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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Concentration and localization of zinc during seed development and germination in wheat 显示文摘 | Ozturk L Yazici M A Yucel C | 2006 | Physiologia Plantarum2006，128，： | 1 |
| 3 | Effect of light intensity, wavelength and illumination protocol on hydrogen production in photobioreactors 显示文摘 | Uyar B Eroglu I Yucel M | 2007 | International Journal of Hydrogen Energy2007，52，18： | 1 |
| 4 | Electrophysiological assessment of the autonomic nervous system in male patients with acromegaly 显示文摘 | OZ O TASLIPINAR A YUCEL M | 2011 | Eur neurot2011，66，1： | 1 |
| 5 | Hippocampal metabolic abnormalities at first onsetand with recurrent episodes of a major depressivedisorder : A proton magnetic resonance spectroscopystudy 显示文摘 | MILNE A MACQUEEN G M YUCEL K | 2009 | Neuroimage2009，47，： | 1 |
| 6 | Effect of dexmedeto-midine on bleeding during tympanoplastyor septorhinoplasty显示文摘 | Durmus M But A K Dogan Z Yucel A | | 0，，05： | 1 |
| 7 | Biohydrogen production by Rhodobacter capsulatus Hup- mutant in pilot solar tubular photobioreactor 显示文摘 | BORAN E OZGUR E YUCEL M | 2012 | Interna tional Journal of Hydrogen Energy2012，37，16： | 1 |
| 8 | Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，3： | 1 |
| 9 | Differential diagnosis of carpal tunnel syndrome显示文摘 | Akgun H Yucel M Oz O | 2014 | Turk Neurosurg2014，24，1： | 1 |
| 10 | A pilot study to evaluate the adhesion of oral microorganisms to temporary soft lining materials显示文摘 | Bal BT Yavuzyilmaz H Yucel M | 2008 | J Oral Sci2008，50，1： | 1 |
| 11 | Photobiological hydrogen production from olive mill wastewater as sole substrate sources显示文摘 | Eroglu E Gunduz I Yucel M | 2004 | International Journal of Hydrogen Energy2004，29，2： | 1 |
| 12 | An evaluation of in-ternal carotid artery and cerebral blood flow volume usingcolor duplex sonography in patients with vertebral arteryhypoplasia显示文摘 | A car M Degirmenci B Yucel A | 2005 | Eur J Radiol2005，53，3： | 1 |
| 13 | The importance of socialcapital to the management of multinational enterprises: Re- lational networks among Asian and Western firms显示文摘 | Hitt M A Ho-Uk L Yucel E | 2002 | Asia Pacific Journal of Management2002，19，23： | 1 |
| 14 | Early cogulopathy in multiple iniury: an analysis from the German Trauma Registry on 872 patients显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，29： | 1 |
| 15 | Proanthocyanidin prevents myocardial ischemic injury in adult rats显示文摘 | GULER A SAHIN M A YUCEL O | 2011 | Med Sci Monit2011，17，11： | 1 |
| 16 | Functional and biochemical alterations of the medial frontal cortex in obsessive -compulsive disorder显示文摘 | Yucel M Harrison BJ Wood SJ | 2007 | Arch Gen Psychiatry2007，64，： | 1 |
| 17 | Oil price shocks and the US economy: where does the asymmetry originate? 显示文摘 | Balke N S Brown S P A Yucel M K | 2002 | Energy Journal2002，，23： | 1 |
| 18 | Early coagulopathy inmultiple injury:an analysis from the German Trauma Regis-try on 8724 patients显示文摘 | Maegele M Lefering R Yucel N | 2007 | Injury2007，38，3： | 1 |
| 19 | Prevalence and antibiotic resistance of Listeria species in meat products in Ankara, Turkey 显示文摘 | YUCEL N CITAK S ONDER M | 2005 | Food Microbiol2005，22，2： | 1 |
| 20 | Using a Petri-Net-Based approach for the real-time supervisory control of an experimental manufacturing system 显示文摘 | JONES A H YUCEL I | 2000 | Int J of Advanced Manufacturing Technology2000，16，7： | 1 |
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