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| 1 | Engineering Non-transgenic Gynoecious Cucumber Using an Improved Transformation Protocol and Optimized CRISPR/Cas9 System显示文摘 | Bowen Hu Dawei Li Xin Liu Jingjing Qi Dongli Gao Shuqiao Zhao Sanwen Huang Jinjing Sun Li Yang | 2017 | Molecular Plant2017，10，12： | 25 |
| 2 | Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines显示文摘单性生殖的胚胎的茎(足) 细胞为学习位于印的 genomic 下面的分子的机制提供一个珍贵试管内模型系统。然而,足房间的 thepluripotency 和父亲一般地表示的印的基因的表示侧面一直不是充分探索了。在这研究,三根老鼠足房间线被建立,在扩大文化的这些房间的区别潜力被评估。无差别的房间有正常核型和同型结合的染色体,并且表示了 ES-cell-specific 分子的标记。房间在超过 50 个段落以后仍然保持无差别并且展出了 pluripotentdifferentiation 能力。确定的 ES 房间的所有三根线生产了 teratomas;ES 房间的二根线生产了怪物和细菌线传播。而且,在这些房间的父亲一般地表示的印的基因 Snrpn, U2af1-rs1, Peg3,影响, Zfp127, Dlk1 和 Mest 的激活被检测。父亲一般地表示的印的基因被发现在单性生殖的联盟者的胚囊阶段被表示的一些激活胚胎试管内,他们的表示水平与扩大的足细胞培养增加了。而且,我们在足房间的这些父亲一般地表示的印的基因的激活在 ther 的甲基化与一个变化被联系的数据表演鼓舞了差别 methylated 区域。这些调查结果为足房间的 thepluripotency 提供直接证据并且在足房间表明在脱氧核糖核酸甲基化模式和父亲一般地表示的印的基因的激活之间的协会。因此,确定的 ES 房间线为在哺乳动物的开发学习 epigenetic 规定提供一个珍贵模型。 | Hua Jiang Bowen Sun Weicheng Wang Zhihong Zhang Furong Gao Guilai Shi Bing Cui XiangyinKong Zhao He Xiaoyan Ding Ying Kuang Jian Fei Yi Juan Sun Yun Feng Ying Jin | 2007 | Cell Research2007，17，9： | 10 |
| 3 | Heat Transfer Characteristics of Boiler Convective Heating Surface Under Pressurized Oxygen-fuel Combustion Conditions显示文摘增压富氧燃烧是一项极具前景的减排CO2新技术。对增压富氧燃烧条件下,对流受热面换热特性进行研究具有重要的意义。该文以一台实际300MW等级机组煤粉锅炉为计算对象,采用维里方程及Chun等的计算方法计算确定增压富氧燃烧烟气物性,采用宽带关联k模型计算富氧燃烧烟气辐射特性。进行了常规空气燃烧以及φ(O2):φ(CO2)=21:79、φ(O2):φ(CO2)=30:70两种比例的0.1、0.5、1.0、1.5、6 MPa五种压力下增压富氧燃烧各对流受热面的热力计算,分析了增压富氧燃烧条件烟气压力变化对各受热面换热特性的影响。研究结果表明:随烟气压力的升高,烟气流速下降,但烟气的Re却基本保持不变,对流换热系数有所增加。增压富氧燃烧烟气的辐射换热系数比空气燃烧烟气辐射换热系数大。实现同样的换热量,增压富氧燃烧条件下(φ(O2):φ(CO2)=21:79、φ(O2):φ(CO2)=30:70)对流受热面所需换热面积比常规空气燃烧条件下少。 | Gao Zhengyang Xia Ruiqing Yan Weiping Ma Kai Feng Wenhui Zhang Bowen | 2012 | 中国电机工程学报2012，32，23： | 8 |
| 4 | Inverse design of low boom configurations using proper orthogonal decomposition and augmented Burgers equation显示文摘Mitigation of sonic boom to an acceptable stage is a key point for the next generation of supersonic transports. Meanwhile, designing a supersonic aircraft with an ideal ground signature is always the focus of research on sonic boom reduction. This paper presents an inverse design approach to optimize the near-field signature of an aircraft, making it close to the shaped ideal ground signature after the propagation in the atmosphere. Using the Proper Orthogonal Decomposition(POD) method, a guessed input of augmented Burgers equation is inversely achieved. By multiple POD iterations, the guessed ground signatures successively approach the target ground signature until the convergence criteria is reached. Finally, the corresponding equivalent area distribution is calculated from the optimal near-field signature through the classical Whitham F-function theory. To validate this method, an optimization example of Lockheed Martin 1021 is demonstrated. The modified configuration has a fully shaped ground signature and achieves a drop of perceived loudness by 7.94 PLdB. This improvement is achieved via shaping the original near-field signature into wiggles and damping it by atmospheric attenuation. At last, a nonphysical ground signature is set as the target to test the robustness of this inverse design method and shows that this method is robust enough for various inputs. | Yidian ZHANG Jiangtao HUANG Zhenghong GAO Chao WANG Bowen SHU | 2019 | Chinese Journal of Aeronautics2019，32，6： | 7 |
