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| 1 | Transcranial Doppler ultrasonography: From methodology to major clinical applications显示文摘Non-invasive Doppler ultrasonographic study of cerebral arteries [transcranial Doppler(TCD)] has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency(≤ 2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays the most widespread indication for TCD in outpatient setting is the research of right to left shunting, responsable of so called 'paradoxical embolism', most often due to patency of foramen ovale which is responsable of the majority of cryptogenic strokes occuring in patients younger than 55 years old. TCD also allows to classify the grade of severity of such shunts using the so called 'microembolic signal grading score'. In addition TCD has found many useful applications in neurocritical care practice. It is useful on both adults and children for day-to-day bedside assessment of critical conditions including vasospasm in subarachnoidal haemorrhage(caused by aneurysm rupture or traumatic injury), traumatic brain injury, brain stem death. It is used also to evaluate cerebral hemodynamic changes after stroke. It also allows to investigate cerebral pressure autoregulation and for the clinical evaluation of cerebral autoregulatory reserve. | Antonello D'Andrea Marianna Conte Massimo Cavallaro Raffaella Scarafile Lucia Riegler Rosangela Cocchia Enrica Pezzullo Andreina Carbone Francesco Natale Giuseppe Santoro Pio Caso Maria Giovanna Russo Eduardo Bossone Raffaele Calabrò | 2016 | World Journal of Cardiology2016，8，7： | 10 |
| 2 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 3 | Heart and lung, a dangerous liaison-Tako-tsubo cardiomyopathy and respiratory diseases: A systematic review显示文摘AIM: To investigate the possible association between Tako-tsubo cardiomyopathy(TTC)-a reversible clini-cal condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mecha-nisms- and respiratory system diseases. METHODS: We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to ar-ticles in English. The search keywords were: 'tako-tsubo cardiomyopathy', 'takotsubo', 'takotsubo cardiomyopa-thy', 'broken heart syndrome', 'stress-induced cardio-myopathy', 'apical ballooning syndrome', and 'ampulla cardiomyopathy in combination with respiratory dis-eases, lung, pulmonary disease. For each kind of dis-ease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome. RESULTS: Out of a total of 1725 articles found, we se-lected 37 papers reporting a total of 38 patients. As ex-pected, most patients were women(81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged un-eventfully in a few days. CONCLUSION: An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC. | Roberto Manfredini Fabio Fabbian Alfredo De Giorgi Marco Pala Alessandra Mallozzi Menegatti Claudia Parisi Elisa Misurati Ruana Tiseo Massimo Gallerani Raffaella Salmi Eduardo Bossone | 2014 | World Journal of Cardiology2014，6，5： | 3 |
| 4 | 水流程的分析:瑞典一个潜在地质埋藏点的研究方法和计算实例显示文摘与深处于基岩中的核废料地质埋藏点的选址有关的安全评估需要确定潜在的流程及起源于埋藏点深度的放射性核素的相关传播时间。利用瑞典Laxemar候选场所作为案例研究,本文描述了模拟方法、数据集成以及由此而产生的水流模型,重点放在第四纪沉积物和基岩的上部150m。实例模拟确定了到地下水排泄区的流程以及表层系统中的流程。大多数模拟的地下水流程都终止于主要的表层水域和海岸线,即便用于跟踪流径的颗粒是以一种在相对较浅深度的均匀的空间分布输入的。计算出来的决定放射性核素衰减和持留可用的时间的地下水到沿岸海湾的行进时间要长于到该场所其他生物圈目标的。此外,基于GIS的模拟如何能用于限制安全评估需要说明的地方流程在此也加以解释。根据这些结果,本文讨论了使目前的模型与深基岩地下水流模型相结合的方法。 | Kent Werner Emma Bosson Sten Berglund 林宝法(译) 胡恩和(校) | 2006 | AMBIO-人类环境杂志2006，35，8： | 3 |
| 5 | Screening of unknown atrial fibrillation through handheld device in the elderly显示文摘Objective To estimate the prevalence of unknown atrial fibrillation(AF)in the elderly population of the Veneto Region,Italy.Methods 1820 patients aged≥65 years with no history of AF and not anticoagulated were enrolled in primary-care settings.They underwent an opportunistic electrocardiogram screening with a handheld device(My Diagnostick)designed to specifically detect AF.The electrocardiogram recordings were reviewed by the researchers,who confirmed the presence of AF.Results The device detected an arrhythmia in 143 patients,which was confirmed as AF in 101/143(70.6%),with an overall prevalence of AF of 5.5%(101/1820).Prevalence of unknown AF resulted in 3.6%in patients aged 65–74 years,and 7.5%in patients age 75 or older,and increased according to CHA2 DS2-VASc score:3.5%in patients with a score of 1 or 2,5.6%in patients with a score of 3,7.0%in patients with a score of 4,and 7.2%in patients with a score≥5.The detection rate was significantly higher in patients with mild symptoms compared to asymptomatic counterparts(24.1%vs.4.0%,P<0.0001).At multivariate analysis,congestive heart failure and age≥75 years-old were independent predictors for screen-detected AF.Conclusions An opportunistic screening with handheld device revealed an unexpectedly high prevalence of unknown AF in elderly patients with mild symptoms.Prevalence increased with age and CHA2DS2-VASc score. | Francesco Rivezzi Riccardo Vio Claudio Bilato Leopoldo Pagliani Giampaolo Pasquetto Salvatore Saccà Roberto Verlato Federico Migliore Sabino Iliceto Vito Bossone Emanuele Bertaglia | 2020 | Journal of Geriatric Cardiology2020，17，8： | 3 |
