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| 1 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 2 | TLR9-targeted biodegradable nanoparticles as immunization vectors protect a?gainst West Nile encephalitis显示文摘 | DEMENTO S L BONAFE N CUI W G | 2010 | J Immunol2010，185，5： | 1 |
| 3 | Polymorphic variants of insulin-like growth factor Ⅰ receptor and phosphoin- ositide 3-kinase genes affect IGF-1 plasma levels and human longevity: cues for an evolutionarily conserved mechanismof life span controle显示文摘 | Bonafe M Barbieri M Marchegiani F | 2003 | The journal of clinical endocrinology and meta- bolism2003，88，7： | 1 |
| 4 | Ultrastructural and histochemical examination of alveolar bone at the pressure areas of rat molars submitted to continuousorthodontic force显示文摘 | Bonafe Oliveira L Faltin RM Arana Chavez VE | 2003 | Eur J Oral Sci2003，111，： | 1 |
| 5 | DNA polymorphisms of the KiSS1 3'Untranslated region interfere with the folding of a G-rich sequence into G-quadruplex显示文摘 | Huijbregts L Roze C Bonafe G | | 0，，02： | 1 |
| 6 | Short interfering Rna directed against the SLUG gene increases cell death induction in human melanoma cell lines exposed to cisplatin and fotemustin 显示文摘 | Vannini I Bonafe M Tesei A | 2007 | CellOncol2007，29，4： | 1 |
| 7 | Stent-assisted coiling of complex middle cer ebral artery aneurysms: initial and midterm results显示文摘 | Vendrell J F Costalat V Brunel H Riquelme C Bonafe A | 2011 | AJNR Am J Neuroradiol2011，32，： | 1 |
| 8 | Genetic polymorphism in long- lived people: Cues for the presence of an insulin/IGF - pathway dependent network affecting human longevity 显示文摘 | Bonafe M Olivieri F | 2009 | Mol Cell Endocrinol2009，299，1： | 1 |
| 9 | Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia显示文摘 | BONAFE L THONY B PENZIEN J M | 2001 | Am J Med Genet2001，69，2： | 1 |
| 10 | Extended tetrahydrobiopterin loading test in the diagnosis of cofactorresponsive phenylketonuria显示文摘 | FIEGE B BONAFE L BALLHAUSEN D | 2005 | A Pilot Study2005，86，： | 1 |
| 11 | Endovascular treatment of intracrani-al aneurysms using Matrix coils:short-and mid-term results in ruptured and unruptured aneurysms显示文摘 | Pierot L Leclrc X Bonafe A | 2008 | Neurosurgery2008，63，1： | 1 |
| 12 | Poly- mophicvariants of insulin-like growth factor I (IGF-I) receptor and phostldeklnase genes aect IGF-I plasma levels and human longevity: cues for an evolutionarilyconserved mechanism ofllfe span control显示文摘 | BONAFE M BARBIERI M MARCHFIANI F ctal | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 13 | Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls 显示文摘 | Gaspari L Pedotti P Bonafe M | 2003 | Biomarkers2003，8，6： | 1 |
| 14 | Endovascular treatment of intracranial aneurysms with matrix detachable coils: midterm anatomic follow-up from a prospective multicenter registry 显示文摘 | Pierot L Leclerc X Bonafe A | 2008 | AJNR2008，29，： | 1 |
| 15 | Evaluation of urinary acylglycines by electrospray tandem mass spectrometry in mitochondrial energy metabolism defects and organic acidurias显示文摘 | Bonafe L Troxler H Kuster T | 2000 | Mol Genet Metab2000，69，4： | 1 |
| 16 | Lack of progressive arteriopathy and stroke recurrence among children with cryptogenic stroke显示文摘 | Stephane Darteyre Stephane Chabrier Emilie Presles Alain Bonafé Agathe Roubertie Bernard Echenne Nicolas Leboucq Francois Rivier | 2012 | Neurology2012，，24： | 1 |
| 17 | Inflamm-aging: an evolutionary perspective on immunosenescence 显示文摘 | Franceschi C Bonaf'e M Valensin S | 2000 | Ann N Y Acad Sci2000，908，： | 1 |
| 18 | p66 (shc) is highly expressed in fibroblasts from centenarians显示文摘 | Pandolfi S Bonafe M Di Tella L | 2005 | Mech Ageing Dev2005，126，8： | 1 |
| 19 | Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire revascularization device with 1V tPA with IV tPA alone in acute ischemic stroke显示文摘 | Saver JL Goyal M Bonafe A | 2015 | Int J Stroke2015，10，3： | 1 |
| 20 | Endovascular treatment of intracranial aneurysms with Matrix detachable coils: midterm anatomic follow-up from a prospective multicenter registry 显示文摘 | Pierot L Leclerc X Bonafe A | 2008 | AJNR2008，29，： | 1 |
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