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| 1 | Hepatocellular carcinoma:Surgical perspectives beyond the barcelona clinic liver cancer recommendations显示文摘The barcelona clinic liver cancer(BCLC)staging system has been approved as guidance for hepatocellular carcinoma(HCC)treatment guidelines by the main Western clinical liver associations.According to the BCLC classification,only patients with a small single HCC nodule without signs of portal hypertension or hyperbilirubinemia should undergo liver resection.In contrast,patients with intermediate-advanced HCC should be scheduled for palliative therapies,even if the lesion is resectable.Recent studies report good short-term and long-term outcomes in patients with intermediate-advanced HCC treated by liver resection.Therefore,this classification has been criticised because it excludes many patients who could benefit from curative resection.The aim of this review was to evaluate the role of surgery beyond the BCLC recommendations.Safe liver resection can be performed in patients with portal hypertension and well-compensated liver function with a 5-year survival rate of 50%.Surgery also offers good long-term result in selected patients with multiple or large HCCs with a reported 5-year survival rate of over 50%and 40%,respectively.Although macrovascular invasion is associated with a poor prognosis,liver resection provides better long-term results than palliative therapies or best supportive care.Recently,researchers have identified several genes whose altered expression influences the prognosis of patients with HCC.These genes may be useful for classifying the biological behaviour of different tumours.A revision of the BCLC classification should be introduced to provide the best treatment strategy and to ensure the best prognosis in patients with HCC. | Alfredo Guglielmi rea Ruzzenente Simone Conci Alessro Valdegamberi Marco Vitali Francesca Bertuzzo Michela De Angelis Guido Mantovani Calogero Iacono | 2014 | World Journal of Gastroenterology2014，20，24： | 16 |
| 2 | Liver transplantation for hepatocellular carcinoma:Role of inflammatory and immunological state on recurrence and prognosis显示文摘Criteria for liver transplantation(LT)for hepatocellular carcinoma(HCC)and post-LT indicators of prognosis are historically based on the measurement of the tumor mass.Recently,high throughput technologies have increased the prediction of recurrence,but these tools are not yet routinely available.The interaction between HCC and the immune system has revealed an imbalance of lymphocyte phenotypes in the peritumoral tissue,and the increase of regulatory T cells with respect to cytotoxic lymphocytes has been linked to a higher rate of post-LT HCC recurrence.Moreover,some inflammatory markers have shown good reliability in predicting cancer reappearance after surgery,as a result of either a systemic inflammatory response or a decreased capacity of the organism to control the tumor growth.Among these markers,the neutrophil-tolymphocyte ratio appears to be the most promising and easily available serum parameter able to predict HCC recurrence after LT and following other types of treatment,although the exact mechanisms determining its elevation have not been clarified.Post-LT immunosuppression may impact on cancer control,and the exposure to high levels of calcineurin inhibitors or other immunusuppressants has recently emerged as a negative prognostic factor for HCC recurrence and patient survival.Despite the absence of prospective randomized trials,inhibitors of the mammalian target of rapamycin have been shown to be associated with lower rates of tumor recurrence compared to other immunosuppressors,suggesting their use especially in patients with HCC exceeding the conventional indication criteria for LT. | Matteo Cescon Valentina Rosa Bertuzzo Giorgio Ercolani Matteo Ravaioli Federica Odaldi Antonio Daniele Pinna | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 3 | Peritoneal seeding from appendiceal carcinoma:A case report and review of the literature显示文摘Non-carcinoid appendiceal malignancies are rare entities,representing less than 0.5% of all gastrointestinal malignancies.Because of their rarity and particular biological behavior,a substantial number of patients affected by these neoplasms do not receive appropriate surgical resection.In this report,we describe a rare case of primary signetring cell carcinoma of the appendix with peritoneal seeding which occurred in a 40-year old man admitted at the Emergency Surgery Department with the clinical suspicion of acute appendicitis.After a surgical debulking and right hemicolectomy,the patient had systemic chemotherapy according to FOLFOX protocol.After completion of the latter,the patient underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.This report offers a brief review of the literature and suggests an algorithm for the management of non-carci-noid appendiceal tumors with peritoneal dissemination. | Valentina R Bertuzzo Federico Coccolini Antonio D Pinna | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 6 |