| 6 | Cardiac damage in athlete's heart: When the “supernormal” heart fails!显示文摘Intense exercise may cause heart remodeling to compensate increases in blood pressure or volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle, but all heart chambers. Physiological cardiac modeling in athletes is associated with normal or enhanced cardiac function, but recent studies have documented decrements in left ventricular function during intense exercise and the release of cardiac markers of necrosis in athlete's blood of uncertain significance. Furthermore, cardiac remodeling may predispose athletes to heart disease and result in electrical remodeling, responsible for arrhythmias. Athlete's heart is a physiological condition and does not require a specific treatment. In some conditions, it is important to differentiate the physiological adaptations from pathological conditions, such as hypertrophic cardiomyopathy, arrhythmogenic dysplasia of the right ventricle, and non-compaction myocardium, for the greater risk of sudden cardiac death of these conditions. Moreover, some drugs and performance-enhancing drugs can cause structural alterations and arrhythmias, therefore, their use should be excluded. | Andreina Carbone Antonello D’Andrea Lucia Riegler Raffaella Scarafile Enrica Pezzullo Francesca Martone Raffaella America Biagio Liccardo Maurizio Galderisi Eduardo Bossone Raffaele Calabrò | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 7 | Plasma D-dimmer testing improves the management of thrombus embolic disease in hospitalized patients显示文摘 | Barro C Bosson JL Pernod G | 1999 | Thromb Res1999，95，： | 2 |
| 8 | Early and late complications associated with transcatheter occlusion of secundum atrial septal defect显示文摘 | Massimo Chessa Mario Carminati Gianfranco Butera Roberta Margherita Bini Manuela Drago Luca Rosti Alessandro Giamberti Giuseppe Pomè Eduardo Bossone Alessandro Frigiola | 2002 | Journal of the American College of Cardiology2002，，6： | 2 |
| 9 | Fetal intracranial tumors: a review of 27 cases显示文摘 | M. Cassart N. Bosson C. Garel D. Eurin F. Avni | 2008 | European Radiology2008，，10： | 1 |
| 10 | Current Practices in Sedation and Analgesia for Mechanically Ventilated Critically Ill Patients: A Prospective Multicenter Patient-based Study显示文摘 | Jean-Francois Payen Gérald Chanques Jean Mantz Christiane Hercule Igor Auriant Jean-Luc Leguillou Michèle Binhas Céline Genty Carole Rolland Jean-Luc Bosson | 2007 | Anesthesiology2007，，4： | 1 |
| 11 | Patient referral is influenced by dialysis center structure in the diamant alpin dialysis cohort study显示文摘 | Wauters J P Bosson J L Forneris G | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 12 | A non-invasive technique for analyzing fecal cortisol metabolites in snowshoe hares(Lepus americanus)显示文摘 | Sheriff M J Bosson C O Krebs C J Boonstra R | 2009 | Journal of Comparative Physoiology2009，179，： | 1 |
| 13 | Assessing pain in critically ill sedated patients by using a behavioral pain scale 显示文摘 | Payen JF Bru O Bosson JL | 2001 | Crit Care Med2001，29，12： | 1 |
| 14 | Stroke and out- comes in patients with acute type A aortic dissection 显示文摘 | Bossone E Corteville DC Harris KM | 2013 | Circula-tion2013，128，111： | 1 |
| 15 | Progressive alterations in circular smooth muscle contractility in TNBSinduced colitis in rats显示文摘 | Hosseini JM Goldhill JM Bossone C | 1999 | Neurogastroenterol Motil1999，11，5： | 1 |
| 16 | Staking the perfect measure of implicit self- esteem : Tile blind men and the elephant revisited 显示文摘 | Bosson j K Swarm W B | 2000 | Journal of Personality and social psychology2000，79，4： | 1 |
| 17 | Partial 17,20-desmolase and 17α-hydroxylase deficiecies in a 16 year old boy显示文摘 | Bosson D Wolter R Toppet M | 1988 | J Endocrinol Invest1988，11，： | 1 |
| 18 | Pulmonary arterial hypertension:The key role of echocardiography显示文摘 | Bossone E Bodini BD Mazza A | 2005 | Chest2005，127，： | 1 |
| 19 | The fac- tor V (FV) gene ASP79HIS polymorphism modulates FV plasma levels and affects the activated protein C resistance phenotype in presence of the FV Leiden mutation显示文摘 | Bossone A Cappucci F D'Andrea G | 2003 | Haematologica2003，88，3： | 1 |
| 20 | Acute type A aor- tic dissection in the elderly : clinical characteristics, management, and outcomes in the current era显示文摘 | Mehta RH O'Gara PT Bossone E | 2002 | J Am Coil Cardiol2002，40，： | 1 |
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