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| 1 | Management of small hepatocellular carcinoma in cirrhosis:Focus on portal hypertension显示文摘The incidence of hepatocellular carcinoma(HCC) is rising worldwide being currently the fifth most common cancer and third cause of cancer-related mortality.Early detection of HCC through surveillance programs have enabled the identification of small nodules with higher frequency,and nowadays account for 10%-15% of patients diagnosed in the West and almost 30% in Japan.Patients with small HCC can be candidates for potential curative treatments:liver transplantation,surgical resection and percutaneous ablation,depending on the presence of portal hypertension and co-morbidities.This review will analyze recent advancements in the clinical management of these individuals,focusing on issues related to the role of portal hypertension,the debate between resection and ablative therapies and the future impact of molecular technologies. | Virginia Hernandez-Gea Fanny Turon Annalisa Berzigotti Augusto Villanueva | 2013 | World Journal of Gastroenterology2013，19，8： | 20 |
| 2 | Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus显示文摘AIM:To investigate whether systemic lupus erythematosus (SLE) is associated with benign focal liver lesions and vascular liver diseases, since these have been occasionally reported in SLE patients. METHODS:Thirty-five consecutive adult patients with SLE and 35 age-and sex-matched healthy controls were evaluated. Hepatic and portal vein patency and presence of focal liver lesions were studied by colour-Doppler ultrasound, computerized tomography and magnetic resonance were used to refine the diagnosis, clinical data of SLE patients were reviewed. RESULTS:Benign hepatic lesions were common in SLE patients (54% vs 14% controls, P < 0.0001), withhemangioma being the most commonly observed lesion in the two groups. SLE was associated with the presence of single hemangioma [odds ratios (OR) 5.05; 95% confidence interval (CI) 1.91-13.38] and multiple hemangiomas (OR 4.13; 95% CI 1.03-16.55). Multiple hemangiomas were associated with a longer duration of SLE (9.9 ± 6.5 vs 5.5 ± 6.4 years; P = 0.04). Imaging prior to SLE onset was available in 9 patients with SLE and hemangioma, showing absence of lesions in 7/9. The clinical data of our patients suggest that SLE pos- sibly plays a role in the development of hemangioma. In addition, a Budd-Chiari syndrome associated with nodular regenerative hyperplasia (NRH), and a NRH associated with hepatic hemangioma were observed, both in patients hospitalized for abdominal symptoms, suggesting that vascular liver diseases should be specifically investigated in this population. CONCLUSION:SLE is associated with 5-fold increased odds of liver hemangiomas, suggesting that these might be considered among the hepatic manifestations of SLE. | Annalisa Berzigotti Marilena Frigato Elena Manfredini Lucia Pierpaoli Rita Mulè Carolina Tiani Paola Zappoli Donatella Magalotti Nazzarena Malavolta Marco Zoli | 2011 | World Journal of Gastroenterology2011，17，40： | 5 |
| 3 | The management of portal hypertension: Rational basis, available treatments and future options显示文摘 | Jaime Bosch Annalisa Berzigotti Juan Carlos Garcia-Pagan Juan G. Abraldes | 2008 | Journal of Hepatology2008，，： | 3 |
