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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Effect of drying rate on dehydration sensitivity of excised wheat seedling shoots as a related sucrose metabolism and antioxidant enzyme activities 显示文摘 | NIED ZW IED ZIS BO GA TEK-LESZYN SKA R COM EED | 2004 | Plant Science2004，167，： | 1 |
| 3 | Friction and wear behavior of ZrO2-Al2O3 composite coatings deposited by air plasma spraying, Correlation with physical and mechanical properties 显示文摘 | Liang Bo Zhang Ga Liao Hanlin | 2009 | Surface & Coatings Technology2009，203，： | 1 |
| 4 | Immortalization of human marrow stromal cells by retroviral transduction with a temperature sensitive oncogene: identification of bipotential precursor cells capable of directed differentiation to either an osteoblast or an adipocyte phenotype显示文摘 | Houghton A Oyajobi BO Foster GA | 1998 | Bone1998，22，1： | 1 |
| 5 | Quick sex determination of mouse fetuses 显示文摘 | Lambert JF Benoit BO Colvin GA | 2000 | J Neurosci Methods2000，95，2： | 1 |
| 6 | A pregnant Iady with intermittent vaginal bleeding显示文摘 | Koo BO Sala E Hackett GA | 2007 | European Radiology2007，19，11： | 1 |
| 7 | Ovarian superstimulatory response relative to follicular wave emergence in heifers显示文摘 | Nasser LF Adams GP Bo GA | 1993 | Therio1993，40，71： | 1 |
| 8 | The Newcastle-Ottawa Scale(NOS) for assessing the quality if nonrandomized studies in meta analyses显示文摘 | Wells GA Shea BO Connell D | 2013 | PLoS Negl Trop Dis2013，7，5： | 1 |
| 9 | Friction and wear behavior of ZrO2-Al2O3 composite coatings deposited by air plasma spraying:Correlation with physical and mechanical properties显示文摘 | Liang Bo Zhang Ga Liao Hanlin | 2009 | Surface &Coatings Technology2009，203，： | 1 |
| 10 | Quick determination of mouse fetuses显示文摘 | Lambert JF Benoit BO Colvin GA | 2000 | J Neurosci Methods2000，95，2： | 1 |
| 11 | Quick sex determination of mouse fetuses显示文摘 | Benoit BO Colvin GA | 2000 | J Neurocsi Method2000，95，2： | 1 |
| 12 | Technologies for fixedtime artificial insemination and their influence on reproductive performance of Bos indicus cattle显示文摘 | Bo GA Cutaia L Peres L C | 2007 | Soc Reprod Fertil Suppl2007，64，： | 1 |
| 13 | Toxicity study of Hibiscus cannabinus 显示文摘 | Agbor GA Oben JE Brahim BO | 2004 | J Cameroon Acad Sci2004，4，1： | 1 |
| 14 | Production of ajmalicine and ajmaline in hairy root cultures of Rauvolfia Micrantha Hook,a rare and endemic medicinal plant显示文摘 | Sudha CG Reddy BO Ravishankar GA | 2003 | Biotechnol Lett2003，25，： | 1 |
| 15 | Effect of drying rate on dehydration sensitivity of excised wheat seedling shoots as a related sucrose metabolism and antioxidant enzyme activities 显示文摘 | NIED ZW IED ZIS BO GA TEK-LESZYN SKA R COM EED | 2004 | Plant Science2004，167，： | 1 |
| 16 | Exogenous control of follicular wave emergence in cattle显示文摘 | Bo GA Adams GP Pierson RA | 1995 | Theriogenology1995，43，： | 1 |
| 17 | Alternative approaches to setting up donor cows for superstimulation显示文摘 | Bo GA Guerrero D C Adams GP | 2008 | Theriogenology2008，69，： | 1 |
| 18 | Enhanced oxygen reduction kinetics by a porous heterostructured cathode for intermediate temperature solid oxide fuel cells显示文摘A novel porous heterostructured Nd_(0.8)Sr_(1.2)CoO_(4)±/Nd_(0.5)Sr_(0.5)CoO_(3-δ)(NSC_(214/113))cathode for intermediate tem-perature solid oxide fuel cells(IT-SOFCs)is developed to significantly enhance oxygen reduction reaction(ORR)kinetics.Compared to single-phase materials,the fabricated porous heterostructured NSC 214/113 shows optimized electrochemical properties,including a better conductivity,20 times faster surface oxygen exchange kinetics,and a comparatively lower area-specific resistance(0.065Ωcm^(2) at 800℃).The single cell with Ni-YSZ|YSZ-GDC|NSC_(214/113) configuration exhibits a high peak power density of 1.10 W cm^(−2) at 800℃,superior to other cells reported in literature with similar heterostructured cathodes.Moreover,the underlying mechanism of the ORR performance enhancement is further investigated,revealing that the formation of heterojunction can lead to a narrowed energy bandgap and a decrease of Co oxidation state,which further induce better conductivity,more available electrons and oxygen vacancies to enhance the ORR process.Taken together,our research also provides new insights into potential application of artificial intelligence(AI)method involved in materials in-telligent identification,cell state estimation,system diagnostic and optimization.The revolutionary force of AI,especially in the field of new electrode material development is now advancing in its full swing.More and greater breakthroughs are still expected. | Yun Zheng Chenhuan Zhao Tong Wu Yifeng Li Wenqiang Zhang Jianxin Zhu Ga Geng Jing Chen Jianchen Wang Bo Yu Jiujun Zhang | 2020 | Energy and AI2020，2，2： | 0 |
| 19 | Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets显示文摘Deconvolution of potential drug targets of the central nervous system(CNS)is particularly challenging because of the complicated structure and function of the brain.Here,a spatiotemporally resolved metabolomics and isotope tracing strategy was proposed and demonstrated to be powerful for deconvoluting and localizing potential targets of CNS drugs by using ambient mass spectrometry imaging.This strategy can map various substances including exogenous drugs,isotopically labeled metabolites,and various types of endogenous metabolites in the brain tissue sections to illustrate their microregional distribution pattern in the brain and locate drug action-related metabolic nodes and pathways.The strategy revealed that the sedative-hypnotic drug candidate YZG-331 was prominently distributed in the pineal gland and entered the thalamus and hypothalamus in relatively small amounts,and can increase glutamate decarboxylase activity to elevateγ-aminobutyric acid(GABA)levels in the hypothalamus,agonize organic cation transporter 3 to release extracellular histamine into peripheral circulation.These findings emphasize the promising capability of spatiotemporally resolved metabolomics and isotope tracing to help elucidate the multiple targets and the mechanisms of action of CNS drugs. | Bo Jin Xuechao Pang Qingce Zang Man Ga Jing Xu Zhigang Luo Ruiping Zhang Jiangong Shi Jiuming He Zeper Abliz | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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