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| 1 | Side-chain and backbone amide bond requirements for glycopeptide stimulation of T- cells obtained in a mouse model for rheumatoid arthritis显示文摘 | HOLM L BOCKERMANN R WELLNER E | 2006 | Bioorganic & Medicinal Chemistry2006，14，17： | 1 |
| 2 | ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation显示文摘A disintegrin and metalloproteinase(ADAM)12 was previously found to be expressed in T cells in the inflamed brain.However,the function of ADAM12 in T-cell responses in general and in tissue inflammation has not been examined.Here,we studied the role of ADAM12 in T-cell responses,fate determination on activation,and its functions in T cells to mediate tissue inflammation.We identified ADAM12 as a costimulatory molecule that is expressed on naive T cells and downregulated on stimulation.ADAM12 mimics CD28 costimulatory signaling to activate and induce the proliferation of T-helper 1(Th1)cells.Monoclonal ADAM12 Fab antibodies trigger T-cell activation by amplifying TCR signaling to stimulate T-bet-mediated IFNγproduction.Lack of genomic ADAM12 and its knockdown in T cells diminished T-bet and IFNγproduction in Th1 cells,whereas other T cells,including Th17 cells,were unaffected.ADAM12 had similar functions in vivo on myelin antigen(MOG_(35-55))-induced T-cell activation.We found that genetic loss of ADAM12 profoundly alleviated Th1-mediated neuroinflammation and thus disease severity in experimental autoimmune encephalomyelitis,a model of multiple sclerosis.Transcriptomic profiling of MOG_(35-55)-specific ADAM12^(−/−)T cells revealed differentially expressed genes that are important for T-cell activation,proliferation,and costimulatory signaling and Th1 pathogenicity,consistent with their inability to cause T-cell-mediated skin inflammation in a model of adoptive delayed-type hypersensitivity.We conclude that ADAM12 is a T-cell costimulatory molecule that contributes to the pathogenesis of tissue inflammation and a potential target for the treatment of Th1-mediated diseases. | Yawei Liu Robert Bockermann Mahdieh Hadi Iman Safari Belinda Carrion Marie Kveiborg Shohreh Issazadeh-Navikas | 2021 | Cellular & Molecular Immunology2021，18，8： | 1 |
| 3 | Side-chainand backbone amide bond requirements for glycopeptide stimulation of T- cells obtained in a mouse model for rheumatoid arthritis显示文摘 | HOLM L BOCKERMANN R WELLNER E | 2006 | Bioorganic & Medicinal Chemistry2006，，14： | 1 |
| 4 | Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R | 2005 | Eur J Immunol2005，35，5： | 1 |
| 5 | Expression of nistric oxide synthase isozymes(NOSI-Ⅲ) by immunohistochemistry and DNA in situ hybridization:correlation with macrophage presence,VEGF and Ocedema Volumtric date in 220 glioblastomas显示文摘 | Feiz-erfan I Bockermann V | 2000 | Anti-Cancer Res2000，20，： | 1 |
| 6 | Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R | 2005 | Eur J Immunol2005，35，： | 1 |
| 7 | Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis显示文摘 | HOLM L BOCKERMANN R WELLNER E | 2006 | Bioorganic and Medicinal Chemistry2006，14，17： | 1 |
| 8 | Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R | 2005 | Eur J Immunol2005，35，： | 1 |
| 9 | Glycosylation of type Ⅱ collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis 显示文摘 | Backlund J Treschow A Bockermann R | 2002 | Eur J Immunol2002，32，12： | 1 |
| 10 | Humoral immune response to citrullinated collagen typeⅡdeterminants in early rheumatoid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R | 2005 | Eur J Immunol2005，35，5： | 1 |
| 11 | Structure and pathogenicity of antibodies specific for citrullinated collagen type Ⅱ in experimental arthritis显示文摘 | Uysal H Bockermann R Nandakumar KS | | 0，，： | 1 |
| 12 | Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R et ag | 2005 | Eur J Immunol2005，35，5： | 1 |
| 13 | Structure and pathogenicity of antibodies speciic for citrullinated collagen type II in experimental arthritis显示文摘 | Uysal H Bockermann R Nandakumar KS | 2009 | JEM2009，2，9： | 1 |
| 14 | Humoral immune re- sponse to citrullinated collagen type II determinants in early rheuma- toid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R | 2005 | Eur J Immunol2005，35，5： | 1 |
| 15 | Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis显示文摘 | Lotta Holm Robert Bockermann Erik Wellner | 2006 | Bioorganic & Medicinal Chemistry2006，，5： | 1 |
| 16 | Humoral im- mune response to citrullinated collagen type II determinants in early rheumatoid arthritis显示文摘 | Burkhardt H Sehnert B Bockermann R etal | 2005 | Eur J Immunol2005，35，： | 1 |
| 17 | Humoral immune response to citrullinated collagen type Ⅱ determinants in early rheumatoid arthritis显示文摘 | Sehnert B Bockermann R | 2005 | Eur J Imm unol2005，35，5： | 1 |
| 18 | Atypical and malignant meningiomas: evaluation of different radiological criteria based on CT and MR显示文摘 | Verheggen R Finkenstaedt M Bockermann V | 1996 | Acta Neurochir Suppl( Wien)1996，65，1： | 1 |
| 19 | Induction of a ]3- cell-dependent chronic arthritis with glucose-6-phosphate isomer- ase显示文摘 | Bockermann R Schubert D Kamradt T | 2005 | Arthritis Res Ther2005，7，6： | 1 |
| 20 | Adjunctive antide- pressant treatment with quetiapine in agitated depression: positive effects on symptom reduction, psychopathology and remission rates 显示文摘 | Dannlowski U Baune BT Bockermann I | 2008 | Hum Psychopharmacol2008，23，7： | 1 |
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