| 4 | Epidemiological and genetic char-acteristics associated with the severity of acute viral bronchiolitis by res-piratory syncytial virus显示文摘 | Alvarez AE Marson FA Bertuzzo CS | 2013 | J Pediatr(Rio J)2013，89，： | 1 |
| 5 | On spatially explicit models of cholera epidemics 显示文摘 | Bertuzzo E Casagrandi R Gatto M | 2010 | Journal of the Royal Society Interface2010，7，43： | 1 |
| 6 | Survival Benefit After Liver Transplantation: A Single European Center Experience显示文摘 | Matteo Ravaioli Gian Luca Grazi Alessandro Dazzi Valentina Bertuzzo Giorgio Ercolani Matteo Cescon Alessandro Cucchetti Michele Masetti Giovanni Ramacciato Antonio Daniele Pinna | 2009 | Transplantation2009，，6： | 1 |
| 7 | Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus显示文摘 | Alvarez AE Marson FA Bertuzzo CS | 2013 | J Pediatr (Rio J)2013，89，6： | 1 |
| 8 | Analysis of Factors Affecting Recurrence of Hepatocellular Carcinoma After Liver Transplantation With a Special Focus on Inflammation Markers显示文摘 | Valentina Rosa Bertuzzo Matteo Cescon Matteo Ravaioli Gian Luca Grazi Giorgio Ercolani Massimo Del Gaudio Alessandro Cucchetti Antonietta D?Errico-Grigioni Rita Golfieri Antonio Daniele Pinna | 2011 | Transplantation2011，，11： | 1 |
| 9 | Long-term antiviral treatment for recurrent hepatitis C after liver transplantation显示文摘 | Valentina Rosa Bertuzzo Matteo Cescon Maria Cristina Morelli Paolo Di Gioia Mariarosa Tamè Stefania Lorenzini Pietro Andreone Giorgio Ercolani Massimo Del Gaudio Matteo Ravaioli Alessandro Cucchetti Alessandro Dazzi Antonietta D’Errico-Grigioni Antonio Da | 2012 | Digestive and Liver Disease2012，，10： | 1 |
| 10 | Methylenetetrahydrofolate reductase gene polymorphisms and their association with trisomy 21 显示文摘 | Acacio GL Barini R Bertuzzo CS | 2005 | Prenat Diagn2005，25，13： | 1 |
| 11 | Preoperative autologous blood donation by 1073 elderly patients undergoing elective surgery: safe and effective practice显示文摘 | Gandini G Franchini M Bertuzzo D | 1999 | Transfusion1999，39，2： | 1 |
| 12 | Modeling cholera epidemics: the role of waterways, human mobility and sanitation显示文摘 | Mari L Bertuzzo E Righetto L | 2012 | J R Soc Interface2012，9，37： | 1 |
| 13 | Analysis of Factors Affecting Recurrence of Hepatocellular Carcinoma After Liver Transplantation With a Special Focus on Inflammation Markers显示文摘 | Valentina Rosa Bertuzzo Matteo Cescon Matteo Ravaioli Gian Luca Grazi Giorgio Ercolani Massimo Del Gaudio Alessandro Cucchetti Antonietta D?Errico-Grigioni Rita Golfieri Antonio Daniele Pinna | 2011 | Transplantation2011，，11： | 1 |
| 14 | Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers显示文摘 | Bertuzzo VR Cescon M Ravaioli M | 2011 | Transplantation2011，91，11： | 1 |
| 15 | Nonpoint source transport models from empiricism to coherent theoretical frameworks显示文摘 | Andrea Rinaldo Enrico Bertuzzo Gianluca Botter | 2004 | Ecological Modelling2004，，1： | 1 |
| 16 | Analysis of Factors Affecting Recurrence of Hepatocellular Carcinoma After Liver Transplantation With a Special Focus on Inflammation Markers显示文摘 | Valentina Rosa Bertuzzo Matteo Cescon Matteo Ravaioli Gian Luca Grazi Giorgio Ercolani Massimo Del Gaudio Alessandro Cucchetti Antonietta D?Errico-Grigioni Rita Golfieri Antonio Daniele Pinna | 2011 | Transplantation2011，，11： | 1 |
| 17 | Measured versus Estimated Total Liver Volume to Preoperatively Assess the Adequacy of the Future Liver Remnant: Which Method Should We Use?显示文摘 | Dario Ribero Marco Amisano Francesca Bertuzzo Serena Langella Roberto Lo Tesoriere Alessandro Ferrero Daniele Regge Lorenzo Capussotti | 2013 | Annals of Surgery2013，，5： | 1 |
| 18 | APC germline mutations in families with familial adenomatous polyposis显示文摘 | Lillian Rossanese Fernando Marson José Ribeiro Claudio Coy Carmen Bertuzzo | 2013 | Oncology Reports2013，，5： | 1 |
| 19 | River networks and ecological corridors: Reactive transport on fractals, migration fronts, hydrochory显示文摘 | Bertuzzo E Maritan A Gatto M | 2007 | Water Resources Research2007，43，4： | 1 |
| 20 | Methylenetetra hydrofolate rednctase gene polymorphisms arid their agsociation with trisomy 21 显示文摘 | Acacio GL Batini R Bertuzzo CS | 2005 | Prenat Diagn2005，25，13： | 1 |
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