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| 1 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 2 | Roles of metal element substitutions from the bimetallic solid state electrolytes in lithium batteries显示文摘All-solid-state lithium batteries(ASSLBs),receiving extensive attentions and studies,exhibit better safety,environmental friendliness,stability,wider electrochemical stability window and higher energy density than traditionally liquid lithium batteries.In a variety of inorganic materials,with highly replaceable,the non-lithium metal elements emerge in endlessly and affect performances in diversiform ways.Due to facile preparation,convertible structures and excellent properties,the lithium-containing bimetallic granular materials are often applied as important components of electrolytes in lithium batteries.In this review,in terms of the properties of substituted elements,changing crystal structures,increasing vacancies or defects and improving the interfacial conductions,the roles of metal element substitutions of inorganic particles on the improvement of solid-state electrolytes are expounded.And the applications of substituted strategies in ASSLBs as the host of inorganic particles electrolytes and as fillers or modifications for composite electrolytes are also investigated and discussed.It also summarizes the current concerns and obstacles that need to be broken through,as well as provides a basis guide for the selection and optimization of inorganic particles. | Wen Yu Nanping Deng Lin Tang Kewei Cheng Bowen Cheng Weimin Kang | 2022 | Particuology2022，20，6： | 2 |
| 3 | Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531显示文摘 | Litao Yang Aihu Pan Kewei Zhang Changsong Yin Bingjun Qian Jianxiu Chen Cheng Huang Dabing Zhang | 2005 | Transgenic Research2005，，6： | 1 |
| 4 | Power-to-Hydrogen by Electrolysis in Carbon Neutrality: Technology Overview and Future Development显示文摘Power-to-hydrogen by electrolysis(PtHE)is a promising technology in the carbon-neutral evolution of energy.PtHE not only contributes to renewable energy integration but also accelerates decarbonization in industrial sectors through green hydrogen production.This paper presents a comprehensive review of PtHE technology.First,technical solutions in PtHE technology are introduced to clarify pros and cons of one another.Besides,the multiphysics coupling and the multi-energy flow are investigated to reveal the insight mechanism during operation of compactly assembled industrial PtHE plants.Then,the development trends of core components in PtHE plants,including electrocatalysts,electrode plates and operation strategy,are reviewed,respectively.Research thrusts needed for PtHE in carbon-neutral transition are also summarized.Finally,three configurations of the PtHE plant in energy system integration are introduced,which can achieve renewable energy integration and efficient energy utilization.Index Terms-Carbon neutrality,power-to-hydrogen nby electrolysis(PtHE),multiphysics coupling,multidisciplinary. | Zhiyao Zhong Jiakun Fang Kewei Hu Danji Huang Xiaomeng Ai Xiaobo Yang Jinyu Wen Yuan Pan Shijie Cheng | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 1 |
| 5 | A numerical investigation of blow-up in reactiomdiffusion problems with traveling heat sources显示文摘 | Zhu Hancan Liang Kewei Cheng Xiaoliang | 2010 | Journal of Computational and Applied Mathematics2010，234，： | 1 |
| 6 | Gold hull and internode encodes a primarily multifunctional cinnamyl-alcohol dehydrogenase in rice 显示文摘 | Zhang Kewei Qian Qian Huang Zejun Wang Yiqin Li Ming Cheng Zhukuan | 2006 | Plant Physiology2006，104，3： | 1 |
| 7 | Mg-based inorganic nanofibers constructing fast and multi-dimensional ion conductive pathways for all-solid-state lithium metal batteries显示文摘Solid-state electrolytes(SSEs),which replace flammable and toxic liquid electrolytes,have attracted widely attention.However,there exist still some challenges in actual application such as poor interfacial compatibility and slow ionic migration.In this study,Mg O nanofibers and MgF;nanofibers were prepared via the electro-blow spinning and high-temperature calcination methods,and were applied to all-solid-state lithium metal batteries for the first time.The organic-inorganic composite SSEs exhibited continuous conduction paths based on the virtue of the nanofibers with high length-to-diameter ratio,which were designed and prepared by mixing prepared fillers into the poly(ethylene oxide)(PEO)/lithium bis(trifluoromethane)sulfonilimide(Li TFSI)system.The effect of filler with different morphologies,doping ratios and component on ionic conductivity,electrochemical stability and cycle performance were explored under two kinds of[EO]/[Li^(+)]ratios and ambient temperatures.The ionic conductivities of electrolytes containing Mg O and MgF;nanofibers can reach up to 1.19×10^(-4) and 