| 4 | Portal Hypertension and Gastrointestinal Bleeding显示文摘 | Jaime Bosch Juan Abraldes Annalisa Berzigotti Juan Garcia-Pagan | 2008 | Semin Liver Dis2008，，01： | 3 |
| 5 | Real-time shear-wave elastography: applicability, reliability and accuracy for clinically significant portal hypertension显示文摘 | Bogdan Procopet Annalisa Berzigotti Juan G. Abraldes Fanny Turon Virginia Hernandez-Gea Juan Carlos García-Pagán Jaime Bosch | 2014 | Journal of Hepatology2014，，： | 2 |
| 6 | 肝硬化和门脉高压的诊断:影像学、非侵入性纤维化标志物和肝脏活检显示文摘肝硬化的概念一直在不断演进,现在已经明确的是,代偿期与失代偿期肝硬化预后是完全不同的。进展期慢性肝病(ACLD)这一称谓能更好地反应肝脏组织学变化的进程,比如,即使肝硬化形成了,肝脏组织学仍会继续进展;而在去除病因后,肝脏也可能会在组织学上逆向转好。对于代偿期ACLD,门脉高压标志着疾病进展到了一个并发症高危期,需要准确评估和治疗。在一些复杂的临床情况下,用以诊断肝硬化(肝脏活检)和门脉高压(肝静脉压力梯度检测)等侵入性检查仍然是至关重要的,但由于各种非侵入性检查方法在常规病例中的广泛应用,侵入性检查的临床需求已大大降低。本文对纤维化标志物、弹性成像和影像学等非侵入性检查方法的应用情况、主要优缺点进行了综述。 | Bogdan Procopet Annalisa Berzigotti | 2017 | Gastroenterology Report2017，5，2： | 2 |
| 7 | Ultrasonographic evaluation of liver surface and transient elastography in clinically doubtful cirrhosis显示文摘 | Annalisa Berzigotti Juan G. Abraldes Puneeta Tandon Eva Erice Rosa Gilabert Juan Carlos García-Pagan Jaime Bosch | 2010 | Journal of Hepatology2010，，6： | 2 |
| 8 | Pharmacologic management of portal hypertension显示文摘 | Berzigotti A Bosch J | 2014 | Clin Liver Dis2014，18，2： | 1 |
| 9 | Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats 显示文摘 | Coch L Mejias M Berzigotti A | 2014 | Hepatology2014，60，2： | 1 |
| 10 | Ultrasound in portal hypertension--part 2--and EFSUMB recommendations for the performance and reporting of ultrasound examinations in portal hypertension显示文摘 | Berzigotti A Piscaglia F | | 0，，01： | 1 |
| 11 | Noninvasive prediction of clinically significant portal hypertension and esophageal varices in patients with compensated liver cirrhosis显示文摘 | Berzigotti A Gilabert R Abraldes JG | 2008 | Am J Gastroenterol2008，103，5： | 1 |
| 12 | Portal hypertension and gastrointestinal bleeding显示文摘 | Bosch J Abraldes J G Berzigotti A | | 0，，： | 1 |
| 13 | Octreotide in the outpatient therapy of cirrhosis ehylous ascites: a case report显示文摘 | Berzigotti A Magalotti D Cocci C | 2006 | Dig liver Dis2006，38，： | 1 |
| 14 | Liver stiffness increases after a meal in patients with cirrhosis but its change does not correlate with the changes in HVPG (abstract)显示文摘 | Berzigotti A de Gottardi A Delgado MG | 2010 | Hepatology2010，52，： | 1 |
| 15 | Ultrasound in portal hypertension-part 1显示文摘 | Berzigotti A Piscaglia F | 2011 | Ultraschall Med2011，32，6： | 1 |
| 16 | Portal hypertension and the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis:A systematic review and meta-analysis显示文摘 | Berzigotti A Reig M Abraldes JG | 2015 | Hepatology2015，61，2： | 1 |
| 17 | Update on ultrasound imaging of liver fibrosis显示文摘 | Berzigotti A Castera L | 2013 | Journal of hepatology2013，59，1： | 1 |
| 18 | The management of portal hypertension:rational basis,available treatments and future options显示文摘 | Bosch J Berzigotti A Garcia-Pagan JC | | 0，，1： | 1 |
| 19 | Non-invasive diagnos-tic and prognostic evaluation of liver cirrhosis and portal hyperten-sion 显示文摘 | Berzigotti A Ashkenazi E Reverter E | 2011 | Dis markers2011，31，3： | 1 |
| 20 | Portal hypertension and gastrointestinal bleeding显示文摘 | Bosch J Abraldes JG Berzigotti A | 2008 | Semin Liver Dis2008，28，1： | 1 |
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