| 5 | High-performance all-solid-state polymer electrolyte with fast conductivity pathway formed by hierarchical structure polyamide 6 nanofiber for lithium metal battery显示文摘The utilization of all-solid-state electrolytes is considered to be an effective way to enhance the safety performance of lithium metal batteries.However,the low ionic conductivity and poor interface compatibility greatly restrict the development of all-solid-state battery.In this study,a composite electrolyte combining the electrospun polyamide 6(PA6)nanofiber membrane with hierarchical structure and the polyethylene oxide(PEO)polymer is investigated.The introduction of PA6 nanofiber membrane can effectively reduce the crystallinity of the polymer,so that the ionic conductivity of the electrolyte can be enhanced.Moreover,it is found that the presence of finely branched fibers in the hierarchical structure PA6 membrane allows the polar functional groups(C=O and N-H bonds)to be fully exposed,which provides sufficient functional sites for lithium ion transport and helps to regulate the uniform deposition of lithium metal.Moreover,the hierarchical structure can enhance the mechanical strength(9.2 MPa)of the electrolyte,thereby effectively improving the safety and cycle stability of the battery.The prepared Li/Li symmetric battery can be stably cycled for 1500 h under 0.3 mA cm^(-2) and 60℃.This study demonstrates that the prepared electrolyte has excellent application prospects in the next generation all-solid-state lithium metal batteries. | Lu Gao Jianxin Li Jingge Ju Bowen Cheng Weimin Kang Nanping Deng | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 6 | Mutation in a novel gene SMALL AND CORDATELEAF 1 affects leaf morphology in cucumber显示文摘Plant species exhibit substantial variation in leaf morphology.VWe isolated a recessive mutant gene termed small and cordate leaf 1(sclh)that causes alteration in both leaf size and shape of cucumber.Compared to wild type leaves,the sclh mutant had fewer numbers of epidermal pavement cells.A single nucleotide polymorphism was associated with this leaf phenotype,which occurred in a putative nucleoside bisphosphate phosphatase.RNA-seq analysis of the wild type and sclh mutant leaves suggested that SCL_1 regulation may not involve known hormonal pathways.Our work identified a candidate gene for SCL_1 that may play a role in leaf development. | Dongli Gao Chunzhi Zhang Shu Zhang Bowen Hu Shenhao Wang Zhonghua Zhang Sanwen Huang | 2017 | Journal of Integrative Plant Biology2017，59，10： | 3 |
| 7 | A new long-side-chain sulfonated poly(2,6-dimethyl-1,4-phenylene oxide)(PPO)/polybenzimidazole(PBI)amphoteric membrane for vanadium redox flow battery显示文摘A new amphoteric membrane was prepared by blending long-side-chain sulfonated poly(2,6-dimethyl-1,4-phenylene oxide)(S-L-PPO)and polybenzimidazole(PBI)for vanadium redox flow battery(VRFB)application.An acid-base pair structure formed between the imidazole of PBI and sulfonic acid of S-L-PPO resulted in lowered swelling ratio.It favors to reduce the vanadium permeation.While,the increased sulfonic acid concentration ensured that proton conductivity was still