1.39×10^(-4) S cm^(-1) at 30℃,respectively.They were attributed to specific ionic conductive enhancement at the organicinorganic interface,reduced crystallinity and Lewis acid interaction,which can effectively promote the dissociation of the lithium salts.Especially MgF_(2) nanofiber,combining low electronic conductance,excellent electrochemical stability and outstanding inhibition for lithium dendrites of fluorides,endowed the battery with an initial specific capacity of 140.6 m Ah g^(-1) and capacity decay rate per cycle of 0.055%after500 cycles at 50℃.The work can provide an idea to design SSE with fast and multi-dimensional Li conductive paths and excellent interfacial compatibility. | Wen Yu Nanping Deng Zirui Yan Lu Gao Kewei Cheng Xiaohui Tian Lin Tang Bowen Cheng Weimin Kang | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 8 | Response of the xenograft endothelium in the concordant xenotransplantation显示文摘Objective: To investigate the response of the xenograft endothelium in the concordant hamster to rat cardiac xenotransplantation and the mechanism of acute vascular rejection. Methods: The animals were divided into 5 groups randomly: control group, CsA group, splenectomy group, D0 splenectomy+CsA group and D3 splenectomy+CsA group. Hamster heart was heterotopicaly transplanted to rat abdominal cavity. The graft survival was monitored by palpation of the rat abdominal wall. The histological and ultrastructural changes of the xenogafts were investigated. NF-κB and P-selectin expression in the xenograft were detected. Heme Oxigenase-1 and Bcl-2 expression were also detected in the xenografts of different groups. Results: The mean survival time of the xenografts in control group,CsA group, splenectomy group, D0 splenectomy+CsA group and D3 splenectomy+CsA group was 3.4 ± 0.55, 3.8 ± 0.45, 6.4 ± 1.52, 30 and 7.4 ± 1.14 days. The rejected graft showed typical acute vascular rejection in control group, CsA group,splenectomy group and D3 splenectomy+CsA group. Endothelial cells of the rejected xenograft showed dramatic assembly of ribosomes and expansion of the rough endoplasmic reticulum. However, the endothelium of the long-term survived grafts in D0 splenectomy+CsA group showed normal architecture. NF-κB and P-selectin expression were detected in the rejected xenografts. HO-1 expression was observed in the long-term survived xenografts in D0 splenectomy+CsA group. Conclusion: The endothelial cells of the xenograft might be activated during the acute vascular rejection. Expression of HO-1 might inhibit the upregulation of NF-κB and adhesion molecular which decreases the activation of the endothelium of the graft. | Bo Wang Yi Lu Cheng' en Pan Xiaogang Zhang Hui Li Kewei Meng ZhengWu | 2007 | Journal of Nanjing Medical University2007，21，1： | 1 |
| 9 | Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531显示文摘 | Litao Yang Aihu Pan Kewei Zhang Changsong Yin Bingjun Qian Jianxiu Chen Cheng Huang Dabing Zhang | 2005 | Transgenic Research2005，，6： | 1 |
| 10 | Synthesis and formation mechanism of HfB_(2) ultrafine powders with low oxygen via flocculating settling assisted process and carbo/borothermal reduction显示文摘In this study,ultrafine HfB_(2) powders with low oxygen were synthesized by a flocculating settling process which yielded ceramic precursors and subsequent carbo/borothermal reduction of the precursors.The liquid phase precursor method can achieve uniform mixing of components at the molecular level through multiple complexation reactions,and then realize the carbo/borothermal reduction reaction at a lower temperature to obtain ultrapure HfB2 powders.The as-resulted quasi-spherical HfB2 powders under the optimum conditions(atomic molar ratio M:B:C=1:2.8:10)calcined at 1500°C for 1 h have an average particle size of 205 nm and an oxygen content of 0.097 wt.%.Detailed analysis of the phase evolution of precursors shows that the formation of HfB2 particles is a mass diffusion mode from the external to internal HfO_(2)cores.We reveal that below 1300°C,HfC is not an intermediate product of HfB2 powder during the transition of precursors.Instead,HfC was formed as a by-product at high temperatures in the carbo/borothermal reduction process.The proposed formation mechanism of HfB_(2) is completely different from the traditional two-step transformation method.After the sintering of the ultrafine powders,the HfB_(2) ceramics show a relative density of 96.1%and superior mechanical properties compared to other works.Furthermore,by simply replacing the initial metal source,chlorinated group IV and V transitional metals(Ti,Zr,Ta,Nb)can also convert into high-purity and ultrafine diborides.This work shows that flocculating settling assisted carbo/borothermal reduction has potential in lot size production of various high-purity and ultrafine boride powders. | Zhen Wang Yuan Cheng Kewei Li Tianxu Wang Mengen