ischemic priapism 显示文摘 | Brant WO Garcia MM Bella A J | 2009 | J Urol2009，181，： | 1 |
| 10 | Sulfur hexafluoride and the electric power industry显示文摘 | Christophorou L G OlthoffJ K Van Brant R J | 1997 | IEEE Transactions on Electrical Insulation1997，13，5： | 1 |
| 11 | Microbial community utilization of added carbon substrates in re- sponse to long-term carbon input manipulation 显示文摘 | BRANT J B SUIZMAN E W MYROLD D D | | Soil Bidogy and Biochemistry0，38，8： | 1 |
| 12 | Treatment options for erectile dysfunction显示文摘 | Brant W O Bella A J Lue T L | 2007 | End Metab Clin N AM2007，26，： | 1 |
| 13 | In vivo quantitative proton MRSI study of brain development from childhood to adolescence 显示文摘 | Horska A Kaufmann W E Brant L J | 2002 | J Magn Reson Imaging2002，15，2： | 1 |
| 14 | γ-Glutamyl-transferase as a Risk Factor for Cardiovascular Disease Mortality显示文摘 | Elfriede Rutmann Larry J Brant Hans Concin | | 0，，： | 1 |
| 15 | Age changes in pure tone hearing thresholds in a long longitudinal study of normal human aging显示文摘 | Brant L Fozard J | 1990 | J Aeoust Soc Am1990，88，： | 1 |
| 16 | Comparison of the abilities of ambient and manufactured nano- particles to induce cellular toxicity according to an oxidative stress paradigm显示文摘 | Xia T Kovochich M Brant J Hotze M Sempf J Oberley T | 2006 | Nano Lett2006，6，： | 1 |
| 17 | Serum uric acid is an in- dependent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21 -- year follow-- up study 显示文摘 | Strasak A M Kelleher C C Brant L J | 2008 | Int J Cardiol2008，125，2： | 1 |
| 18 | 显示文摘 | Brant J Lecoanet H Wiesner M R | 2005 | J Nanopart Res2005，7，12： | 1 |
| 19 | Hormone replacement thera-py and longitudinal changes in blood pressure in postmenopausal women显示文摘 | Scuteri A Bos A J Brant LJ | 2001 | Ann Intern Meal2001，135，4： | 1 |
| 20 | Hormone replacement therapy and longitudinal changes in blood pressure in postmenopausal women显示文摘 | Scuteri A Bos A J Brant L J | 2001 | Ann Intern Med2001，135，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员