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| 1 | DNA倍体分析系统用于宫颈癌及上皮内瘤变的诊断及预测显示文摘 | 孙小蓉 汪键 Alfred Boecking | 2005 | 中华病理学杂志2005，34，7： | 60 |
| 2 | UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer显示文摘AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy. | Christoph Schulz Volker Heinemann Andreas Schalhorn Nikolas Moosmann Thomas Zwingers Stefan Boeck Clemens Giessen Hans-Joachim Stemmler | 2009 | World Journal of Gastroenterology2009，15，40： | 31 |
| 3 | Importance of performance status for treatment outcome in advanced pancreatic cancer显示文摘Despite progress in the treatment of advanced and metastatic pancreatic cancer (PC), the outcome of this disease remains dismal for the majority of patients. Given the moderate efficacy of treatment, prognostic factors may help to guide treatment decisions. Several trials identified baseline performance status as an important prognostic factor for survival. Unfit patients with a Karnofsky performance status (KPS) below 70% only have a marginal benefit from chemotherapy with gemcitabine (Gem) and may often benefit more from optimal supportive care. Once, however, the decision is taken to apply chemotherapy, KPS may be used to select either mono- or combination chemotherapy. Patients with a good performance status (KPS = 90%-100%) may have a significant and clinically relevant survival benefit from combination chemotherapy. By contrast, patients with a poor performance status (KPS ≤ 80%) have no advantage from intensified therapy and should rather receive single-agent treatment. | Stefan Boeck Axel Hinke Ralf Wilkowski Volker Heinemann | 2007 | World Journal of Gastroenterology2007，13，2： | 14 |
| 4 | Prognostic value of CA 19-9, CEA, CRP, LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer: results from a multicenter, pooled analysis of patients receiving palliative chemotherapy显示文摘 | Michael Haas Volker Heinemann Frank Kullmann Rüdiger P. Laubender Christina Klose Christiane J. Bruns Stefan Holdenrieder Dominik P. Modest Christoph Schulz Stefan Boeck | 2013 | Journal of Cancer Research and Clinical Oncology2013，，4： | 4 |
| 5 | Systemic treatment of advanced pancreatic cancer显示文摘 | Volker Heinemann Michael Haas Stefan Boeck | 2011 | Cancer Treatment Reviews2011，，7： | 3 |
| 6 | Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR显示文摘 | Volker Heinemann Sebastian Stintzing Thomas Kirchner Stefan Boeck Andreas Jung | 2008 | Cancer Treatment Reviews2008，，3： | 3 |
| 7 | KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer显示文摘 | Stefan Boeck Andreas Jung Rüdiger P. Laubender Jens Neumann Rosalind Egg Clara Goritschan Steffen Ormanns Michael Haas Dominik P. Modest Thomas Kirchner Volker Heinemann | 2013 | Journal of Gastroenterology2013，，4： | 2 |
| 8 | Climate warming shifts the time interval between flowering and leaf unfolding depending on the warming period显示文摘The timing of flowering(FL)and leaf unfolding(LU)determine plants’reproduction and vegetative growth.Global warming has substantially advanced FL and LU of temperate and boreal plants,but their responses to warming differ,which may influence the time interval between FL and LU(ΔLU-FL),thereby impacting plant fitness and intraspecific physiological processes.Based on twigs collected from two flowering-first tree species,Populus tomentosa and Amygdalus triloba,we conducted a manipulative experiment to investigate the effects of winter chilling,spring warming and photoperiod on theΔLU-FL.We found that photoperiod did not affect theΔLU-FL of Amygdalus triloba,but shortenedΔLU-FL by 5.1 d of Populus tomentosa.Interestingly,spring warming and winter chilling oppositely affected theΔLU-FL of both species.Specifically,low chilling accumulation extended theΔLU-FL by 3.8 and 9.4 d for Populus tomentosa and Amygdalus triloba,but spring warming shortened theΔLU-FL by 4.1 and 0.2 d℃^(-1).Our results indicate that climate warming will decrease or increase theΔLU-FL depending on the warming periods,i.e.,spring or winter.The shifted time interval between flowering and leaf unfolding may have ecological effects including affecting pollen transfer efficiency and alter the structure and functioning of terrestrial ecosystem. | Shuxin Wang Zhaofei Wu Yufeng Gong Shubiao Wang Wei Zhang Shanshan Zhang Hans J.De Boeck Yongshuo H.Fu | 2022 | Science China(Life Sciences)2022，65，11： | 2 |
| 9 | Analysis and modeling of low-frequency noise in resistive FET mixers 显示文摘 | Margraf M Boeck G | 2004 | Microwave Theory and Techniques2004，52，7： | 1 |
| 10 | Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling显示文摘 | De Boeck A Pauwels P Hensen K | | 0，，： | 1 |
| 11 | Acute effects of aerosolized Iioprost in COPD related pulmonary hypertension-A randomized controlled crossover trial显示文摘 | Boeck L Tamm M Grendelmeier P | 2012 | Plos One2012，7，52： | 1 |
| 12 | New model for gastroentero- pancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines 显示文摘 | Krieg A Mersch S Boeck I | 2014 | PLoS One2014，9，88： | 1 |
| 13 | Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer 显示文摘 | Heinemann V Boeck S Hinke A | 2008 | BMC Cancer2008，8，： | 1 |
| 14 | Deacylation of echinocandin B by Actinoplanes utahensis显示文摘 | Boeck L D Fukuda D S Abbott B J | 1989 | J Antibiot (Tokyo)1989，42，3： | 1 |
| 15 | The sequential organ failure assessment score and eopeptin for predicting survival in ventilator-associated pneumonia显示文摘 | Boeck L Eggimann P Smymios N et 81 | 2012 | J Crit Care2012，27，5： | 1 |
| 16 | Ataluren (PTCI24) induces cystic fibrosis transmembrane conductance regulator pro- tein expression and activity in children with nonsense mutation cys-tic fibrosis 显示文摘 | Sermet-Gaudelus I Boeck KD Casimir GJ | 2010 | Am J Respir Crit Care Med2010，182，10： | 1 |
| 17 | Tissue-specific Cu bioaccumulation patterns and differences in sensitivity to waterborne Cu in three freshwater fish: Rainbow trout ( Oncorhynchus myla'ss), common carp (Cypnnus carpio) and gibel carp (Carassius auratus gibelio) 显示文摘 | De Boeck G Meeu W De Coen W | 2004 | Aquatic Toxicology2004，70，3： | 1 |
| 18 | Transforming growth factor beta1 treatment leads to an epithelial mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation显示文摘 | EllenriederV Hendler SF Boeck W | 2001 | Cancer Res2001，61，42： | 1 |
| 19 | Deacylation of echinocandin B by Actinoplanes utahensis显示文摘 | BOECK L D FUKUDA D S ABBOTT B J | 1989 | J Antibiot1989，42，3： | 1 |
| 20 | Cytologic and DNA-cytometric very early diagnosis of oral cancer显示文摘 | Maraki D Becker J Boecking A | 2004 | J Oral Pathol Med2004，33，7： | 1 |
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