at a high level.As a result,a better balance between the vanadium ion permeation(6.1×10^-9 cm^2·s^-1)and proton conductivity(50.8 m S·cm^-1)in the S-L-PPO/PBI-10%membrane was achieved.The VRFB performance with S-L-PPO/PBI-10%membrane exhibited an EE of 82.7%,which was higher than those of pristine S-L-PPO(81.8%)and Nafion 212(78.0%)at 120 m A·cm^-2.In addition,the S-LPPO/PBI-10%membrane had a much longer self-discharge duration time(142 h)than that of Nafion 212(23 h). | Bowen Jiang Lei Hu Xiaoming Yan Jiahui Sun Li Gao Yan Dai Xuehua Ruan Gaohong He | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 3 |
| 8 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 9 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 10 | Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following C02 pneumoperitoneum in rats显示文摘 | Xingwei Xu Xin Gao Peng Zheng Tao Feng Bowen Ding Xiaoming Kao Wu Ji Ning Li Jieshou Li | 2014 | Clinical and Investigative Medicine (Online)2014，，3： | 1 |
| 11 | Stereo hidden Markov modeling for noise robust speech recognition 显示文摘 | Xiaodong Cui Mohamed Afify Yuqing Gao Bowen Zhou | 2013 | Computer Speech and Language2013，27，： | 1 |
| 12 | 显示文摘 | Gao Yan Wang Bowen | 2001 | Appl Phys Lett2001，78，： | 1 |
| 13 | Optimized CeO_(2) Nanowires with Rich Surface Oxygen Vacancies Enable Fast Li-Ion Conduction in Composite Polymer Electrolytes显示文摘Low-cost and flexible solid polymer electrolytes are promising in all-solid-state Li-metal batteries with high energy density and safety.However,both the low room-temperature ionic conductivities and the small Li^(+)transference number of these electrolytes significantly increase the internal resistance and overpotential of the battery.Here,we introduce Gd-doped CeO_(2) nanowires with large surface area and rich surface oxygen vacancies to the polymer electrolyte to increase the interaction between Gd-doped CeO_(2) nanowires and polymer electrolytes,which promotes the Li-salt dissociation and increases the concentration of mobile Li ions in the composite polymer electrolytes.The optimized composite polymer electrolyte has a high Li-ion conductivity of 5×10^(-4)4 S cm^(-1) at 30℃ and a large Li+transference number of 0.47.Moreover,the composite polymer electrolytes have excellent compatibility with the metallic lithium anode and high-voltage LiNi_(0.8)Mn _(0.1)Co_(0.1)O_(2)(NMC)cathode,providing the stable cycling of all-solid-state batteries at high current densities. | Lu Gao Nan Wu Nanping Deng Zhenchao Li Jianxin Li Yong Che Bowen Cheng Weimin Kang Ruiping Liu Yutao Li | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 14 | 显示文摘 | Gao Yan Wang Bowen | 2001 | Appl Phys Lett2001，78，： | 1 |
| 15 | Stereo hidden Markov modeling for noise robust speech recognition显示文摘 | Xiaodong Cui Mohamed Afify Yuqing Gao Bowen Zhou | 2013 | Computer Speech & Language2013，，2： | 1 |
| 16 | Spectroscopic studies on the excited state properties of the light-induced antiviral drug hypocrellin A loaded in the mesoporous solid显示文摘 | Lei Z Zhang Guoqing Tang Bowen Gao | 2004 | Chem Phys Lett2004，396，： | 1 |
