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10篇 您的检索式：作者名="Benoit Viollet"

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		题名	作者	年代	出处	被引量
	1	Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival显示文摘Autophagy is a cellular self-eating process essential for stress response and maintainingtissue homeostasis by lysosomal degradation of unwanted or damaged proteins and organelles.Here, we show that cells with defective mitochondria induce autophagy to promotecell survival through activating the AMPK pathway. Loss of mitochondrial complex III proteincytochrome b activates the AMPK signaling and induced autophagy. Inhibiting mitochondria energeticsby mitochondria-targeted agents activates the AMPK signaling and induced autophagy.Genetic inhibition of AMPK inhibits autophagy induction in cells with defective mitochondria,while genetic inhibition of autophagy has no effect on AMPK activation. Mitochondria dysfunctionhas no effect of DNA repair of UV-induced DNA damage. However, mitochondria dysfunctionsensitizes cells to apoptosis induced by UV radiation. Genetic inhibition of autophagy orAMPK sensitized cells to apoptosis in cells with defective mitochondria. Our results demonstratethat AMPK and autophagy senses mitochondria dysfunction and serves as a mechanismfor survival. Our findings may provide new insights into the interplay between mitochondriafunction and autophagy process in maintaining tissue homeostasis, and suggest that this interactionmay play important roles in diseases such as cancer and neurodegeneration.	Baozhong Zhao Lei Qiang Joy Joseph Balaraman Kalyanaraman Benoit Viollet Yu-Ying He	2016	Genes & Diseases2016，3，1：	6
	2	Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state显示文摘	Foretz Marc Hébrard Sophie Leclerc Jocelyne Zarrinpashneh Elham Soty Maud Mithieux Gilles Sakamoto Kei Andreelli Fabrizio Viollet Benoit	2010	Journal of Clinical Investigation2010，，7：	2
	3	Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.显示文摘	Heeseog Kang Benoit Viollet Dianqing Wu	2013	Journal of Biological Chemistry2013，，32：	1
	4	Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes显示文摘	Xie Zhonglin Zhang Junhua Wu Jiliang Viollet Benoit Zou Ming-Hui	2008	Diabetes2008，，12：	1
	5	AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo: Role of 26S Proteasomes显示文摘	Shuangxi Wang Miao Zhang Bin Liang Jian Xu Zhonglin Xie Chao Liu Benoit Viollet Daoguang Yan Ming-Hui Zou	2010	Circulation Research2010，，6：	1
	6	AMPK α1: A glucose sensor that controls CD 8 T ‐cell memory显示文摘	Julia Rolf Marouan Zarrouk David K. Finlay Marc Foretz Benoit Viollet Doreen A. Cantrell	2013	Eur. J. Immunol2013，，4：	1
	7	AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration显示文摘	Rémi Mounier Marine Théret Ludovic Arnold Sylvain Cuvellier Laurent Bultot Olga G?ransson Nieves Sanz Arnaud Ferry Kei Sakamoto Marc Foretz Benoit Viollet Bénédicte Chazaud	2013	Cell Metabolism2013，，：	1
	8	Targeting the AMPK pathway for the treatment of Type 2 diabetes显示文摘	Benoit Viollet Louise Lantier Jocelyne Devin-Leclerc		0，，：	1
	9	Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism显示文摘	David Carling Benoit Viollet	2015	Cell Metabolism2015，，6：	1
	10	Expanding roles for AMPK in skeletal muscle plasticity显示文摘	Rémi Mounier Marine Théret Louise Lantier Marc Foretz Benoit Viollet	2015	Trends in Endocrinology & Metabolism2015，，6：	1

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