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| 1 | Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C显示文摘AIM To evaluate the efficacy of peripheral blood concentrations of angiopoietins(Ang) as cirrhosis biomarkers of chronic hepatitis C(CHC).METHODS Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays(ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system.Groups were compared by non-parametric MannWhitney U test. Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics(AUC-ROC).RESULTS Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic(P < 0.0001), Ang2 was significantly increased as CHC progressed to the end stage of liver disease(P < 0.0001). Consequently, Ang2/Ang1 ratio was notably amplified and significantly correlated with fibrosis(P < 0.0001). Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values(above 0.7, both), but the Ang2/Ang1 ratio was much better(AUC-ROC = 0.810) and displayed outstanding values of sensitivity(71%), specificity(84%) and accuracy(82.1%) at the optimal cut-off(10.33). Furthermore, Ang2/Ang1 ratio improved the performance of many other previously described biomarkers or scores of liver cirrhosis in CHC.CONCLUSION Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target. | ángel Hernández-Bartolomé Rosario López-Rodríguez María Jesús Borque Leticia González-Moreno Yolanda Real-Martínez Luisa García-Buey Ricardo Moreno-Otero Paloma Sanz-Cameno | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 2 | Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin显示文摘AIM: To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy. METHODS: One hundred and fifty three patients with a SVR after treatment with PEG-IFN plus ribavirin were included in a 5-year follow-up study in a single Spanish center, based on standard clinical practice. Clinical anamnesis, biochemical analysis, hepatitis C virus RNA and alpha-fetoprotein measurement, ultrasonography and transient elastography were performed annually. RESULTS: The mean follow-up period of the 153 patients was 76 ± 13 mo after they obtained a SVR. Five patients (3.26%) presented with cirrhosis before treatment and 116 (75.8%) had genotype 1. No patient showed evidence of hepatic decompensation. One patient (0.65%) developed a hepatocellular carcinoma at month 30 after achieving SVR. There were no virological relapses during this follow-up period. Persistently elevated alanine aminotransferase was found in only one patient (0.65%). At the end of the 5-year follow-up, the mean value of transient elastography was 7 ± 4.3 kPa (F1). There were no deaths and no other tumors. CONCLUSION: The long-term outcome of 153 CHC patients with SVR to PEG-IFN plus ribavirin was good. No evidence of a virological relapse was seen. One patient (0.65%) developed a hepatocellular carcinoma. | María Trapero-Marugán Jorge Mendoza María Chaparro Leticia González-Moreno José Andrés Moreno-Monteagudo María Jesús Borque Ricardo Moreno-Otero | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 3 | Study of the escretion of substance P,neurotensin and somatostatin in patients with chololithiasis显示文摘 | LOPEZ DO SARMIENTO JM BORQUE M | 1997 | Rev Esp Enferm Dig1997，89，6： | 1 |
| 4 | The role of automated measurement of red cell subpopulations on the Sysmex XE 5000 analyzer in the differential diagnosis of microcytic anemia显示文摘 | Urrechaga E Borque L | 2011 | Int J Lab Hematol2011，33，1： | 1 |
| 5 | Biomarkers of hypochromia the contemporary assessment of iron status and erythropoiesis显示文摘 | Urrechaga E Borque L Escanero JF | 2013 | Bio Med Res Int2013，2013，60： | 1 |
| 6 | Use of sedation in gastrointestinal endoscopy: a nationwide survey in Spain显示文摘 | Juan-Salvador Baudet Pilar Borque Elisa Borja Onofre Alarcón-Fernández Antonio Sánchez-del-Río Rafael Campo Juan Avilés | 2009 | European Journal of Gastroenterology & Hepatology2009，，8： | 1 |
| 7 | Comparison of BN Pand NT- proBN Passays in the approach to the emergency diagnosis of acute dispend显示文摘 | Sanz M P Borqus L Rus A | 2006 | J Clin Lab Anal2006，20，6： | 1 |
| 8 | Use of sedation in gastrointestinal endoscopy:a nationwide survey in Spain显示文摘 | Baudet JS Borque P Borja E | 2009 | Eur J Gastroenterol Heptol2009，21，： | 1 |
| 9 | Erythrocyte and Reticulocyte Indices on the LH 750 as Potential Markers of Functional Iron Deficiency显示文摘 | Urrechaga E Borque L Escanero JF | 2010 | Anemia2010，2010，62： | 1 |
| 10 | Analysis of reticalocyte parameters on the sysmex XE500 and LH750 analyzers in the diagnosis of inefficent erythropolesis显示文摘 | Urrechaga E Borque L Escanero JF | 2011 | Int Lab Hematol2011，33，1： | 1 |
| 11 | Use of sedation in gastrointestinal endoscopy: a nationwide survey in Spain显示文摘 | Juan-Salvador Baudet Pilar Borque Elisa Borja Onofre Alarcón-Fernández Antonio Sánchez-del-Río Rafael Campo Juan Avilés | 2009 | European Journal of Gastroenterology & Hepatology2009，，8： | 1 |
| 12 | Erythrocyte and reituculocyte indices on the LH750 as potential markers of functional iron deficiency显示文摘 | Urrechaga E Borque L Escanero JF | 2010 | Anemia2010，2010，62： | 1 |
| 13 | Biomarkers of hypochromia:the contemporary assessment of iron status and erythropoiesis显示文摘 | Urrechaga E Borque L Escanero JF | 2013 | Biomed Res Int2013，2013，60： | 1 |
| 14 | Preliminary evidence of sustained expression of angiopoietin‐2 during monocyte differentiation in chronic hepatitis C显示文摘 | Yolanda Rodríguez‐Mu?oz Samuel Martín‐Vílchez Rosario López‐Rodríguez ángel Hernández‐Bartolomé Luisa García‐Buey María J. Borque Ricardo Moreno‐Otero Paloma Sanz‐Cameno | 2013 | Liver Int2013，，6： | 1 |
| 15 | The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening 显示文摘 | Urrechaga E Borque L Escanero JF | 2011 | Am J Clin Pathol2011，135，3： | 1 |
| 16 | Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty显示文摘 | ALVAREZ_BARTOLOME M BORQUE M MARTINEZ-SARMIENTO J | | 0，，： | 1 |
| 17 | Catalytic activities of Co(Ni)Mo/TiO2 -Al2O3 catalysts in gasoil and thiophene HDS and pyridine HDN: effect of the TiO2 - Al2O3 comosifion显示文摘 | Borque M P Lopez - agudo A Olguin E etal | 1999 | Applied Catalysis A : General1999，180，12： | 1 |
| 18 | Effect of washing oil on in vitro development of mouse embryos显示文摘 | Borque C Pintado B García P | 1996 | Theriogenology1996，45，1： | 1 |
| 19 | Low hemoglobin density potential marker of iron availability显示文摘 | Urrechaga E Unceta M Borque L | 2012 | Int J Lab Hematol2012，34，： | 1 |
| 20 | Erythrocyte and reticulocyte indices on the LH 750 as potential markers of functional iron deficiency显示文摘 | Urrechaga E Borque L Escanero J F | 2010 | Anemia2010，2010，62： | 1 |
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