|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypercalciuria switches Ca^(2+) signaling in proximal tubular cells,induces oxidative damage to promote calcium nephrolithiasis显示文摘Proximal tubule(PT)transports most of the renal Ca^(2+),which was usually described as paracellular(passive).We found a regulated Ca^(2+)entry pathway in PT cells via the apical transient receptor potential canonical 3(TRPC3)channel,which initiates transcellular Ca^(2+)transport.Although TRPC3 knockout(−/−)mice were mildly hypercalciuric and displayed luminal calcium phosphate(CaP)crystals at Loop of Henle(LOH),no CaP+calcium oxalate(CaOx)mixed urine crystals were spotted,which are mostly found in calcium nephrolithiasis(CaNL).Thus,we used oral calcium gluconate(CaG;2%)to raise the PT luminal[Ca^(2+)]o further in TRPC3−/−mice for developing such mixed stones to understand the mechanistic role of PT-Ca^(2+)signaling in CaNL.Expectedly,CaG-treated mice urine samples presented with numerous mixed crystals with remains of PT cells,which were pronounced in TRPC3−/−mice,indicating PT cell damage.Notably,PT cells from CaG-treated groups switched their mode of Ca^(2+)entry from receptor-operated to store-operated pathway with a sustained rise in intracellular[Ca^(2+)]([Ca^(2+)]i),indicating the stagnation in PT Ca^(2+)transport.Moreover,those PT cells from CaG-treated groups demonstrated an upregulation of calcification,inflammation,fibrotic,oxidative stress,and apoptotic genes;effects of which were more robust in TRPC3 ablated condition.Furthermore,kidneys from CaG-treated groups exhibited fibrosis,tubular injury and calcifications with significant reactive oxygen species generation in the urine,thus,indicating in vivo CaNL.Taken together,excess PT luminal Ca^(2+)due to escalation of hypercalciuria in TRPC3 ablated mice induced surplus CaP crystal formation and caused stagnation of PT[Ca^(2+)]i,invoking PT cell injury,hence mixed stone formation. | Samuel Shin Cliff-Lawrence Ibeh Eugenia Awuah Boadi Bok-Eum Choi Sanjit K.Roy Bidhan C.Bandyopadhyay | 2022 | Genes & Diseases2022，9，2： | 2 |
| 2 | Mitigation strategies to reduce enteric methane emission from dairy cows: update review 显示文摘 | Boadi D Benchaar C Chiquette J | 2004 | Can J Anita Sci2004，，： | 1 |
| 3 | Designing of suitable construction of high-frequency induction heating coil by using finite-element method显示文摘 | Boadi A Tsuchida Y Todaka T | 2005 | IEEE Transactions on Magnetics2005，41，10： | 1 |
| 4 | Methane production from dairy and beef heifers fed forages differing in nutrient density using the sulphur hexafluoride (SF6) tracer gas technique显示文摘 | BOADI D A WITTENDERG K M | 2004 | Canadian Journal of Animal Science2004，82，： | 1 |
| 5 | Effect of low and high forage diet on enteric and manure pack greenhouse gas emissions from a feedlot显示文摘 | BOADI D A WITTENDERG K M SCOTT S L | 2004 | Canadian Journal of Animal Science2004，84，： | 1 |
| 6 | Blood urea clearance with microencapsulated urease显示文摘 | Lee K B Boadi D K Neufeld R J | 1995 | J Theor Biol1995，175，： | 1 |
| 7 | Gelatin: a valuable protein for food and pharmaceutical industries: rewiew显示文摘 | Kodjo Boady Djagny Wang Zhang Xu Shi-ying | 2001 | Crit RevFood Sci Nutr2001，41，6： | 1 |
| 8 | Enteric methane emis-sions from backgrounded cattle consuming al forage diets显示文摘 | Ominski K H Boadi D A Wittenberg K M | | 0，，03： | 1 |
| 9 | Micro encapsulation of DNA within alginate micro spheres and crosslinked chitosan membranes for in vivo application显示文摘 | Alexakis T Boadi DK Quong D | | 0，，01： | 1 |
| 10 | Mitigation strategies to reduce enteric methane emissions from dairy cows:Update review显示文摘 | Boadi D Benchaar C Chiquette J | 2004 | Canadian Journal of Animal Science2004，84，3： | 1 |
| 11 | In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells显示文摘 | BOADI W Y LYERE P A ADUNYAH S E | 2005 | Journal of Applied Toxicology2005，25，1： | 1 |
| 12 | Designing of suitable construction of high-frequency induction heating coil by using finite-element method显示文摘 | Alexander Boadi Yuji Tsuchida Takashi Todaka | | 0，，10： | 1 |
| 13 | Detection and species iden- tification of microspofidial infections using SYBR Green real-time PCR 显示文摘 | POLLEY S D BOADI S WATSON J | 2011 | J Med Microbial2011，60，4： | 1 |
| 14 | Gelatin: A Valuable Protein for Food and Pharmaceutical Industries : Review 显示文摘 | Kodjo Boady Djagny Zhang Wang Shiying Xu | 2001 | Critical Reviews in Food Science and Nutri- tion2001，，41： | 1 |
| 15 | Microencapsulation of DNA within alginate microspheres and crosslinked chitosan membranes for in vivo application 显示文摘 | Alexakis T Boadi DK Quong D | 1995 | Appl Biochem Biotechnol1995，50，1： | 1 |
| 16 | Microspheres and crosslinked ehitosan membranes for in vivo application显示文摘 | Alexakis T Boadi DK Quong D | 1995 | Applied Biochemistry and Biotechnology1995，50，： | 1 |
| 17 | Effects of low doses of quercetin and genistein on oxidation and carbonylation in hemoglobin and myoglobin显示文摘 | Boadi WY Johnson D | 2014 | J Diet Suppl2014，11，3： | 1 |
| 18 | Micro-encapsulation of DNA within alginate microspheresand crosslinked chitosan membranes for in vivo appli-cation 显示文摘 | ALEXAKIS T BOADI D K QUONG D | 1995 | Applied Biochemistry and Biotechnology1995，50，1： | 1 |
| 19 | Brazing of pressureless-sintered SiCusing Ag-Cu-Ti alloy 显示文摘 | BOADI J K YANO T ISEKI T | 1987 | J Mater Sci1987，22，24： | 1 |
| 20 | Encapsulation of tannase for the hydrolysis of tea tannins 显示文摘 | Boadi D K | 2001 | Enzyme and Microbial Technology2001，28，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员