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| 1 | Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C显示文摘AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target. | ángel Hernández-Bartolomé Rosario López-Rodríguez María Jesús Borque Leticia González-Moreno Yolanda Real-Martínez Luisa García-Buey Ricardo Moreno-Otero Paloma Sanz-Cameno | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 2 | The role of automated measurement of red cell subpopulations on the Sysmex XE 5000 analyzer in the differential diagnosis of microcytic anemia显示文摘 | Urrechaga E Borque L | 2011 | Int J Lab Hematol2011，33，1： | 1 |
| 3 | Biomarkers of hypochromia the contemporary assessment of iron status and erythropoiesis显示文摘 | Urrechaga E Borque L Escanero JF | 2013 | Bio Med Res Int2013，2013，60： | 1 |
| 4 | Comparison of BN Pand NT- proBN Passays in the approach to the emergency diagnosis of acute dispend显示文摘 | Sanz M P Borqus L Rus A | 2006 | J Clin Lab Anal2006，20，6： | 1 |
| 5 | Erythrocyte and Reticulocyte Indices on the LH 750 as Potential Markers of Functional Iron Deficiency显示文摘 | Urrechaga E Borque L Escanero JF | 2010 | Anemia2010，2010，62： | 1 |
| 6 | Analysis of reticalocyte parameters on the sysmex XE500 and LH750 analyzers in the diagnosis of inefficent erythropolesis显示文摘 | Urrechaga E Borque L Escanero JF | 2011 | Int Lab Hematol2011，33，1： | 1 |
| 7 | Erythrocyte and reituculocyte indices on the LH750 as potential markers of functional iron deficiency显示文摘 | Urrechaga E Borque L Escanero JF | 2010 | Anemia2010，2010，62： | 1 |
| 8 | Biomarkers of hypochromia:the contemporary assessment of iron status and erythropoiesis显示文摘 | Urrechaga E Borque L Escanero JF | 2013 | Biomed Res Int2013，2013，60： | 1 |
| 9 | Preliminary evidence of sustained expression of angiopoietin‐2 during monocyte differentiation in chronic hepatitis C显示文摘 | Yolanda Rodríguez‐Mu?oz Samuel Martín‐Vílchez Rosario López‐Rodríguez ángel Hernández‐Bartolomé Luisa García‐Buey María J. Borque Ricardo Moreno‐Otero Paloma Sanz‐Cameno | 2013 | Liver Int2013，，6： | 1 |
| 10 | The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening 显示文摘 | Urrechaga E Borque L Escanero JF | 2011 | Am J Clin Pathol2011，135，3： | 1 |
| 11 | Low hemoglobin density potential marker of iron availability显示文摘 | Urrechaga E Unceta M Borque L | 2012 | Int J Lab Hematol2012，34，： | 1 |
| 12 | Erythrocyte and reticulocyte indices on the LH 750 as potential markers of functional iron deficiency显示文摘 | Urrechaga E Borque L Escanero J F | 2010 | Anemia2010，2010，62： | 1 |
| 13 | Erythrocyte and reticulocyte parameters in iron deficiency and thalassemia显示文摘 | Urrechaga E Borque L Escanero JF | 2011 | J Clin Lab Anal2011，25，3： | 1 |
| 14 | Erythrocyte and reticulocyte pa- rameters in iron deficiency and thalassemia 显示文摘 | Urrechaga E Borque L Escanero J F | 2011 | J Clin Lab Anal2011，25，3： | 1 |
| 15 | Potential utility of the new Sysmex XE 5000 red blood cell extended parameters in the study of disorders of iron metabolism 显示文摘 | Urrechaga E Borque L Escanero JF | 2009 | Clin Chem Lab Med2009，47，11： | 1 |
| 16 | Catalytic activities of Co(Ni)Mo/TiO2-Al2O3 catalysts in gasoil and thiophene HDS and pyridineHDN:effect of the TiO2-Al2O3 composition显示文摘 | Borque M P López-Agudo A Olguín E | 1999 | Applied Catalysis A:General1999，180，12： | 1 |
| 17 | The role of automated meas- urement of RBC subpopulations in differential diagnosis of microcytic anemia and 13-thalassemia screening 显示文摘 | Urrechaga E Borque L Escanero JF | 2011 | Am J Clin Pathol2011，135，3： | 1 |
| 18 | Erythrocyte and re- ticuloeyte indices in the assessment of erythropoiesis ac- tivity and iron availability显示文摘 | Urrechaga E Borque L Escanero JF | 2013 | Int J Lab Hematol2013，35，2： | 1 |
| 19 | Erythrocyte and Reticulo- cyte Indices on the LH 750 as Potential Markers of Functional Iron Deficiency显示文摘 | Urrechaga E Borque L Escanero JF | 2010 | Anemia2010，2010，62： | 1 |
| 20 | Erythrocyte and reticulocyte indeces on the LH750 as potential markers of functional iron deficiency显示文摘 | Urrechaga E Borque L Escanero JF | | 0，，： | 1 |
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