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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Serum resistin (FIZZ3) protein is increased in obese humans显示文摘 | Mikzko DY Bovenkerk JE Beth E J | 2003 | Clin En- docrinol Metab2003，88，11： | 1 |
| 3 | TMS1,a novel pro-apoptotic caspase recruitment domain protein,is a target ofmethylation-induced gene silencing in human breast cancers显示文摘 | Kerry E C Beth/M Claire E B | 2000 | Cancer Res2000，60，22： | 1 |
| 4 | Evaluation of a Train - the - Trainer Program to enhance hospice and palliative care in nursing homes显示文摘 | Mary E Beth MK Nathan RH | 2006 | Journal of Hospice and Palliative Nursing2006，8，1： | 1 |
| 5 | The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF显示文摘 | Beth A Luellen A Matthew E | 2006 | Neuropharmacology2006，50，3： | 1 |
| 6 | From scraps to reams:a survey of printing services in academic libraries显示文摘 | Beth A Sara E M | 2002 | College & Research Libraries2002，63，4： | 1 |
| 7 | Beta-cell function and glucose and lipid oxidation in Grave's disease显示文摘 | Beth K Damsbo P Eldrup E | 1996 | Clin Endocrinol1996，44，1： | 1 |
| 8 | Manage-ment factors associated with farrowing rate in commercial sowherds in Ontario显示文摘 | Beth Young Catherine E Dewey Robert M Friendship | 2010 | Can Yet J2010，，51： | 1 |
| 9 | Equation of state in the gravitational collapse of stars显示文摘 | Bethe H A Brown G E Applegate J | 1979 | Nucl Phys A1979，324，： | 1 |
| 10 | Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer显示文摘 | Maria A Kouvaraki Suzanne E Shapiro Bruno D Fornage Beth S Edeiken-Monro Steven I Sherman Rena Vassilopoulou-Sellin Jeffrey E Lee Douglas B Evans | 2003 | Surgery2003，，6： | 1 |
| 11 | The effect of food on the oral bioavailability and the pharacodynamic actions of the insulinotropic agent nateglinide in healthy subjects显示文摘 | Beth E Dunning James F Mcleod | 1999 | J Clin Pharmacol1999，39，： | 1 |
| 12 | Risk,Return and Equilibrium:Empirical Tests显示文摘 | Fama E and Mac Beth J | 1973 | Journal of Political Economy1973，，81： | 1 |
| 13 | Prevention of Hepatitis A Through Active or Passive Immunization 显示文摘 | Anthony E Annemarie W Beth P | 2006 | MMWR2006，55，07： | 1 |
| 14 | Reverse genetic characterization of cytosolic aeetyl - CoA generation by ATP- Citrate Lyase in Arabidopsis显示文摘 | Beth L F Basil J N Wurtelea E S | 2005 | The Plant Cell2005，17，： | 1 |
| 15 | Inclusion and Diversity in Work Groups: A Review and Model for Future Research显示文摘 | Shore L M Amy E R Beth G Ch | 2011 | Journal of Management2011，37，1： | 1 |
| 16 | Radiologic concepts of lymphoma of bone显示文摘 | Beth EM Jack E Edumund K | 1990 | Radiol Clin North Am1990，28，4： | 1 |
| 17 | Percutaneous removal of benign breast masses using a vacuum-assisted hand-held device with ultrasound guidance显示文摘 | Richard E Fine Beth A Boyd Pat W Whitworth Julian A Kim Jay K Harness William E Burak | 2002 | The American Journal of Surgery2002，，4： | 1 |
| 18 | Ginkgo biloba for preventing cognitive decline in older adults a randomized trial 显示文摘 | Beth E Ellen S Michelle C | 2009 | JAMA2009，302，24： | 1 |
| 19 | The Effect of Message Framing on Breast Self-Examination Attitudes,Intentions,and Behavior显示文摘 | Meyerowitz Beth E Shelly Chaiken | | 0，，3： | 1 |
| 20 | Equation of State in the Gravitational Collapse of Stars显示文摘 | BETHE H A BROWN G E APPLEGATE J | 1979 | Nuclear Physics A1979，324，7： | 1 |
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