Hu Chunxue Zheng Xinyang Li Zhulin Huang Xiaoye Hu Yue Li Xinghong Zhang | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 11 | Prevalence and molecular epidemiology of equine piroplasmosis in China:a neglected tick-borne disease显示文摘Dear Editor,Equine piroplasmosis(EP)is an infectious,tick-borne dis-ease caused by the hemoprotozoan parasites Theileria equi(T.equi)and Babesia caballi(B.caballi).EP affects all wild and domestic equids,and clinical presentation is related to intravascular hemolysis and associated systemic illness(Scoles and Ueti,2015).This disease has considerable ve-terinary and economic impact on the equine industry worldwide,and is listed as a reportable disease by the World Organization for Animal Health(OIE).Importantly,a ne-gative EP test is mandatory for animals participating in equestrian sports and the horse trade.It is estimated that 90%of the global horse population resides in EP-endemic areas.Many risk factors are associated with the infection rate,in-cluding animal species,age,gender,breed,activities,and environmental factors(Onyiche et al.,2019). | Kewei Chen Zhe Hu Jingkun Li Jingfei Wang Diqiu Liu Ting Qi Wei Guo Cheng Du Xiaojun Wang | 2022 | Science China(Life Sciences)2022，65，2： | 0 |
| 12 | Advances in preparation methods and mechanism analysis of layered double hydroxide for lithium-ion batteries and lithium-sulfur batteries显示文摘Lithium-ion(Li-ion) battery and lithium-sulfur(Li-S) battery have attracted significant attention as promising components for large-scale energy storage because of high theoretical capacity of Li,excellent energy density or environmental friendness for two kinds of batteries.However,there still exist some respective obstacles for commercial applications,such as limited theoretical capacity,high cost and low conductivity of Li-ion cells or shuttle effect of lithium polysulfides of Li-S cells.As typical twodimensional materials,layered double hydroxides(LDHs) exhibit excellent potential in the field of energy storage due to facile tunability of composition,structure and morphology as well as convenient composite and strong catalytic properties.Consequently,various LDHs toward novel separators or interlayers,cathodes,anodes,and interesting catalytic templates are researched to resolve these challenges.In this review,the recent progress for LDHs applied in Li-ion batteries and Li-S batteries including the synthesis methods,designs and applications is presented and reviewed.Meanwhile,the existing challenges and future perspectives associated with material designs and practical applications of LDHs for these two classes of cells are discussed.WeWe hope that the review can attract more attention and inspire more profound researches toward the LDH-based electrochemical materials for energy storage. | Wen Yu Nanping Deng Kewei Cheng Jing Yan Bowen Cheng Weimin Kang | 2021 | Journal of Energy Chemistry2021，30，7： | 0 |
| 13 | The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis显示文摘Osteoarthritis(OA)is a degenerative or posttraumatic condition of the joints.In OA chondrocytes,Nrf2 functions as a stress response regulator with antioxidant and anti-inflammatory effects.This study aims to investigate the role of Nrf2 and its downstream pathway in the development of osteoarthritis.IL-1βtreatment suppresses Nrf2,aggrecan,and COL2A1 levels and cell viability but promotes apoptosis in chondrocytes.IL-1βstimulation induces cell apoptosis,upregulates the mRNA expression of inflammatory factors,decreases aggrecan,COL2A1,and Bcl-2 levels but increases ADAMTS-5,ADAMTS-4,MMP13,cleaved caspase 3,and BAX levels,and promotes p65 phosphorylation.Nrf2 overexpression exerts opposite effects on IL-1β-treated chondrocytes,as demonstrated by the significant attenuation of IL-1β-induced changes in chondrocytes.By binding to the HMGB1 promoter region,Nrf2 suppresses HMGB1 expression.Similar to Nrf2 overexpression,HMGB1 knockdown also attenuates IL-1β-induced changes in chondrocytes.Notably,under IL-1βstimulation,the effects of Nrf2 overexpression or tertbutylhydroquinone(TBHQ,an activator of Nrf2)on apoptosis,inflammatory factor expression,ECM and apoptosis,and NF-κB pathway activity in chondrocytes are remarkably reversed by HMGB1 overexpression or recombinant HMGB1(rHMGB1).Similarly,rHMGB1 could partially counteract the curative effect of TBHQ on OA damage in mice.In OA cartilage tissue samples,the level of Nrf2 is lower,while the levels of HMGB1,apoptotic,and inflammatory factors are increased compared to normal cartilage tissue samples.In conclusion,for the first time,the Nrf2/HMGB1 axis was found to modulate apoptosis,ECM degradation,inflammation and activation of NF-κB signaling in chondrocytes and OA mice. | Wenzhao Li Cheng Tao Minzhi Mao Kewei Zhu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
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