| 17 | Mg-based inorganic nanofibers constructing fast and multi-dimensional ion conductive pathways for all-solid-state lithium metal batteries显示文摘Solid-state electrolytes(SSEs),which replace flammable and toxic liquid electrolytes,have attracted widely attention.However,there exist still some challenges in actual application such as poor interfacial compatibility and slow ionic migration.In this study,Mg O nanofibers and MgF;nanofibers were prepared via the electro-blow spinning and high-temperature calcination methods,and were applied to all-solid-state lithium metal batteries for the first time.The organic-inorganic composite SSEs exhibited continuous conduction paths based on the virtue of the nanofibers with high length-to-diameter ratio,which were designed and prepared by mixing prepared fillers into the poly(ethylene oxide)(PEO)/lithium bis(trifluoromethane)sulfonilimide(Li TFSI)system.The effect of filler with different morphologies,doping ratios and component on ionic conductivity,electrochemical stability and cycle performance were explored under two kinds of[EO]/[Li^(+)]ratios and ambient temperatures.The ionic conductivities of electrolytes containing Mg O and MgF;nanofibers can reach up to 1.19×10^(-4) and 1.39×10^(-4) S cm^(-1) at 30℃,respectively.They were attributed to specific ionic conductive enhancement at the organicinorganic interface,reduced crystallinity and Lewis acid interaction,which can effectively promote the dissociation of the lithium salts.Especially MgF_(2) nanofiber,combining low electronic conductance,excellent electrochemical stability and outstanding inhibition for lithium dendrites of fluorides,endowed the battery with an initial specific capacity of 140.6 m Ah g^(-1) and capacity decay rate per cycle of 0.055%after500 cycles at 50℃.The work can provide an idea to design SSE with fast and multi-dimensional Li conductive paths and excellent interfacial compatibility. | Wen Yu Nanping Deng Zirui Yan Lu Gao Kewei Cheng Xiaohui Tian Lin Tang Bowen Cheng Weimin Kang | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 18 | 显示文摘 | Hao Yanming Gao Yan Wang Bowen | 2001 | Appl Phys Lett2001，78，： | 1 |
| 19 | Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases显示文摘Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene expression.As one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and metabolism.Mechanistically,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or lncRNAs.Here,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic diseases.We discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of H19.Ultimately,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. | Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，4： | 1 |
| 20 | WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation显示文摘导致 Oncogene 的老朽(OIS ) 或通过 DNA 损坏反应的 apoptosis 是 tumorigenesis 的一个重要障碍。克服这个障碍导致反常房间增长, genomic 不稳定性,和细胞的转变,并且最后允许癌症发展。然而, OIS 障碍怎么被克服,仍然保持不清楚。这里,我们证明 E3 ubiquitin ligase WD 重复并且 SOCS 包含盒子的蛋白质(WSB1 ) 1 在克服 OIS 起一个作用。在主要房间的 WSB1 表示帮助 OIS 的 bypass,导致反常增长和细胞的转变。机械学地, WSB1 支持 ATM ubiquitination,导致从 OIS 的 ATM 降级和逃跑。而且,我们作为 WSB1 的在上游的 kinase 识别 CDK。调停 CDK 的 phosphorylation 由支持它的 monomerization 激活 WSB1。在人的癌症织物并且在 vitro 模型,导致 WSB1 的 ATM 降级在 tumorigenic 前进期间是一个早事件。我们建议 WSB1 是通过 ATM 降级和 tumorigenesis 障碍的破坏的早 oncogenic 事件的关键播放器之一。我们的工作在 premalignant 损害建立癌症开发和前进的重要机制。 | Jung Jin Kim Seung Baek Lee Sang-Yeop Yi Sang-Ah Han Sun-Hyun Kim Jong-Min Lee Seo-Yun Tong Ping Yin Bowen Gao Jun Zhang Zhenkun Lou | 2017 | Cell Research2017，27，2： | 1 |
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