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| 1 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 2 | 显示文摘 | Millis A J Boris I Shraiman Mueller R | 1996 | Phys Rev Lett1996，77，： | 1 |
| 3 | SHASTA, a fluid transport algorithm that works显示文摘 | BORIS J P BOOK D L Flux-corrected transport: I | 1973 | Journal of Computational Physics1973，11，1： | 1 |
| 4 | Biosynthesis of Vitamin B2 显示文摘 | Boris I Wolfgang E Nicholas S | 2005 | J Biol Chem2005，31，28： | 1 |
| 5 | Is Mitral Valve Repair Safe Procedure in Elderly Patients?显示文摘 | Igor Medved Darko Ani? Marin O?tri? Boris Zrni? Aldo Ivan?i? Vjekoslav Tomuli? | 2010 | Collegium Antropologicum2010，，2： | 1 |
| 6 | The future of the fullerenes显示文摘 | RICHARD E A BORIS I Y | 1998 | Solid State Comunication1998，107，11： | 1 |
| 7 | Development of an injectable formulation of albendazole and in vivo evaluation of its eflficacy against Echinococcus multilocularis metacestode显示文摘 | Rodrigues JM Jr Bories C Emery I | | 0，，12： | 1 |
| 8 | Development of an injectable formulation albendazole and in vivo evaluation of efficacy against echioncoccosis multilocularis metacestode显示文摘 | Bories C Emery I | 1995 | Int J Parasitol1995，25，12： | 1 |
| 9 | MT1 MMP initiates activation of pro-MMP-2 and integrin αvβ3 promotes maturation of MMP 2 in breast carcinoma cells显示文摘 | Elena I D Boris R Edward M et aZ | 2001 | Exp Cell Res2001，263，2： | 1 |
| 10 | γ-APTES modified silica gels: the structure of the surface layer 显示文摘 | Alexander A G Alexander I Z Boris V Z | 1996 | Journal of Colloid and Interface Science1996，179，： | 1 |
| 11 | Algorithms for Computing Parsimonious Evolutionary Scenarios for Genome Evolution, the Last Universal Common Ancestor and Dominance of Horizontal Gene Transfer in the Evolution of Prokaryotes显示文摘 | Boris G Mirkin Trevor I Fenner Michael Y Galperin and Eugene V Koonin | 2003 | BMC Evolutionary Biology2003，3，1： | 1 |
| 12 | Glycerol reforming in supercritical water; a short review显示文摘 | Elena Marko?i? Boris Kramberger Joost G. van Bennekom Hero Jan Heeres John Vos ?eljko Knez | 2013 | Renewable and Sustainable Energy Reviews2013，，： | 1 |
| 13 | Value of thediffusion-weighted MRI in the differential diagnostics ofmalignant and benign kidney neoplasms-our clinicalexperience显示文摘 | Mytsyk Y Borys Y Komnatska I | 2014 | Pol J Radiol2014，79，： | 1 |
| 14 | XPS and TEM studies on the role of the support and alkali promoter in Ru/MgO and Ru-Cs+/MgO catalysts for ammonia synthesis显示文摘 | Larichev Yurii V Moroz Boris L Zaikovskii Vladimir I | 2007 | J Phys Chem C2007，111，： | 1 |
| 15 | Cerebral venous thrombosis:a review of 38 cases显示文摘 | Chiras I Bories J | 1995 | Stroke1995，16，2： | 1 |
| 16 | Determinants of alliance portfolio complexity and its effect on innovative performance of companier显示文摘 | GEERT D BORIS I | 2011 | Product Development & Management As-sociation2011，，28： | 1 |
| 17 | DNA content in Eurasian sturgeon species determined by flow cytometry显示文摘 | Birstein V J Andrei I P Boris F G | 1993 | Cytometry1993，14，： | 1 |
| 18 | Overview on the synthesis of activated micro-and nanostructurized rieke metals:History and present state显示文摘 | Luis A Garza-Rodríguez Boris I Kharisov Oxana V Kharissova | 2009 | Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry2009，39，： | 1 |
| 19 | “I know you self-handicapped last exam”:Gender differences in reactions to self-handicapping显示文摘 | Hirt E R McCrea S M Boris H I | 2003 | Journal of Personality and Social Psychology2003，84，： | 1 |
| 20 | New diterpenoids from the far-eastern gorgonian coral Plumarella sp.显示文摘 | Valentin A Stonik Irina I Kapustina Anatoly I Kalinovsky Pavel S Dmitrenok Boris B Grebnev | 2002 | Tetrahedron Letters2002，，2： | 1 |
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