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| 1 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 2 | Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists显示文摘Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children. | Priscila Menezes Ferri Alexandre Rodrigues Ferreira Débora Marques Miranda Ana Cristina Sim■es e Silva | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Empathic abilities in people with schizophrenia显示文摘 | Bora E Gokcen S Veznedaroglu B | 2008 | Psychiatry Res2008，160，1： | 1 |
| 4 | Cognitive endophenotypes of bipoiar disorder: a meta - analysis of neuropsychological deficit in euthymic patients and their frist - degree relatives显示文摘 | Bora E Yucel M Pantelis C | 2009 | J Affect Disord2009，113，12： | 1 |
| 5 | Cognitive endophenotypes of bipolardisorder : a meta - analysis of neuropsychological deficits in euthymicpatients and their first - degree relatives 显示文摘 | Bora E Yucel M Pantelis C | 2009 | J Affect Disord2009，113，12： | 1 |
| 6 | Analysis of oral mucosal lesions in patients referred to oral medicine specialists 显示文摘 | Brailo V Boras VV Pintar E | 2013 | LijecVjesn2013，135，78： | 1 |
| 7 | A review: Fibre metal laminates, background, bonding types and ap- plied testmethods显示文摘 | Sinmazcelik T Avcu E Bora M O | 2011 | Materials & Design2011，32，7： | 1 |
| 8 | Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway显示文摘 | Boras E Slevin M Alexander MY | 2014 | Cytokine2014，69，2： | 1 |
| 9 | White matter microstruc- turein opiate addiction显示文摘 | Bora E Yucel M Fornito A | 2012 | Addict Biol2012，17，1： | 1 |
| 10 | Cognitive endopheno- types of bipolar disorder: a meta-analysis of neuropsychologi- cal deficits in euthymie patients and their first-degree relatives 显示文摘 | BORA E YUCEL M PANTELIS C | 2009 | Journal of AHective Disorders2009，113，12： | 1 |
| 11 | Executive and verbal working Memory dysfunction in first-degree relatives of patients with bipolar disorder显示文摘 | Bora E Vahip E Akdeniz F | 2008 | Psychiatry Research2008，161，3： | 1 |
| 12 | Voxelwise meta - analysis of gray matter abnormalities in bipolar disorder显示文摘 | Bora E Fomito A Yucel M | 2010 | Biol Psychiatry2010，67，11： | 1 |
| 13 | Cognitive functioning in schizo - phrenia, schizoaffective disorder and affective psychoses: meta- analytic study显示文摘 | Bora E Yucel M Pantelis C | 2009 | Br J Psychiatry2009，195，6： | 1 |
| 14 | Cognitive endopheno types of bipolar disorder: a meta-analysis of neuropsycholog ical deficits in euthymic patients and their first degree rela rives 显示文摘 | Bora E Yucel M Pantclis C | 2009 | J AffectDisord2009，113，12： | 1 |
| 15 | The effect of galantamine added to clozapine on cognition of five patients with schizophrenia显示文摘 | Bora E Veznedaroglu B Kayahan B | 2005 | Clin Neuropharmacol2005，28，3： | 1 |
| 16 | Sustained attention def- icits in manic and euthymic patients with bipolar disorder 显示文摘 | Bora E Vahip S Akdeniz F | 2006 | Prog Neuropsychopharmacol Biol Psychiatry2006，30，6： | 1 |
| 17 | Isserum human chorionic gonadotrophin follow-up necessary after suspected spillage of trophoblast at the time of laparoscopic surgery for ectopic pregnancy显示文摘 | Bora SA Kirk E Daemen A | | 0，，04： | 1 |
| 18 | Empathic abilities in people with schizophrenia显示文摘 | Bora E Gokcen S Veznedaroglu B | 2008 | Psychiatry Res2008，160，1： | 1 |
| 19 | Cognitive impairment in affective psychoses: a meta - analysis 显示文摘 | Bora E Yucel M Pantelis C | 2010 | Schizophr Bull2010，36，1： | 1 |
| 20 | Different microbial biofilm formation on polymethylmethacrylate(PMMA)bone cement loaded with gentamicin and vancomycin显示文摘 | Bertazzoni Minelli E Della Bora T Benini A | | 0，，06： | 1 |
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